Role of Platelet-Mediated Cytoadherence and Chemokines Release in Severe Malaria

In vivo effect of chronic nicotine exposure on outcome of Plasmodium berghei ANKA malaria

“…Its occurrence is when activated platelets during the course of malaria infection [38] release microparticles that modulate the sequestration of parasitized erythrocytes (PRBC) on the brain endothelium, platelets aggregate [39][40][41]. Mechanism of platelets induced CM is, assumed that through contact dependent pro-apoptotic effect of platelets on TNF-α activated human brain micro-vascular endothelial cells (HBEC) [42].…”