Role of Polyethylene Glycol Integrity in Specific Receptor Targeting of Carbon Nanotubes to Cancer Cells

Zeineldin, Reema; Al-Haik, Marwan; Hudson, Laurie G.

doi:10.1021/nl8033174

Cited by 76 publications

(72 citation statements)

References 37 publications

(94 reference statements)

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“…Simulations showed that PEGylated SWNTs penetrated into the lipid bilayer slower than unPEGylated SWNTs. Also, penetration of the PEGylated SWNT showed a less energy-dependent mechanism, indicating lower adhesion energy, which favorably compared with their previous experiments [178].…”

Section: Pegylated Lipidssupporting

confidence: 66%

Molecular Modeling of PEGylated Peptides, Dendrimers, and Single-Walled Carbon Nanotubes for Biomedical Applications

Lee

2014

Polymers

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Polyethylene glycol (PEG) has been conjugated to many drugs or drug carriers to increase their solubility and circulating lifetime, and reduce toxicity. This has motivated many experimental studies to understand the effect of PEGylation on delivery efficiency. To complement the experimental findings and uncover the mechanism that cannot be captured by experiments, all-atom and coarse-grained molecular dynamics (MD) simulations have been performed. This has become possible, due to recent advances in simulation methodologies and computational power. Simulations of PEGylated peptides show that PEG chains wrap antimicrobial peptides and weaken their binding interactions with lipid bilayers. PEGylation also influences the helical stability and tertiary structure of coiled-coil peptides. PEGylated dendrimers and single-walled carbon nanotubes (SWNTs) were simulated, showing that the PEG size and grafting density significantly modulate the conformation and structure of the PEGylated complex, the interparticle aggregation, and the interaction with lipid bilayers. In particular, simulations predicted the structural transition between the dense core and dense shell of PEGylated dendrimers, the phase behavior of self-assembled complexes of lipids, PEGylated lipids, and SWNTs, which all favorably compared with experiments. Overall, these new findings indicate that simulations can now predict the experimentally observed structure and dynamics, as well as provide atomic-scale insights into the interactions of PEGylated complexes with other molecules.

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Section: Pegylated Lipidssupporting

confidence: 66%

Molecular Modeling of PEGylated Peptides, Dendrimers, and Single-Walled Carbon Nanotubes for Biomedical Applications

Lee

2014

Polymers

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“…Moreover, SWCNTs have been shown to enter mammalian cells Chin et al, 2007;Kam et al, 2004;Kostarelos et al, 2007) and due to their promising properties, SWCNT-based materials have already been investigated as potential delivery vehicles for intracellular transport of nucleic acids Pantarotto et al, 2004), proteins (Kam et al, 2004; and drug molecules Chen et al, 2008;. SWCNTs have been functionalized with antibodies and low-molecular-weight targeting agents, providing high efficiency for nanotube internalization into cells Bottini et al, 2006;Cato et al, 2008, Singh et al, 2005Kang et al, 2008;Shao et al, 2007;Welsher et al, 2008;Zeineldin et al, 2009).These systems also have higher loading capacity and allow for the incorporation of targeting agents and stealth molecules may also be added to evade the immune system. (Mu et al, 2009;Heister et al,2009) Such systems have been loaded with drug molecules such as doxorubicin (DOX) via p-p stacking interactions, methotrexate, Paclitaxel and quercetin.…”

Section: Carbon Nanotubes and Their Impor-tance In Anticancer Drug Dementioning

confidence: 99%

“…Nevertheless, the first generation SWCNTs proved to be unsuitable as drug delivery vectors as they tended to form bundles that disperse poorly in aqueous solutions and were therefore unsuitable for pharmacological use. To overcome this drawback, synthetic polymers such as poly(phenylacetylene) (Zeineldin et al, 2009, Yuan et al, 2006 and natural polymers such as polysaccharides Yuan et al, 2006;Abarrategi et al, 2008;Fu et al, 2007;Hasegawa et al, 2004;Long et al, 2008;Numata et al, 2004;Zhang et al, 2008) have been used to encase SWCNTs via non-covalent interactions, thereby improving their compatibility with water and physiological environments.…”

Section: Carbon Nanotubes and Their Impor-tance In Anticancer Drug Dementioning

confidence: 99%

Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

Kushwaha¹,

Ghoshal²,

Kumar³

et al. 2013

Braz. J. Pharm. Sci.

