Role of Platelets in Acute Lung Injury After Extracorporeal Circulation in Cardiac Surgery Patients: A Systemic Review

Bhushan, Shanti; Xiao, Zhi; Zhao, Fengying; Feng, Qianru; Gao, Ke

doi:10.1016/j.cpcardiol.2021.101088

Cited by 7 publications

(3 citation statements)

References 57 publications

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“…Social isolation, which is associated with age, may explain the prominent psychological disorders and impaired social support in patients with CHF (Yang et al, 2023). Considering the significant impact of psychological and environmental factors on patients beyond somatic symptoms, there is a growing call to improve the psychological and social functioning of patients alongside the management of the primary disease (Sandeep et al, 2023). Our findings further reaffirm and emphasize this appeal.…”

Section: Discussionmentioning

confidence: 99%

Network analysis of symptoms, physiological, psychological and environmental risk factors based on unpleasant symptom theory in patients with chronic heart failure

Wang,

Xu,

et al. 2024

Int J of Nursing Practice

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BackgroundSomatic symptoms and related factors in patients with chronic heart failure have been extensively researched. However, more insight into the complex interconnections among these constructs is needed, as most studies focus on them independently from each other.AimsThe aim of this study is to gain a comprehensive understanding of how somatic symptoms and related factors are interconnected among patients with chronic heart failure.MethodsA total of 379 patients were enrolled. Network analysis was used to explore the interconnections among the somatic symptoms and related risk factors.ResultsThe four core symptoms of chronic heart failure were daytime dyspnea, dyspnea when lying down, fatigue and difficulty sleeping. Within the network, the edge weights of depression–anxiety, subjective social support–objective social support, and subjective social support–social support availability were more significant than others. Among physiological, psychological and environmental factors, the edge weights of NYHA–dyspnea, depression–difficulty sleeping, and social support availability–dyspnea when lying down were more significant than others. Depression and anxiety had the highest centrality, indicating stronger and closer connections with other nodes.ConclusionsPsychological and environmental factors stood out in the network, suggesting the potential value of interventions targeting these factors to improve overall health.

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Section: Discussionmentioning

confidence: 99%

Network analysis of symptoms, physiological, psychological and environmental risk factors based on unpleasant symptom theory in patients with chronic heart failure

Wang,

Xu,

et al. 2024

Int J of Nursing Practice

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“…CPB is a widely known risk factor for the occurrence of postoperative ARDS [8]. It is generally recognized that exposure of blood to abnormal surfaces, as in the case of CPB, can trigger exaggerated in ammatory response and induce the lung dysfunction even occurring ARDS in patients undergoing cardiac surgery [13]. Many previous studies paid attention to the mechanism of ARDS induced by CPB including activation of complement, abnormal immune reaction to protamine mediated by IgE, and dysfunction of platelets [7,14].…”

Section: Discussionmentioning

confidence: 99%

Association between cardiopulmonary bypass time and clinical outcomes among patients with acute respiratory distress syndrome after cardiac surgery

Liu

Huang

et al. 2023

Preprint

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Background:Cardiopulmonary bypass (CPB) can lead to lung injury and even acute respiratory distress syndrome (ARDS) through triggering systemic inflammatory response. The objective of this study was to investigate the impact of CPB time on clinical outcomes in patients with ARDS after cardiac surgery. Methods:Totally, patients with ARDS after cardiac surgery in Beijing Anzhen Hospital from January 2005 to December 2015 were retrospectively included and were further divided into three categories according to CPB time during operation. The primary endpoints were the ICU mortality and in-hospital mortality, and ICU and hospital stay. Restricted cubic spline (RCS), logistic regression, cox regression model, and receiver operating characteristic (ROC) curve were adopted to explore the relationship between CPB time and clinical endpoints. Results: Of the 54217 patients who underwent cardiac surgery during the above period, 210 patients developed ARDS after surgery and were finally included. The ICU mortality and in-hospital mortality were 21.0% and 41.9% in all ARDS patients after cardiac surgery respectively. Patients in category3 (CPB time ≥ 173 minutes) had longer ICU stay (P=0.011), higher ICU (P<0.001) mortality and in-hospital(P=0.002) mortality compared with those in category1 (CPB=0). For each ten minutes increment in CPB time, the hazards of a worse outcome increased by 13.3% for ICU mortality and 9.3% for in-hospital mortality after adjusting for potential factors.ROC curves showed CPB time presented more satisfactory power to predict mortality compared with APCHEII score. The optimal cut-off value of CPB time were 160.5 minutes for ICU mortality and in-hospital mortality. Conclusion: Our findings firstly revealed the quantitative relationship between CPB time and clinical outcomes in patients with ARDS after cardiac surgery. Longer time of CPB was associated with poorer clinical outcomes, and could be served as an indicator to predict short-term mortality in patients with ARDS after cardiac surgery.

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“…ALI is characterized by acute hypoxic respiratory failure caused by injury of alveolar epithelial cells [9]. ALI is caused by inflammation; however, understanding the pathogenesis of ALI requires further study [10]. Currently, there are no effective treatments for the severe stage of ALI (oxygenation index < 200).…”

Section: Discussionmentioning

confidence: 99%

Abietic acid attenuates LPS-induced acute lung injury by restoring Th17/Treg balance

Li¹,

Liu²,

Liu³

et al. 2022

Trop. J. Pharm Res

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Purpose: To investigate the mechanism of action and effects of abietic acid (AA) in a mouse acute lung injury (ALI) model. Methods: A mouse ALI model was established by lipopolysaccharide (LPS) induction. Lung tissues were examined for histological alterations and scored based on the degree of injury. Myeloperoxidase (MPO), IL-6, IL-1β, and TNF-α levels were measured by enzyme-linked immunosorbent assay (ELISA) while the numbers of Th17 and Treg cells were assessed by immunofluorescence. Protein expression levels of p-STAT3, p-STAT5, RORrt, and FOXP3 were analyzed by immunoblot assay. Expression of peroxisome proliferator-activated receptor γ (PPARγ) was assessed by immunoblot. Results: AA ameliorated LPS-induced lung injury in mice. Furthermore, AA ameliorated LPS-induced pneumonia in mice (p < 0.05) and restored Th17/Treg balance and Th17/Treg transcription factor expression that was altered by LPS induction. AA also activated PPARγ expression to restore Th17/Treg balance (p < 0.05). Conclusion: The results indicate that AA attenuates LPS-induced ALI in mice by restoring Th17/Treg balance. Thus, AA is a potential drug for the management of ALI; however, AA must first be evaluated in clinical studies.

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Role of Platelets in Acute Lung Injury After Extracorporeal Circulation in Cardiac Surgery Patients: A Systemic Review

Cited by 7 publications

References 57 publications

Network analysis of symptoms, physiological, psychological and environmental risk factors based on unpleasant symptom theory in patients with chronic heart failure

Network analysis of symptoms, physiological, psychological and environmental risk factors based on unpleasant symptom theory in patients with chronic heart failure

Association between cardiopulmonary bypass time and clinical outcomes among patients with acute respiratory distress syndrome after cardiac surgery

Abietic acid attenuates LPS-induced acute lung injury by restoring Th17/Treg balance

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