2013
DOI: 10.1128/mmbr.00052-12
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Role of Pore-Forming Toxins in Bacterial Infectious Diseases

Abstract: SUMMARY Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are required for virulence in a large number of important pathogens, including Streptococcus pneumoniae , group A and B streptococci, Staphylococcus aureus , Escherichia coli , and Mycobacterium tuberculosis . PFTs generally disrupt host cell membranes, but they can have additional effects independent of po… Show more

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Cited by 347 publications
(361 citation statements)
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“…S. pneumoniae and S. aureus can secrete pore-forming toxins during infection that aid in bacterial invasion. PFTs are the largest single class of proteinaceous bacterial toxins (19,20), and many PFTs gain access to the host cell through binding to cholesterol or lipid derivatives in lipid rafts on the cell surface, resulting in subsequent oligomerization and pore formation (21,22). Pneumolysin (PLY), a member of the cholesteroldependent cytolysin family, is a major virulence factor that is expressed by virtually all clinical isolates of S. pneumoniae.…”
mentioning
confidence: 99%
“…S. pneumoniae and S. aureus can secrete pore-forming toxins during infection that aid in bacterial invasion. PFTs are the largest single class of proteinaceous bacterial toxins (19,20), and many PFTs gain access to the host cell through binding to cholesterol or lipid derivatives in lipid rafts on the cell surface, resulting in subsequent oligomerization and pore formation (21,22). Pneumolysin (PLY), a member of the cholesteroldependent cytolysin family, is a major virulence factor that is expressed by virtually all clinical isolates of S. pneumoniae.…”
mentioning
confidence: 99%
“…For the purpose of invasion, several pathogenic bacteria produce PFTs, such as β-barrel-type aerolysins, which can oligomerize and form pores in host-cell membranes (12,13). The aerolysin domain is defined according to its structural similarity to the transmembrane domain of aerolysin toxins.…”
mentioning
confidence: 99%
“…PFTs were used as live vaccines in various disease models, but successful immunization against a PFT does not always prevent disease (46). Other examples such as inhibiting PFTs and using competitive inhibitors were shown to prevent or cure the infection (46).…”
Section: Discussionmentioning
confidence: 99%
“…For the treatment of increasingly antibiotic-resistant bacteria, the development of new, narrower-spectrum or virulence-targeted antimicrobial therapeutics is necessary (45,46). PFTs were used as live vaccines in various disease models, but successful immunization against a PFT does not always prevent disease (46).…”
Section: Discussionmentioning
confidence: 99%