Role of preoperative malnutrition and symptom severity in anorexia-cachexia-related quality of life in patients with operable pancreatic cancer

Chou, Yun; Liou, Yen-Lyin; Lai, Sheng-Ru; Tien, Yu-Wen; Kuo, Hsuan-Ju; Yang, Huei-Jiun; Shun, Shiow Ching

doi:10.1016/j.ejon.2023.102352

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…As a potential reason, a study by Dalamaga et al suggested that low muscle mass can contribute to tumor growth through increased inflammation [ 74 ]. The correlation of nutrition and QoL found in our study is also supported by studies for patients with lung cancer, colorectal cancer and pancreatic cancer [ 13 , 14 , 75 , 76 ]. A study by Gharagozlian et al on long-term survivors of gastrectomies for cancer found patients with malnutrition to have lower QoL, and a study by Maia et al produced similar results [ 77 , 78 ].…”

Section: Discussionsupporting

confidence: 90%

Quality of Life, Sarcopenia and Nutritional Status in Patients with Esophagogastric Tumors before and after Neoadjuvant Therapy

Schooren,

Oberhoff,

Koch

et al. 2024

Cancers

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(1) Background: Health-related quality of life (HRQoL) gains importance as novel treatment options for individuals with esophagogastric tumors to improve long-term survival. Impaired HRQoL has been shown to be a predictor of overall survival. Sarcopenia is a known prognostic factor for postoperative complications. As the regular control of sarcopenia through CT scans might not always be possible and HRQoL and nutritional scores are easier to obtain, this study aimed to assess the relationship between nutritional scores, HRQoL and skeletal muscle mass in patients undergoing chemotherapy for cancers of the upper gastrointestinal tract. (2) Methods: Eighty patients presenting with tumors of the upper GI tract were included and asked to fill out the standardized HRQoL questionnaire, EORTC’s QLQ-C30. Nutritional status was assessed using the MNA, MUST and NRS 2002 scores. Sarcopenia was determined semi-automatically based on the skeletal muscle index at the L3 vertebrae level in staging CT scans. (3) Results: In chemo-naïve patients, HRQoL summary scores correlated significantly with nutritional scores and SMI. SMI and HRQoL prior to neoadjuvant therapy correlated significantly with SMI after treatment. (4) Conclusions: HRQoL is a helpful tool for assessing patients’ overall constitution. The correlation of HRQoL summary scores and SMI might allow for a rough assessment of skeletal muscle status through HRQoL assessment in chemo-naïve patients.

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