Role of Polyamines in Mediating Antioxidant Defense and Epigenetic Regulation in Plants Exposed to Heavy Metal Toxicity

Paul, Saikat; Banerjee, Aditya; Roychoudhury, Aryadeep

doi:10.1007/978-981-13-2242-6_8

Cited by 30 publications

(25 citation statements)

References 98 publications

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“…Even without chelating Cu, plants can adopt some other strategies to improve the tolerance to Cu stress. Previous studies have shown that polyamines, such as spermidine, putrescine and ethanolamine, as antioxidants, have an important role in the plant response to diverse environmental stresses (Alcázar et al ., 2010; Paul et al ., 2018; Hasanuzzaman et al ., 2019). It has been found that elevated polyamine levels may contribute to enhanced tolerance of lettuce to Cu stress (Zhao et al .…”

Section: Discussionmentioning

confidence: 99%

Analysis of physiological and metabolite response of Celosia argentea to copper stress

Wang

et al. 2021

Plant Biol J

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Copper‐tolerant (Cu) plants with high ornamental value play an important role in the ecological restoration of the copper tail mining area. We first discovered Celosia argentea adaptability in a copper mine area in China; however, its resistance to Cu and the underlying mechanism are not clear. In this study, C. argentea was selected for pot culture experiments. Its heavy metal accumulation and translocation, physiological and metabolic products were analysed under different growth concentrations of Cu (0–2400 mg.kg−1) stress. Our results indicated that roots strongly accumulated Cu2+. Oxidative stress defence mechanisms were activated in leaves under Cu treatment. Higher Cu concentrations triggered higher electrolyte leakage (EL), Malondialdehyde (MDA), superoxide dismutase (SOD) and peroxidase (POD) activity, and consequently a higher capacity to scavenge oxygen radicals and maintain cellular membrane integrity. In the citrate cycle, some amino acids and sugars related to biological pathways were altered in C. argentea exposed to Cu stress. Metabolomics data revealed that C. argentea used elevated sugar content as an antioxidant to regulate reactive oxygen species (ROS). Some organic acids and amino acids were up‐regulated compared with the control, indicating that these may chelate Cu in cells to remove excess Cu2+. The up‐regulation of polyamines and some organic acids may mitigate oxidative stress. These results indicate that C. argentea could be used as a Cu‐tolerant plant in Cu mine restoration. Its Cu tolerance mechanism also provides a basis for future plant improvement or breeding for use in mine restoration.

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Section: Discussionmentioning

confidence: 99%

Analysis of physiological and metabolite response of Celosia argentea to copper stress

Wang

et al. 2021

Plant Biol J

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“…Under metal/metalloid(s) stress the toxic ions stimulate the formation of ROS in plants, hence, create oxidative stress by oxidation of macromolecules like protein, lipids, and DNA [7]. Several reports suggested that excess metal/metalloid(s) can be an obstacle with the metabolism of PAs [6,8]. Groppa et al [6] reported that the metabolisms of PAs are influenced by the application of Cd 2+ or Cu 2+ notably in wheat or sunflower leaf.…”

Section: Introductionmentioning

confidence: 99%

“…The exogenous application of PAs regulates the antioxidative mechanisms in plants under metal/metalloid(s) stress to mitigate the overproduction of ROS [8]. Under Cd stress, the exogenous application of Put and/or sodium nitroprusside (SNP, NO donor) scavenged ROS by improving the activity of enzymes (superoxide dismutase, SOD; catalase, CAT; ascorbate peroxidase, APX; monodehydroascorbate reductase, MDHAR; dehydroascorbate reductase, DHAR; glutathione reductase, GR; glutathione S -transferase, GST; and glutathione peroxidase, GPX) and nonenzymatic antioxidants (ascorbate, AsA and glutathione, GSH) [1].…”

Section: Introductionmentioning

confidence: 99%

Polyamine Action under Metal/Metalloid Stress: Regulation of Biosynthesis, Metabolism, and Molecular Interactions

