Role of polyanhydrides as localized drug carriers

Jain, Jay Prakash; Modi, Sweta; Domb, Abraham J.; Kumar, Neeraj

doi:10.1016/j.jconrel.2004.12.021

Cited by 171 publications

(110 citation statements)

References 125 publications

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“…To overcome limitations of the systemic therapy and conventional drug delivery systems such as limited drug solubility which leads to poor biodistribution, poor targeting and efficacy, uncontrolled pharmacokinetics, and serious side effects in non-target tissues, local drug delivery using implantable systems has become acceptable as an attractive solution to address these challenges [1,2]. The majority of drugs like antibiotics, anti-cancer and anti-inflammatory drugs are insoluble in water or become unstable during their transport to the targeted sites, hence they require special delivery systems [3,4].…”

Section: Introductionmentioning

confidence: 99%

Controlling Drug Release from Titania Nanotube Arrays Using Polymer Nanocarriers and Biopolymer Coating

Aw¹,

Gulati²,

Lošić³

2011

JBNB

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Titania nanotube arrays (TNT) prepared by self-ordering electrochemical anodization have attracted considerable attention for the development of new devices for local drug delivery applications. Two approaches to extend drug release of water insoluble drugs by integrating TNTs with polymeric micelles and biopolymer coatings are presented in this work. The proposed strategies emphasized on remarkable properties of these materials and their unique combination to design local drug delivery system with advanced performance. The first concept integrates TNTs with drug loaded polymeric micelles (Pluronic F127) as drug nanocarrier, until the second concept includes polymer coating of drug loaded TNT with biodegradable polymer (chitosan). The water insoluble, anti-inflammatory drug, indomethacin was used as a model drug. Both approaches showed a significant improvement of the drug release characteristics, withreduced burst release (from 77% to 39%) and extended overall release from 9 days to more than 28 days. These results suggest the capability of TNT based systems to be applied for local drug delivery deliver over an extended period with predictable kinetics that is particularly important for bone implant therapies.

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Section: Introductionmentioning

confidence: 99%

Controlling Drug Release from Titania Nanotube Arrays Using Polymer Nanocarriers and Biopolymer Coating

Aw¹,

Gulati²,

Lošić³

2011

JBNB

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“…Drug release may be driven either by diffusion of the drug from the polymeric depot, cleavage of the chemical bond between polymeric carrier and the drug, degradation of the polymeric implant, or by combination of these mechanisms [6][7][8] . Besides, controlled chemical degradation of the implant forming polymer (desirable for many in vivo applications) may proceed in whole volume, e.g., hydrazone based hydrogels 9 , from the surface only, e.g., polyanhydrides [10][11][12] , or by combination of both, e.g., polylactides 8,13 .…”

Section: Introductionmentioning

confidence: 99%

“…Polyanhydrides such as poly(sebacic acid) are relatively hydrophobic polymers that degrade in aqueous milieu, by hydrolysis of carboxylic acid anhydride bond into low molecular weight water-soluble dicarboxylic acids which are further metabolized or excreted 10,11,13 . Since, hydrolysis of polyanhydrides strictly begin at the surface so the inner volume of the implant remains dry, until the hydrolytic zone on the surface reaches completely to the core.…”

Section: Introductionmentioning

confidence: 99%

“…Since, hydrolysis of polyanhydrides strictly begin at the surface so the inner volume of the implant remains dry, until the hydrolytic zone on the surface reaches completely to the core. Rate of hydrolysis is inversely proportional to the hydrophobicity of the monomer (increased hydrophobicity decreases degradation rate), and can be controlled upon modification with highly hydrophobic fatty acids 14 , or with use of monomeric composition that increases crystallinity, such as conformationally rigid cyclic diacid comonomers (eg., 1,4-cyclohexanedicarboxylic acid), or aromatic diacid monomers [10][11][12] . This study describes a conceptually new system exploiting the ability of the polyanhydrides to hydrolyze from the surface only, to release the hydrolytically labile drugs, AZA and DAC.…”

Section: Introductionmentioning

confidence: 99%

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Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs

Hrubý¹,

Agrawal²,

Policianova³

et al. 2016

BIOMED PAP

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Background. The archetypal DNA methyltransferase inhibitors, 5-azacytidine (AZA) and 5-aza-2'-deoxycytidine (DAC) are potent antineoplastic agents used in the treatment of mainly, blood malignancies. However, the administration of these drugs is confounded by their hydrolytic lability which decreases plasma circulation time. Here, we describe a new biodegradable, polyanhydride formulation for drug delivery that circumvents this drawback. Methods. Injectable/implantable polymeric microbeads containing dispersed microcrystals of hydrophilic AZA or DAC packed in a dry environment are protected from hydrolysis, until the hydrolytic zone reaches the core. Diclofenac is embedded into the formulation to decrease any local inflammation. The efficacy of the formulations was confirmed by monitoring the induced demethylation, and cytostatic/cytotoxic effects of continuous drug release from the timecourse dissolution of the microbeads, using an in vitro developed cell based reporter system. Results. Poly(sebaccic acid-co-1,4-cyclohexanedicarboxylic acid) containing 30 wt. % drug showed zero-order release (R 2 = 0.984 for linear regression), and release rate of 10.0 %/h within the first 5 h, and subsequent slower release of the remaining drug, thus maintaining the level of drugs in the outer environment considerably longer than the typical plasma half-life of free azanucleosides. At lower concentrations, the differences between powder drug formulations and microbeads were very low or negligible, however, at higher concentrations, we discovered equivalent or increasing effects of the drugs loaded in microbeads. Conclusions. The study provides evidence that microbead formulations of the hydrolytically labile azanucleoside drugs could prevent their chemical decomposition in aqueous solution, and effectively increase plasma circulation time.

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“…As a kind of novel biomaterials for the drug-controlled release system, polyanhydrides are extensively used in the investigation of the controlled release system of anticancer agents [28][29][30], antibiotics [23,30,31], DNA [32], peptides and proteins [33,34], etc. Though there are many advantages, biocompatible polyanhydrides have some limitations.…”

Section: Introductionmentioning

confidence: 99%

Characterization and in vitro degradation of poly(octadecanoic anhydride)

Dong

Zhang

Jiang

et al. 2007

J Mater Sci: Mater Med

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Poly(octadecanoic anhydride) (POA) has been prepared by melt polycondensation of octadecanoic diacid. POA was characterized by Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and wide angle X-ray diffraction (WAXD). The results of in vitro degradation and SEM micrographs show that the erosion process of POA is neither bulk nor perfect surface erosion but rather has elements of both in phosphate buffer at 37°C. The moving erosion front is characteristic of surface erosion whereas the remaining porous shell stems from bulk erosion. While a significant special degradation property of POA is that POA presents a very slow degradation rate in acidic condition (pH 5.98), only 1.64% weight loss for 20 days, and it completely degrades after 18 days in basic buffer (pH 7.4). Comparing with poly(sebacic anhydride) (PSA), POA has the higher crystallization degree, and the slower hydrolytic rate.

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Role of polyanhydrides as localized drug carriers

Cited by 171 publications

References 125 publications

Controlling Drug Release from Titania Nanotube Arrays Using Polymer Nanocarriers and Biopolymer Coating

Controlling Drug Release from Titania Nanotube Arrays Using Polymer Nanocarriers and Biopolymer Coating

Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs

Characterization and in vitro degradation of poly(octadecanoic anhydride)

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