Role of platelet indices in prediction of preeclampsia

Temür, Muzaffer; Taşgöz, Fatma Nurgül; Çift, Tayfur; Serpim, Gülçin; Üstünyurt, Emin

doi:10.5603/gp.a2021.0056

Cited by 6 publications

(6 citation statements)

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“…(31,32) In line with the increase in IPF, the increase in MPV value reflects an increase in young platelets of larger size, indicating an active turnover of platelet production in the bone marrow due to peripheral consumption. (23,33) The mean MPV value in this study showed that the normotensive pregnant women group (10.41±0.76 fL) was lower than the preeclampsia group (11.32±1.2 fL) with a significant difference (p=0.002).…”

Section: Discussionmentioning

confidence: 51%

“…An insignificant decrease in platelets despite an increase in peripheral platelet consumption may be possible due to an increase in bone marrow platelet production, as evidenced by an increase in IPF values. (20,23) The median serum transthyretin levels of normotensive pregnancies (11 (6-30) mg/dL) in this study showed higher values than preeclampsia patients (9 (5-18) mg/dL) with a statistically significant difference (p=0.008). This is in line with previous studies, which showed the median serum transthyretin in severe preeclampsia patients was significantly lower than the median transthyretin of normotensive pregnancies.…”

Section: Discussionmentioning

confidence: 57%

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Transthyretin, Immature Platelet Fraction, and Mean Platelet Volume in Normotensive and Preeclampsia Pregnancy

et al. 2022

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BACKGROUND: Transthyretin protein experiences misfolding and aggregation in preeclampsia due to placental ischemia and inflammation. Placental endothelial damage occurring in preeclampsia stimulates the production of larger young platelets in the bone marrow and can be reflected by an increase in the immature platelet fraction (IPF) and mean platelet volume (MPV). Since the change in these markers in preeclampsia remains controversial, this study was conducted to analyze the differences in levels of transthyretin, IPF, and MPV as easily accessible markers in normotensive and preeclampsia pregnancies.METHODS: Total subjects included in this study were 32 normotensive and 26 preeclampsia pregnant woman. The measurement of serum transthyretin level was using enzyme-linked immunosorbent assay (ELISA) method. Meanwhile, IPF and MPV levels were measured by using a hematology analyzer with flowcytometry method. Data was statistically analyzed using unpaired T-test and Mann-Whitney, with significancy of p<0.05.RESULTS: Median value of transthyretin in normotensive and preeclampsia pregnancy were 11 (6-30) mg/dL and 9 (5-18) mg/dL. The mean value of IPF in normotensive and preeclampsia pregnancy were 4.56±2.19% and 6.33±2.99%. Mean value of MPV in normotensive and preeclampsia pregnancy were 10.41±0.76 fL and 11.32±1.2 fL. There were significant differences in levels of transthyretin, IPF, and MPV between normotensive and preeclampsia pregnancies (p=0.008, p=0.017, and p=0.002, respectively).CONCLUSION: There are significant differences in transthyretin levels, IPF, and MPV values in normotensive and preeclampsia pregnancies. Therefore, serum transthyretin, IPF, and MPV can be developed as affordable parameters for the diagnosis of preeclampsia.KEYWORDS: preeclampsia, transthyretin, IPF, MPV

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 57%

Transthyretin, Immature Platelet Fraction, and Mean Platelet Volume in Normotensive and Preeclampsia Pregnancy

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“…3 A). A decrease in PC and/or an increase in MPV with a subsequent a decreased PC/MPV ratio have been previously has been suggested to be a predictor for the severity of PE [ 28 , 29 ].…”

Section: Resultsmentioning

confidence: 99%

Impairment of mitochondrial respiration in platelets and placentas: a pilot study in preeclamptic pregnancies

