2009
DOI: 10.1093/ndt/gfp427
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Role of podocytes in lupus nephritis

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Cited by 34 publications
(29 citation statements)
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“…In a study comparing the differences between LN class II with or without NS, the only distinguishable morphologic finding associated with NS was diffuse FPE, and proteinuria best correlated with podocytopathy rather than mesangial deposits (21). Therefore, it appears that podocytopathy occurring in MsP LN involves pathways independent of immune complex deposition and instead relates to direct podocyte injury (27,28). The fact that NS relapsed in the three patients with no glomerular immune deposits concurrent with extrarenal and serological activity strongly supports the idea that podocytopathy is associated with SLE, rather than the idea that SLE coexists with idiopathic MCD.…”
Section: Discussionmentioning
confidence: 99%
“…In a study comparing the differences between LN class II with or without NS, the only distinguishable morphologic finding associated with NS was diffuse FPE, and proteinuria best correlated with podocytopathy rather than mesangial deposits (21). Therefore, it appears that podocytopathy occurring in MsP LN involves pathways independent of immune complex deposition and instead relates to direct podocyte injury (27,28). The fact that NS relapsed in the three patients with no glomerular immune deposits concurrent with extrarenal and serological activity strongly supports the idea that podocytopathy is associated with SLE, rather than the idea that SLE coexists with idiopathic MCD.…”
Section: Discussionmentioning
confidence: 99%
“…In this context, podocytes may possess immunological properties as they express cytokine and chemokine receptors, produce inflammatory mediators, and upregulate the costimulatory molecule B7-1 via toll-like receptor-4 (TLR-4) signalling. 27 Recently, Machida et al 33 showed induction of TLR-9 expression in renal podocytes in childhood-onset active class IV LN, associated with reduced nephrin and podocin expression. TLR-9 may respond to CpG-DNA thus providing a hypothetical mechanism for DNA-containing immune complexes to promote podocyte injury in proliferative LN.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, podocytes also play critical role in the regulation of glomerular filtration and the immune response in human body. Growing evidence suggested that the damage of podocytes is the key of chronic renal pathological changes and both structure abnormal and malfunction of podocytes are of critical importance in the development of LN [1-2]. …”
Section: Introductionmentioning
confidence: 99%