Hasanuzzaman

Alhaithloul

Parvin

et al. 2019

IJMS

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Polyamines (PAs) are found in all living organisms and serve many vital physiological processes. In plants, PAs are ubiquitous in plant growth, physiology, reproduction, and yield. In the last decades, PAs have been studied widely for exploring their function in conferring abiotic stresses (salt, drought, and metal/metalloid toxicity) tolerance. The role of PAs in enhancing antioxidant defense mechanism and subsequent oxidative stress tolerance in plants is well-evident. However, the enzymatic regulation in PAs biosynthesis and metabolism is still under research and widely variable under various stresses and plant types. Recently, exogenous use of PAs, such as putrescine, spermidine, and spermine, was found to play a vital role in enhancing stress tolerance traits in plants. Polyamines also interact with other molecules like phytohormones, nitric oxides, trace elements, and other signaling molecules to providing coordinating actions towards stress tolerance. Due to the rapid industrialization metal/metalloid(s) contamination in the soil and subsequent uptake and toxicity in plants causes the most significant yield loss in cultivated plants, which also hamper food security. Finding the ways in enhancing tolerance and remediation mechanism is one of the critical tasks for plant biologists. In this review, we will focus the recent update on the roles of PAs in conferring metal/metalloid(s) tolerance in plants.

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“…Since then, growing evidence has been linking PAs with an enhanced tolerance of plants to different kinds of adverse conditions. Either by the use of mutants or by applying exogenous PAs and/or their inhibitors, recent studies have confirmed that plant PAs are involved in the acquisition of tolerance to multiple abiotic stresses (Gill & Tuteja, 2010), such as high and low temperatures, salinity, hypoxia and soil/atmospheric pollutants, including HMs (Chen et al, 2019; Gupta et al, 2013; Kuznetsov et al, 2006; Paul, Banerjee, & Roychoudhury, 2018; Rangan et al, 2014; Todorova et al, 2014).…”

Section: Pas—biosynthetic and Catabolic Pathways And Biological Functmentioning

confidence: 99%

“…The three main plant PAs appear to have different functions under abiotic stress. On sensitive plant species, Put content usually increases quickly as a response to changes in the environment, which reflects in a decreased (Spm + Spd)/Put ratio, being these changes usually accompanied by the generation of ROS, which, altogether, is considered as a stress signal (Groppa & Benavides, 2008; Paul et al, 2018; Zhao & Yang, 2008). In contrast, stress‐tolerant species and cultivars are usually able to maintain higher levels of Spd and Spm under stress, while Put levels remain relatively low, which could imply their higher resilience (Sánchez‐Rodríguez, Romero, & Ruiz, 2016).…”

Section: Pas—biosynthetic and Catabolic Pathways And Biological Functmentioning

confidence: 99%

Polyamines as key regulatory players in plants under metal stress—A way for an enhanced tolerance

Spormann

Soares

Teixeira

et al. 2021

Annals of Applied Biology

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Polyamine (PA) metabolism and functions have started to raise attention from plant scientists in the last years. PAs have been investigated for their involvement in plant cell signalling and protection, proving that alterations in their endogenous levels can affect plant growth, development and survival. The recognised roles of PAs in metal‐stressed plants are presented and discussed on a “case‐study” basis, for each metal. Bearing in mind that the contamination of soils by heavy metals (HMs) is a growing problem worldwide, it is important to find efficient mechanisms through which agricultural productivity and food quality are safeguarded in a scenario of increased pollution. Making cultivars more tolerant to HM‐stress, capable of detoxifying or accumulating them safely, is a goal that will most certainly benefit from researching the functions and applicability of PAs. To date, plant PAs have been recognised for their roles as membrane‐, protein‐ and nucleic acid‐stabilisers, as protectors of cellular integrity and photosynthetic machinery, as direct and indirect signalling agents, and as emerging members of the non‐enzymatic antioxidant system. Moreover, PAs are not only important in normal plant developmental processes but have also been suggested to induce stress priming, to act as epigenetic regulators of gene expression and to enhance the detoxification and vacuolar compartmentalization of HMs. Although the stress‐ameliorating effects of PAs have been widely studied for several abiotic stresses, not much is known regarding their effects on metal induced‐stress, except for Cd. This review summarises the available work on the effects of PAs in plants exposed to Cu, Cd, Fe, Mn, Cr, Ni, Hg, Al, Pb and Zn.

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Role of Polyamines in Mediating Antioxidant Defense and Epigenetic Regulation in Plants Exposed to Heavy Metal Toxicity

Cited by 30 publications

References 98 publications

Analysis of physiological and metabolite response of Celosia argentea to copper stress

Analysis of physiological and metabolite response of Celosia argentea to copper stress

Polyamine Action under Metal/Metalloid Stress: Regulation of Biosynthesis, Metabolism, and Molecular Interactions

Polyamines as key regulatory players in plants under metal stress—A way for an enhanced tolerance

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