Role of platelet-rich plasma in soft and hard connective tissue healing: an evidence-based review from basic to clinical application

Moshiri, Ali; Oryan, Ahmad

doi:10.13172/2050-2303-2-1-326

Cited by 33 publications

(89 citation statements)

References 93 publications

(181 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The choice of the xenogeneic PRP presentation adopted in the present study contradicts the main scientific observations described 24,26 . According to these authors, xenogeneic PRP has a high immunogenic factor when compared to allogeneic and autogenic presentations.…”

Section: ■ Discussioncontrasting

confidence: 79%

“…Contrary to previously mentioned 24,26 , no histopathological features were suggested that suggested an increase in bone resorption mediated by immunogenicity by xenogenic PRP. However, the preliminary result is considered and reliable inferences regarding the immune response to xenogeneic PRP are not possible.…”

Section: ■ Discussioncontrasting

confidence: 74%

“…This biomaterial was sought because it did not trigger a local inflammatory response, whose degradation time does not interfere in the bone repair process and presents mechanical properties adequate for application in bone failures, as previously described in contemporary studies [23][24][25][26] .…”

Section: ■ Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Allogeneic mesenchymal stem cells and xenogenic platelet rich plasma, associated or not, in the repair of bone failures in rabbits with secondary osteoporosis

et al. 2017

View full text Add to dashboard Cite

Allogeneic mesenchymal stem cells and xenogenic platelet rich plasma, associated or not, in the repair of bone failures in rabbits with secondary osteoporosis¹ 9-Experimental SurgeryActa Cir Bras. 2017;32(9):767-780 AbstractPurpose: To assess the efficacy of allogeneic mesenchymal stem cells and xenogenic platelet rich plasma in the treatment of bone failure of osteoporotic rabbits secondary to estrogenic deprivation and iatrogenic hypercortisolism. Methods: Eight female rabbits underwent ovarian resection and corticoid therapy to induce clinical status of osteoporosis. Four failures were produced in the tibiae, with each failure being treated with hemostatic sponge, allogenic mesenchymal stem cells, xenogenic plateletrich plasma and the association between both. The animals were divided into two groups, evaluated radiographically and histopathologically at 30 and 60 days post treatment. Results: A radiographically confirmed consolidation of bone failures treated with allogeneic mesenchymal stem cells, associated with the histopathological image of mature and immature bone tissue, without evidence of osteopenia, was compared with the other groups, in which radiolucent failures with osteopenia and fibrosis were still present, denoting the satisfactory effect of the first treatment in detriment to the others. Conclusion:The treatment of bone failures of rabbits with secondary osteoporosis with allogeneic mesenchymal stem cells induced greater bone consolidation with mature and immature bone tissue production (p<0.01), when compared to the other treatments.

show abstract

Section: ■ Discussioncontrasting

confidence: 79%

Section: ■ Discussioncontrasting

confidence: 74%

See 1 more Smart Citation

Allogeneic mesenchymal stem cells and xenogenic platelet rich plasma, associated or not, in the repair of bone failures in rabbits with secondary osteoporosis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Tissue engineering is another option which has been introduced in the last decade and currently it is the final option in managing large and massive tendon and ligament injuries [22][23][24][25][26][27][28][29][30][31][32]. Tissue engineering is defined as "a process that affects the structure and architecture of any viable and nonviable tissue with the aim to increase the effectiveness of the construct in biologic environments" [12].…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…All these available options have their own significant limitations [3]. Tissue engineering is a newer option and is divided into four categories of scaffold, healing promotive factors, stem cells and gene therapy [22][23][24][25][26][27][28][29][30][31][32]. Using each or a combination of them have provided the new insights in orthopedic surgery [12,24,[30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Tendon and Ligament Tissue Engineering, Healing and Regenerative Medicine

Moshiri¹,

Oryan²

2013

J Sports Med Doping Stud 2013

102

View full text Add to dashboard Cite

Tendons transmit forces from muscle to bone and provide the joint function and ligaments transmit forces from bone to bone and provide joint stability. Tendon and ligament injuries have high incidence and management of tendon and ligament injuries is technically demanding because the healing response of these soft connective tissues is low. In addition, number of the available options to be considered as tissue replacement for large defects is low and healing of tendon and ligaments is faced to significant limitations. Among the available options, autografts are still gold standard but all the auto-allo and xenografts have their own limitations. Tissue engineering is a newer option but it is still primitive to be applicable extensively, in clinical setting. Tissue engineering could be divided into four categories including scaffolds, healing promotive factors, stem cells and gene therapy. To be able to have a good judgment regarding the management of tendon and ligament injuries, it is crucial to have a basic knowledge of tendon and ligament healing and regeneration. In this review, we discussed various types of tendon and ligament injuries and their incidence, and introduced the available and future options in managing large and massive tendon and ligament injuries. We specifically discussed the tissue engineering and it's advantageous and disadvantageous. To give a better clarification for the readers, we described different phases and cascades of tendon and ligament healing, modeling and remodeling, host-graft interaction after implantation of the graft and various types of prosthetic implants and finally provided some suggestions for the future investigations.

show abstract

Bone morphogenetic proteins: A powerful osteoinductive compound with non‐negligible side effects and limitations

et al. 2014

View full text Add to dashboard Cite

Healing and regeneration of large bone defects leading to non-unions is a great concern in orthopedic surgery. Since auto- and allografts have limitations, bone tissue engineering and regenerative medicine (TERM) has attempted to solve this issue. In TERM, healing promotive factors are necessary to regulate the several important events during healing. An ideal treatment strategy should provide osteoconduction, osteoinduction, osteogenesis, and osteointegration of the graft or biomaterials within the healing bone. Since many materials have osteoconductive properties, only a few biomaterials have osteoinductive properties which are important for osteogenesis and osteointegration. Bone morphogenetic proteins (BMPs) are potent inductors of the osteogenic and angiogenic activities during bone repair. The BMPs can regulate the production and activity of some growth factors which are necessary for the osteogenesis. Since the introduction of BMP, it has added a valuable tool to the surgeon's possibilities and is most commonly used in bone defects. Despite significant evidences suggesting their potential benefit on bone healing, there are some evidences showing their side effects such as ectopic bone formation, osteolysis and problems related to cost effectiveness. Bone tissue engineering may create a local environment, using the delivery systems, which enables BMPs to carry out their activities and to lower cost and complication rate associated with BMPs. This review represented the most important concepts and evidences regarding the role of BMPs on bone healing and regeneration from basic to clinical application. The major advantages and disadvantages of such biologic compounds together with the BMPs substitutes are also discussed.

show abstract

Role of platelet-rich plasma in soft and hard connective tissue healing: an evidence-based review from basic to clinical application

Cited by 33 publications

References 93 publications

Allogeneic mesenchymal stem cells and xenogenic platelet rich plasma, associated or not, in the repair of bone failures in rabbits with secondary osteoporosis

Allogeneic mesenchymal stem cells and xenogenic platelet rich plasma, associated or not, in the repair of bone failures in rabbits with secondary osteoporosis

Tendon and Ligament Tissue Engineering, Healing and Regenerative Medicine

Bone morphogenetic proteins: A powerful osteoinductive compound with non‐negligible side effects and limitations

Contact Info

Product

Resources

About