Role of preoperative breast dual‐energy contrast‐enhanced digital mammography in ductal carcinoma in situ

Vignoli, Chiara; Bicchierai, Giulia; Benedetto, Diego De; Boeri, Cecilia; Vanzi, E.; Miele, Vittorio; Cirone, Donatello; Nori, Jacopo

doi:10.1111/tbj.13408

Cited by 10 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In breast tissues, microcalcifications play a crucial role in early cancer diagnosis [2]. Indeed, approximately 50% of non-palpable breast cancers are detected by mammography exclusively through microcalcification patterns [3], revealing up to 90% of ductal carcinoma in situ [4]. They can be classified according to their appearance on a mammogram based on the Breast Imaging Reporting and Data system [5], or by their physical and chemical properties [6].…”

Section: Introductionmentioning

confidence: 99%

Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition

Scimeca

Bonfiglio

Menichini

et al. 2019

IJMS

View full text Add to dashboard Cite

Background: This study aims to investigate: (a) the putative association between the presence of microcalcifications and the expression of both epithelial-to-mesenchymal transition and bone biomarkers, (b) the role of microcalcifications in the breast osteoblast-like cells (BOLCs) formation, and (c) the association between microcalcification composition and breast cancer progression. Methods: We collected 174 biopsies on which we performed immunohistochemical and ultrastructural analysis. In vitro experiments were performed to demonstrate the relationship among microcalcification, BOLCs development, and breast cancer occurrence. Ex vivo investigations demonstrated the significant increase of breast osteoblast-like cells in breast lesions with microcalcifications with respect to those without microcalcifications. Results: In vitro data displayed that in the presence of calcium oxalate and activated monocytes, breast cancer cells undergo epithelial to mesenchymal transition. Also, in this condition, cells acquired an osteoblast phenotype, thus producing hydroxyapatite. To further confirm in vitro data, we studied 15 benign lesions with microcalcification from patients that developed a malignant condition in the same breast quadrant. Immunohistochemical analysis showed macrophages’ polarization in benign lesions with calcium oxalate. Conclusions: Altogether, our data shed new light about the role of microcalcifications in breast cancer occurrence and progression.

show abstract

Section: Introductionmentioning

confidence: 99%

Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition

Scimeca

Bonfiglio

Menichini

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…Like CEDM, 3,10 DCIS of all grades, both calcified and non‐calcified, typically manifests as masses and non mass enhancement, 3,5 usually with peak contrast enhancement later than IDC 3 . Discrete enhancing foci or masses of variable distribution have also been described (usually lower histological grade), most commonly with plateau or washout enhancement kinetics 12 …”

Section: Literature Reviewmentioning

confidence: 99%

“…2). 10 The use of CEDM is expanding; though, further studies are required to understand its utility in the detection of this specific entity.…”

Section: Literature Reviewmentioning

confidence: 99%

The imaging appearances of non‐calcified ductal carcinoma in situ: A pictorial essay

Falkner

Porter

2023

J Med Imag Rad Onc

View full text Add to dashboard Cite

SummaryNon‐calcified ductal carcinoma in situ (NCDCIS) presents as a heterogeneous entity on various imaging modalities, most frequently presenting symptomatically as a palpable lump. The combination of multiple modalities and knowledge of its potential radiological appearances are important in minimising misdiagnosis. Compared to conventional 2D mammography, both sonography and digital breast tomosynthesis show higher diagnostic accuracy in the detection of NCDCIS. Newer modalities of contrast‐enhanced digital mammography and MRI have limited data at present, but early results indicate greater sensitivity for the detection of lesions that may be occult on ultrasound or mammography. Here, we present an illustrative study highlighting the varied appearances of NCDCIS on several imaging modalities including a brief review of the literature.

show abstract

“…In particular, contrast-enhanced mammography may prove helpful to better define extent of disease by identifying both calcified and noncalcified DCIS and also to identify occult invasive cancer by detecting enhancing invasive cancer in the setting of DCIS calcifications. Although only a small number of retrospective studies on contrastenhanced mammography have included many DCIS cases to date (range, 19-37 DCIS cases), they demonstrate the promise of contrast-enhanced mammography in the detection of pure DCIS and mixed DCIS and/or invasive cancer (75%-100% of DCIS lesions showed enhancement) (Fig 4) (74,75).…”

Section: Contrast-enhanced Mammographymentioning

confidence: 99%

Ductal Carcinoma in Situ: State-of-the-Art Review

et al. 2022

View full text Add to dashboard Cite

Role of preoperative breast dual‐energy contrast‐enhanced digital mammography in ductal carcinoma in situ

Cited by 10 publications

References 8 publications

Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition

Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition

The imaging appearances of non‐calcified ductal carcinoma in situ: A pictorial essay

Ductal Carcinoma in Situ: State-of-the-Art Review

Contact Info

Product

Resources

About