Role of Polycyclic Aromatic Hydrocarbons as EDCs in Metabolic Disorders

Khan, Ajab; Ahsan, Anam; Farooq, Muhammad Asim; Naveed, Muhammad; Li, Hongquan

doi:10.1007/978-3-030-45923-9_19

Cited by 9 publications

(6 citation statements)

References 87 publications

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“…To date, toxicological research has focused largely on PAHs despite the fact that other classes of PACs are also present in the environment; and sometimes at higher levels than their parent compounds ( Provencher et al, 2020 , Wallace et al, 2020 ). There is a growing body of evidence elucidating the biological effects associated with exposure to other classes of PACs, such as heterocyclic PAHs, N- PAHs, halogenated PAHs and alkylated congeners in biota (Reviewed in: ( Brinkmann et al, 2014 , Khan et al, 2021 , Lee et al, 2017 , Zhang et al, 2016 ). In fact, there are reports that degrees of alkylation or substitution can significantly impact total burden in exposed biota ( Lee et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…There is considerable evidence that PACs can function as EDCs and negatively affect reproductive function ( Bolden et al, 2017 , Khan et al, 2021 ; Lee et al, 2017 , Raez-Villanueva et al, 2021 ; Zhang et al, 2016 ). However, reports on the impacts of PACs on the ovary in mammals are limited.…”

Section: Effect Of Polycyclic Aromatic Compounds (Pacs) On Ovarian De...mentioning

confidence: 99%

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The effects of polycyclic aromatic compounds (PACs) on mammalian ovarian function

Perono

Petrik

Thomas

et al. 2022

Current Research in Toxicology

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Section: Discussionmentioning

confidence: 99%

Section: Effect Of Polycyclic Aromatic Compounds (Pacs) On Ovarian De...mentioning

confidence: 99%

The effects of polycyclic aromatic compounds (PACs) on mammalian ovarian function

Perono

Petrik

Thomas

et al. 2022

Current Research in Toxicology

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“…The first attempt to prevent COVID-19 was achieved through education for hand hygiene using alcohol-based [88] or antimicrobialbased hand sanitizers containing endocrine-disrupting chemicals (EDCs), such as bisphenol A, phthalates, and polychlorinated biphenyls (triclosan and triclocarban) [89,90]. The use of EDCs was demonstrated to induce PO [91]. Exposure to EDCs has been causally related to obesity in model organisms and obesity occurrence in humans.…”

Section: Management Of Pediatric Obesity and Strategies For Pediatric...mentioning

confidence: 99%

The Ongoing Impact of COVID-19 on Pediatric Obesity

Iacopetta,

Catalano,

Ceramella

et al. 2024

Pediatric Reports

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In the developed world, pediatric obesity (PO) has been a major health concern since the last century, and this condition may lead to detrimental life-long physical and mental comorbidities. Currently, its prevalence has increased in low- and middle-income countries and in many high-income countries. Thus, the provision of effective and tailored care for children and their families has become vital. The social consequences of the COVID-19 pandemic are known everywhere, and among these, it has been argued that the COVID-19 pandemic has had a major impact on PO. Overall, the growth of PO over the last decade has been enhanced by the pandemic. During the COVID-19 pandemic, children, adolescents and young adults gained weight as the pediatric population dealt with sedentary lifestyles and changes in food habits. In this review, we want to highlight the impact that the COVID-19 pandemic had on PO.

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“…These impacts can include damage to cell membranes, interference with metabolic pathways, disruption of endocrine systems (EDCs), and the induction of oxidative stress [41]. Additionally, hydrocarbon contamination in the environment can lead to ecosystem disruptions, including reduced biodiversity, altered food chains, and habitat degradation, which can further affect human health and environmental stability [42].…”

Section: Hydrocarbon Toxicity and Ecosystem Impactmentioning

confidence: 99%

Advancing Eco-Sustainable Bioremediation for Hydrocarbon Contaminants: Challenges and Solutions

Alaidaroos

2023

Processes

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In an era of rising population density and industrialization, the environment confronts growing challenges. Soil, agricultural land, and water bodies are becoming increasingly polluted by petroleum waste and hydrocarbons. While hydrocarbons are naturally present in crude oil, refining processes compound the complexity and toxicity of hydrocarbons. This is particularly evident in polycyclic aromatic hydrocarbons (PAHs) found in the air and soil, known for their carcinogenic, mutagenic, and teratogenic properties. In response, biodegradation emerges as an eco-friendly, cost-effective solution, especially in petroleum-contaminated settings. Biodiverse microbial communities play a pivotal role in managing hydrocarbon contamination, contingent on location, toxicity, and microbial activity. To optimize biodegradation, understanding its mechanisms is essential. This review delves into varied bioremediation techniques, degradation pathways, and the contributions of microbial activities to efficiently removing hydrocarbon pollutants. Recent research spotlights specific microorganisms like bacteria, microalgae, and fungi adept at hydrocarbon degradation, offering a contemporary perspective on petroleum hydrocarbon pollutant bioremediation. These microorganisms efficiently break down petroleum hydrocarbons, with enzymatic catalysis markedly accelerating pollutant breakdown compared to conventional methods. Given the intricate nature of hydrocarbon contamination, cooperative bacterial consortia are instrumental in effective cleanup, driven by specific genes guiding bacterial metabolism. For cost-effective and efficient removal from compromised environments, it is advisable to adopt an integrated approach that combines biostimulation and bioaugmentation.

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Role of Polycyclic Aromatic Hydrocarbons as EDCs in Metabolic Disorders

Cited by 9 publications

References 87 publications

The effects of polycyclic aromatic compounds (PACs) on mammalian ovarian function

The effects of polycyclic aromatic compounds (PACs) on mammalian ovarian function

The Ongoing Impact of COVID-19 on Pediatric Obesity

Advancing Eco-Sustainable Bioremediation for Hydrocarbon Contaminants: Challenges and Solutions

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