et al. 2022

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Preeclampsia (PE) is a major complication of pregnancy with partially elucidated pathophysiology. Placental mitochondrial dysfunction has been increasingly studied as major pathomechanism in both early- and late-onset PE. Impairment of mitochondrial respiration in platelets has recently emerged as a peripheral biomarker that may mirror organ mitochondrial dysfunction in several acute and chronic pathologies. The present study was purported to assess mitochondrial respiratory dys/function in both platelets and placental mitochondria in PE pregnancies. To this aim, a high-resolution respirometry SUIT (Substrate-Uncoupler-Inhibitor-Titration) protocol was adapted to assess complex I (glutamate + malate)- and complex II (succinate)-supported respiration. A decrease in all respiratory parameters (basal, coupled, and maximal uncoupled respiration) in peripheral platelets was found in preeclamptic as compared to healthy pregnancies. At variance, placental mitochondria showed a dichotomous behavior in preeclampsia in relation to the fetal birth weight. PE pregnancies with fetal growth restriction were associated with decreased in coupled respiration (oxidative phosphorylation/OXPHOS capacity) and maximal uncoupled respiration (electron transfer/ET capacity). At variance, these respiratory parameters were increased for both complex I- and II-supported respiration in PE pregnancies with normal weight fetuses. Large randomized controlled clinical studies are needed in order to advance our understanding of mitochondrial adaptive vs. pathological changes in preeclampsia.

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“…Platelet parameters, such as platelet counts (PCs), platelet distribution widths (PDWs), mean platelet volume (MPVs), and plateletcrits (Pcts), have been widely used in cardiovascular, inflammatory and autoimmune diseases patients to predict platelet function, destruction, and production (12)(13)(14)(15). Platelet activation and destruction are expected outcomes of PPCs (1,16,17). MPV, Pct, and PDW variations can be detected by new-born platelet production in the bone marrow and releases fresh and large platelets into the circulation were stimulated (16,18).…”

Section: Original Articlementioning

confidence: 99%

“…Platelet activation and destruction are expected outcomes of PPCs (1,16,17). MPV, Pct, and PDW variations can be detected by new-born platelet production in the bone marrow and releases fresh and large platelets into the circulation were stimulated (16,18). However, to some extent, these parameters fail to provide comprehensive information about the kinetics of platelet function.…”

Section: Original Articlementioning

confidence: 99%

Role of variation in platelet indices in pregnancy-related pathological complications and the prediction of postpartum hemorrhage: a case-control study

et al. 2022

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Background: Pregnancy-related pathological complications (PPCs) increase the risk of postpartum hemorrhage (PPH), Platelet activation and destruction are expected outcomes of PPCs. This study sought to compare the platelet indices of non-pregnant (NP) child-bearing aged women, healthy pregnant (HP) women, and women with PPCs, and investigate the use of these indices in PPH prediction.Methods: This retrospective clinical study included 260 NP child-bearing aged women and 119 pregnant women. Of the 119 pregnant patients, 69 had HPs and 50 suffered from PPCs. Further, 50 patients delivered with PPH. We compared the platelet counts (PCs), mean platelet volumes (MPVs), platelet distribution widths (PDWs), plateletcrits (Pcts), MPV ratios (PC/MPV and Pct/MPV), alpha angles (angles), and maximum amplitudes (MAs) of the patients using Sysmex XN10 hematology analyzer and TEG 5000Hemostasis analyzer system, respectively.Results: With the exception of PDW, there were significant differences in the platelet parameters of the NP, HP, and PPC patients (P<0.05). The intergroup comparison results showed that the NP patients differed significantly from the HP and PPC patients in terms of age, MA, PC, Pct, and Pct/MPV (P<0.0125).Further, the HP and PPC patients differed significantly in terms of Pct, MPV, PC/MPV, and Pct/MPV (P<0.0125). Additionally, the univariate analysis showed that in the PPC patients, low MPV values were strongly related to PPH [odds ratio (OR) =0.012, P=0.003; OR =0.331, P=0.047].Conclusions: Women with PPCs had significantly lower PC, Pct, PC/MPV and Pct/MPV values, but significantly higher MA and MPV values. PPHs were strongly related to PPC and low MPV values. A timely accurate diagnosis and evaluating MPV values may be useful in the prediction of PPH.

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Role of platelet indices in prediction of preeclampsia

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Ginekologia Polska" are listed in PubMed.

Cited by 6 publications

References 23 publications

Transthyretin, Immature Platelet Fraction, and Mean Platelet Volume in Normotensive and Preeclampsia Pregnancy

Transthyretin, Immature Platelet Fraction, and Mean Platelet Volume in Normotensive and Preeclampsia Pregnancy

Impairment of mitochondrial respiration in platelets and placentas: a pilot study in preeclamptic pregnancies

Role of variation in platelet indices in pregnancy-related pathological complications and the prediction of postpartum hemorrhage: a case-control study

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