Role of Platelets in Inflammation

Arman, Mònica; Payne, Holly; Ponomaryov, Tatyana; Brill, Alexander

doi:10.5772/60536

Cited by 15 publications

(14 citation statements)

References 168 publications

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“…Multiple inflammatory elements are present in platelets, which can activate innate immune cells and stimulate the endothelium. Platelets interact with leukocytes and support their interaction with the vessel wall, which enables their migration to the tissues (26). In various cancer types, platelets protect metastatic cancer cells from surveillance by natural killer (NK) cells.…”

Section: Discussionmentioning

confidence: 99%

The combination of serum calcium levels, neutrophil‑to‑lymphocyte ratio and platelet count in the prognosis of multiple myeloma: A retrospective cohort study and review of the literature

Han

Pham

et al. 2022

World Acad Sci J

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The prognosis of multiple myeloma (MM) can be determined by the serum calcium levels, the neutrophil-to-lymphocyte ratio (NLR) and the platelet count (PLT). The objective of the present study was to determine the influence of the combined prognostic index (CPI), which included the aforementioned three indices (serum calcium levels, NLR and PLT), on the survival rates of patients with MM. A total of 111 patients newly diagnosed with MM undergoing treatment were analyzed. The prognostic values for the survival times were determined at the time of pre-treatment. The patients with high serum calcium levels (2.665 mmol/l), a high NLR (2.245) and a low PLT (<150x10 9 /l) received a score of 1. Based on the scores obtained, the CPI was formed, in which the patients were grouped into a low-risk group (0-1 points), an intermediate-risk group (2 points) and a high-risk group (3 points). Univariate analysis demonstrated significant differences between the three CPI groups (P<0.001). Multivariate analysis indicated that the CPI was an independent prognostic factor for overall survival [intermediate-risk group: Hazard ratio (HR), 3.244; 95% confidence interval (CI), 1. 4.290; 95% CI, P<0.001]. This level of significance was also observed in the subgroups, which were divided according to the percentage of bone marrow plasma cells (≥30 or <30%) and age (≥65 or <65 years). On the whole, the present study demonstrates that the CPI determined by the high serum calcium levels, high NLR and low PLT may be used as an independent prognostic indicator for patients with MM.

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Section: Discussionmentioning

confidence: 99%

The combination of serum calcium levels, neutrophil‑to‑lymphocyte ratio and platelet count in the prognosis of multiple myeloma: A retrospective cohort study and review of the literature

Han

Pham

et al. 2022

World Acad Sci J

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“…Cross-talk between endothelial cells, leukocytes, and platelets is multi-directional and forms several positive feedback loops. Activation of endothelial cells recruits and activates leukocytes and platelets; leukocyte-derived molecules promote platelet-mediated fibrin deposition; activated platelets stimulate leukocytes to release chromatin that induces platelet aggregation on endothelium [163] . The upregulated adhesion molecules on the activated cells represent excellent targets for nanocarriers.…”

Section: Target Accessibilitymentioning

confidence: 99%

Targeting vascular inflammation through emerging methods and drug carriers

Nong

Glassman

Muzykantov

2022

Advanced Drug Delivery Reviews

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“…Beyond hemostasis and thrombosis, platelets play essential roles in multiple inflammation-related diseases and contribute to atherosclerosis, myocarditis, and ischemia-reperfusion injury. For instance, platelets can release inflammatory mediators, such as cytokines and damage-associated molecular patterns (DAMPs), upon activation to recruit immune cells and modulate inflammation at lesion sites [10,11].…”

Section: Introductionmentioning

confidence: 99%

Cyclophilin A Is Not Acetylated at Lysine-82 and Lysine-125 in Resting and Stimulated Platelets

Rosa

Butt

Hopper

et al. 2022

IJMS

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Cyclophilin A (CyPA) is widely expressed by all prokaryotic and eukaryotic cells. Upon activation, CyPA can be released into the extracellular space to engage in a variety of functions, such as interaction with the CD147 receptor, that contribute to the pathogenesis of cardiovascular diseases. CyPA was recently found to undergo acetylation at K82 and K125, two lysine residues conserved in most species, and these modifications are required for secretion of CyPA in response to cell activation in vascular smooth muscle cells. Herein we addressed whether acetylation at these sites is also required for the release of CyPA from platelets based on the potential for local delivery of CyPA that may exacerbate cardiovascular disease events. Western blot analyses confirmed the presence of CyPA in human and mouse platelets. Thrombin stimulation resulted in CyPA release from platelets; however, no acetylation was observed—neither in cell lysates nor in supernatants of both untreated and activated platelets, nor after immunoprecipitation of CyPA from platelets. Shotgun proteomics detected two CyPA peptide precursors in the recombinant protein, acetylated at K28, but again, no acetylation was found in CyPA derived from resting or stimulated platelets. Our findings suggest that acetylation of CyPA is not a major protein modification in platelets and that CyPA acetylation is not required for its secretion from platelets.

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Role of Platelets in Inflammation

Cited by 15 publications

References 168 publications

The combination of serum calcium levels, neutrophil‑to‑lymphocyte ratio and platelet count in the prognosis of multiple myeloma: A retrospective cohort study and review of the literature

The combination of serum calcium levels, neutrophil‑to‑lymphocyte ratio and platelet count in the prognosis of multiple myeloma: A retrospective cohort study and review of the literature

Targeting vascular inflammation through emerging methods and drug carriers

Cyclophilin A Is Not Acetylated at Lysine-82 and Lysine-125 in Resting and Stimulated Platelets

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