113

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Carbon nanotubes (CNTs) were discovered in 1991 and shown to have certain unique physicochemical properties, attracting considerable interest in their application in various fields including drug delivery. The unique properties of CNTs such as ease of cellular uptake, high drug loading, thermal ablation, among others, render them useful for cancer therapy. Cancer is one of the most challenging diseases of modern times because its therapy involves distinguishing normal healthy cells from affected cells. Here, CNTs play a major role because phenomena such as EPR, allow CNTs to distinguish normal cells from affected ones, the Holy Grail in cancer therapy. Considerable work has been done on CNTs as drug delivery systems over the last two decades. However, concerns over certain issues such as biocompatibility and toxicity have been raised and warrant extensive research in this field.Uniterms: Carbon nanotubes/properties. Carbon nanotubes/use/drugs delivery. Single-Walled Carbon Nanotube. Multiwalled Carbon Nanotube. Anticancer drugs/delivery. Cancer/therapy. Drugs/delivery.Os nanotubos de carbono foram descobertos em 1991 e suas propriedades físico-químicas únicas demonstradas, despertando interesse em sua aplicação em vários campos, incluindo a entrega liberação de fármacos. As propriedades únicas dos nanotubos de carbono, tais como a facilidade de captação pela célula, carga alta de fármaco, ablação térmica, entre outras, tornaram-nos úteis para terapia de câncer, uma das doenças mais difíceis dos tempos modernos, pois sua terapia envolve a distinção entre as células normais saudáveis e as afetadas pela doença. Os nanotubos de carbono têm um papel importante nessa área porque fenômenos como EPR permitem que estes possam distinguir as células normais das afetadas, que é o Santo Graal na terapia do câncer. Trabalho considerável tem sido feito ao longo das duas últimas década com nanotubos de carbono, como sistemas de liberação de fármacos. No entanto, preocupações sobre algumas questões, como biocompatibilidade e toxicidade, surgiram ao longo do tempo, demandando extensas pesquisa nesse campo. Unitermos: Nanotubos de carbono/propriedades. Nanotubos de carbono/uso/liberação de fármacos. Nanotubo de carbono de parede única. Nanotubo de parede múltipla. Fármacos anticancer/liberação. Cancer/tratamento. Fármacos/liberação.

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“…Single-walled carbon nanotubes (SWNTs) have received considerable research attention due to their many potential applications [1,2].…”

Section: Introductionmentioning

confidence: 99%

Fluorescence properties of aromatic amine adsorbed on metallic and semiconducting single-walled carbon nanotubes

Kubota

Maruyama

Nishikiori

et al. 2011

Journal of Photochemistry and Photobiology A: Chemistry

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Semiconducting single-walled carbon nanotubes (SWNTs) have been enriched by 1-aminopyrene treatment of the mildly oxidized SWNTs due to removal of metallic SWNTs having a higher affinity for 1-aminopyrene.The enrichment was caused by the differences in the adsorption properties of 1-aminopyrene on the metallic and semiconducting SWNTs.The fluorescence properties of 1-aminopyrene adsorbed on the metallic and semiconducting 2 SWNTs have been investigated in order to clarify its adsorption mechanism.1-Aminopyrene was adsorbed on the metallic SWNTs through the interaction of the amino group with the graphene surface and through a hydrogen bonding interaction between the amino group and the carboxyl group on the graphene surface.On the other hand, in the case of semiconducting SWNTs, 1-aminopyrene was adsorbed through a π-π interaction on the graphene surface in addition to the hydrogen bonding interaction with the carboxyl groups.

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Role of Polyethylene Glycol Integrity in Specific Receptor Targeting of Carbon Nanotubes to Cancer Cells

Cited by 76 publications

References 37 publications

Molecular Modeling of PEGylated Peptides, Dendrimers, and Single-Walled Carbon Nanotubes for Biomedical Applications

Molecular Modeling of PEGylated Peptides, Dendrimers, and Single-Walled Carbon Nanotubes for Biomedical Applications

Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

Fluorescence properties of aromatic amine adsorbed on metallic and semiconducting single-walled carbon nanotubes

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