Role of Postoperative C‐Reactive Protein Levels in Predicting Prognosis After Surgical Treatment of Esophageal Cancer

Ibuki, Yuta; Hamai, Yoichi; Hihara, Jun; Emi, Manabu; Taomoto, Junya; Furukawa, Takaoki; Yamakita, Ichiko; Kurokáwa, Tomonori; Okada, Minoru

doi:10.1007/s00268-017-3900-3

Cited by 31 publications

(25 citation statements)

References 48 publications

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“…Therefore, the present results suggest that poorer survival is at least in part dependent on the magnitude of the postoperative systemic inflammatory response, even in patients who have received perioperative steroid therapy and ERAS care. The clinical impact of the postoperative serum CRP level in patients with esophageal cancer has been reported previously (15,16). In the present study, the hazard ratio (HR) for RFS was 2.558 [95% confidence interval (CI)=1.422-4.602] and that for OS was 2.281 (95% CI=1.120-4.646).…”

Section: Discussionsupporting

confidence: 55%

“…Recently, systemic inflammatory responses after surgery have been reported to be associated with survival in patients with cancer (13,14). C-Reactive protein (CRP) is regarded as a biochemical marker of a systemic inflammatory response (15). In addition, a postoperatively elevated CRP level is associated with poor outcomes in various malignancies, including esophageal cancer (15)(16)(17)(18).…”

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confidence: 99%

“…C-Reactive protein (CRP) is regarded as a biochemical marker of a systemic inflammatory response (15). In addition, a postoperatively elevated CRP level is associated with poor outcomes in various malignancies, including esophageal cancer (15)(16)(17)(18).…”

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confidence: 99%

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Postoperative Level of C-Reactive Protein Is a Prognosticator After Esophageal Cancer Surgery With Perioperative Steroid Therapy and Enhanced Recovery After Surgery Care

Kano

Aoyama

Maezawa

et al. 2019

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Background: This study investigated the impact of postoperative C-reactive protein (CRP) level on survival in patients with esophageal cancer who received perioperative steroid therapy and enhanced recovery after surgery (ERAS) care. Patients and Methods: Overall, 115 patients were retrospectively reviewed. The patients were classified into those with a high CRP level (≥4.0 mg/dl) on postoperative day 4 and those with low CRP level (<4.0 mg/dl). The risk factors for overall survival (OS) and recurrence-free survival (RFS) were identified. Results: The OS and RFS rates at 5 years after surgery were significantly low in patients with high CRP level on postoperative day 4. The multivariate analysis demonstrated that high CRP level on postoperative day 4 was a significant independent risk factor for OS and RFS. Conclusion: The present results suggest that the postoperative CRP level can be a prognosticator in patients with esophageal cancer who have received perioperative steroid therapy and ERAS care. Esophageal cancer is the world's eighth most-common cancer and the sixth leading cause of cancer-related death among those with cancer (1). Multimodal therapy, including curative resection and perioperative adjuvant treatment, is 587 This article is freely accessible online.

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Section: Discussionsupporting

confidence: 55%

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confidence: 99%

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Postoperative Level of C-Reactive Protein Is a Prognosticator After Esophageal Cancer Surgery With Perioperative Steroid Therapy and Enhanced Recovery After Surgery Care

Kano

Aoyama

Maezawa

et al. 2019

In Vivo

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“…All patients were histologically diagnosed with squamous cell carcinoma and staged according to the 8 th Edition of the TNM Classification of Malignant Tumors [20]. Treatment strategy was determined at our institutions according to clinical stage and patient condition as described previously [21,22]. Briefly, mucosal cancer was treated with endoscopic resection, submucosal cancer without lymph node metastasis with initial surgery; and respectable advanced cancer with neoadjuvant therapy followed by surgery if overall patient condition was good.…”

Section: Samplesmentioning

confidence: 99%

Circulating microRNA/isomiRs as novel biomarkers of esophageal squamous cell carcinoma

et al. 2020

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Background MicroRNA (miR)s are promising diagnostic biomarkers of cancer. Recent next generation sequencer (NGS) studies have found that isoforms of micro RNA (isomiR) circulate in the bloodstream similarly to mature micro RNA (miR). We hypothesized that combination of circulating miR and isomiRs detected by NGS are potentially powerful cancer biomarker. The present study aimed to investigate their application in esophageal cancer.

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“…The postoperative level of CRP, which has been described as a postoperative risk marker in other tumors (18,27) was not associated with the prognosis in CCA. In contrast, an increased peak number of leukocytes was associated with a poorer OS, showing some degree of contradiction between these two findings.…”

Section: Discussionmentioning

confidence: 78%

The postoperative peak number of leukocytes after hepatectomy is a significant prognostic factor for cholangiocarcinoma

et al. 2019

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Cholangiocarcinoma (CCA) is a lethal disease. A new predictive factor to identify patients suitable for adjuvant chemotherapy is needed. The relationship between the long-term prognosis and the perioperative immune responses in patients with CCA remains unclear. We therefore investigated the clinical impact of perioperative immune responses on the long-term prognosis in patients receiving hepatectomy for CCA. We investigated 81 patients who underwent hepatectomy between February 2000 and October 2012: 57 intra-hepatic CCA (iCCA) patients and 24 extra-hepatic CCA (eCCA) patients. We checked the postoperative level of C-reactive protein and the numbers of leukocytes. A multivariate analysis of the clinicopathological factors identified 2 significant risk factors for the overall survival: The postoperative maximum number of leukocytes (PNL) among patient factors (P=0.0406) and the TNM-stage among tumor factors (P=0.0059). On evaluating the distribution of each kind of leukocyte with a multivariate analysis, both the postoperative maximum number of neutrophils (PNN) and the postoperative maximum number of eosinophils (PNE) were detected as significant factors among leukocytes (PNN/PNE, P= 0.0367/0.0083). In conclusion, the PNL after hepatectomy was significantly associated with the long-term prognosis in patients with CCA. Changes in the numbers of leukocytes after hepatectomy may be a marker on treatment for CCA.

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Role of Postoperative C‐Reactive Protein Levels in Predicting Prognosis After Surgical Treatment of Esophageal Cancer

Abstract: Postoperative CRP levels could predict the prognosis of patients with esophageal cancer. We propose that the clinical course of postoperative CRP level should be carefully monitored as a predictor of survival.

Cited by 31 publications

References 48 publications

Postoperative Level of C-Reactive Protein Is a Prognosticator After Esophageal Cancer Surgery With Perioperative Steroid Therapy and Enhanced Recovery After Surgery Care

Postoperative Level of C-Reactive Protein Is a Prognosticator After Esophageal Cancer Surgery With Perioperative Steroid Therapy and Enhanced Recovery After Surgery Care

Circulating microRNA/isomiRs as novel biomarkers of esophageal squamous cell carcinoma

The postoperative peak number of leukocytes after hepatectomy is a significant prognostic factor for cholangiocarcinoma

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