Role of platelet biomarkers in inflammatory response

Chen, Yufei; Zhong, Haoxuan; Zhao, Yikai; Luo, Xinping; Gao, Wen

doi:10.1186/s40364-020-00207-2

Cited by 85 publications

(72 citation statements)

References 95 publications

(136 reference statements)

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“…Surprisingly, although the chain length of polyP may be a matter for further investigation, it has been reported that polyanions like polyP can form a complex with PF4 and that this complex activates platelets as does the PF4-heparin complex. 31,34 Platelets also release anti-inflammatory cytokines, such as IL-4 and IL-10, upon activation, 1 and thus platelet-rich plasma (PRP) has been clinically utilized as an antiinflammatory agent or a pain-releasing agent. 35 At present, it is difficult to predict the risk of PF4-polyP complex-induced thrombosis by the "autocrine" loop or by exposure to bacterial polyP after vaccination.…”

Section: Possible Platelet Activation and Thrombosis By Polypmentioning

confidence: 99%

“…Upon infection, platelets first bind to infectious pathogens, such as bacteria and viruses, secrete various immunoregulatory cytokines, and express receptors for mediating various immune effects and regulatory functions. 1 Platelets regulate macrophage functions, regulatory T cells, and secrete pro-resolving mediators. 2 However, their regulatory functions are not simple: both proinflammatory and anti-inflammatory regulations are included and modulated by the degree and the phase of injury and inflammation (for more details, see "4 Discussion section").…”

Section: Introductionmentioning

confidence: 99%

“…3 The spike protein recognizes and binds the host cell surface receptor, angiotensin-converting enzyme 2 (ACE2), and aids the entry of SARS-Cov-2 into host cells 3 , including platelets, and probably similar to influenza virus. 1,4,5 Initially, coronavirus infection elevates fibrinogen and D-dimer levels to evoke systemic hypercoagulability and frequent venous thromboembolic events. 6 This could be considered as a severe proinflammatory state, which consequently induces procoagulopathy through endothelial activation/damage.…”

Section: Introductionmentioning

confidence: 99%

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Platelet polyphosphate and SARS-Cov-2 mRNA-vaccine-induced inflammatory side effects: a pilot study

Uematsu

Sato

Aizawa

et al. 2021

Preprint

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Background: Platelets have recently been recognized as immune cells. Platelets first contact invading pathogens and then induce immune reactions in cooperation with white blood cells. Platelet polyphosphate (polyP), which is classically recognized as a thrombotic and hemostatic biomolecule, has recently attracted attention as a cytokine that modulates inflammation and is involved in intercellular communication between platelets and major immune cells. Objective: To determine the involvement of polyP in SARS-Cov-2-mRNA vaccine-induced immune responses, this pilot study examined the effects of mRNA vaccines on platelet polyP levels. Methods: Before and after vaccination (BNT162b2), blood samples were obtained from healthy, non-smoking individuals (relatively older male group, n=6 vs. younger female group, n=23), who did not have systemic diseases that required continuous treatment. Washed platelets were prepared and subjected to a fluorometric determination of platelet polyP levels using 4',6-diamidino-2-phenylindole. The side effects of vaccination were recorded as scores. Results: Compared with the male group, platelet polyP levels decreased in the relatively younger female group after the initial dose, while the side effect score increased in the female group after the second dose. Moderate correlation coefficients were observed between the reduction in polyP levels and the side effect scores or the original polyP levels. Conclusions: Despite being a pilot study using a small sample size, this study suggests the possibility that platelet polyP may suppress the side effects induced by the mRNA vaccines after the initial dose, but not the second dose, in relatively young female subjects who generally have high immune responsiveness.

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Section: Possible Platelet Activation and Thrombosis By Polypmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Platelet polyphosphate and SARS-Cov-2 mRNA-vaccine-induced inflammatory side effects: a pilot study

Uematsu

Sato

Aizawa

et al. 2021

Preprint

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“…They are recruited at the site of inflammation and they have the ability to release multiple proinflammatory cytokines which further recruit platelets. [3][4][5] respiratory distress and even convulsions and unconsciousness.…”

Section: Introductionmentioning

confidence: 99%

Thrombocytosis: a predictor of severity in children with lower respiratory tract infection

Chandrakala¹,

Patil²,

Kavya³

et al. 2021

Int J Contemp Pediatr

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Background: Community acquired pneumonia remains a significant cause of morbidity and mortality due to infection all over the world. Thrombocytes are known to be an essential part of immune response to various infectious agents. Platelet count elevated more than normal is often sign of severe pneumonia according to various studies.Methods: This is a retrospective study conducted in Kempegowda Institute of Medical Science, a tertiary care hospital in Bangalore with a study duration of 1 year. All children were classified into two groups based on platelet count that is with thrombocytosis and without thrombocytosis. Respiratory distress was defined as presence of tachypnoea, chest retractions, oxygen saturation <94% in room air. Children with respiratory distress were classified as severe pneumonia and those with no respiratory distress as non-severe pneumonia.Results: A total of 213 children were admitted with lower respiratory tract infection of which 35 children were excluded based on exclusion criteria. Of these 178 children 142 (80%) belonged to non-severe pneumonia group and 36 (20%) belonged to severe pneumonia group. Thrombocytosis is found in 31 (17%) children, 147 (82%) children had platelet count less than 4.5 lakhs/cu mm. Of these children with thrombocytosis 13 (42%) had non severe pneumonia and 18 (58%) had severe pneumonia. The p<0.0000001 which showed statistical significance, that is thrombocytosis was significantly associated with severity of pneumonia.Conclusions: Thrombocytosis can be considered as a marker of severity of pneumonia in day-to-day practice.

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“…Mean platelet volume (MPV) has been determined as marker of platelet activation in inflammatory process. 4,5 Changes in MPV will directly influence platelet distribution width (PDW) which indicate variation of platelet size. MPV and PDW value are readily available as platelet parameter in complete blood count, and this examination is routinely done in patients with COVID-19.…”

mentioning

confidence: 99%

The relation between mean platelet volume and platelet distribution width to COVID-19 severity

Nugraha¹,

Atmaja²,

Suryana³

et al. 2021

Int J Adv Med

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Background: Wide spectrum of clinical manifestation and severity of COVID-19 led to further studies to find a simple biomarker used to predict the severity of COVID-19. We investigated the role of mean platelet volume (MPV) and platelet distribution width (PDW), widely available parameters, as predictor of COVID-19 severity.Methods: We conducted a single center analytic observational study to evaluate the relationship between MPV and PDW values and COVID-19 severities. A total of 123 subjects of COVID-19 within October to December 2020 included in the analysis.Results: Analysis showed a statistically significant difference in MPV, PDW, and D-dimer between COVID-19 severities (p<0.001, p=0.002, and p<0.001). Correlation coefficient between MPV, PDW, and D-dimer with COVID-19 severity were 0.28 (p=0.002); 0.22 (p<0.001), and 0.81 (p<0.001), but there’s no correlation between MPV (p=0.176) and PDW (p=0.383) with D-dimer. The AUC value of the ROC curve of MPV, PDW and D-dimer in predicting severity was 79% (p=0.001, 95% CI: 0.696-0.885), 72.5% (p<0.001, 95% CI: 0.598-0.852), and 97% (p<0.001, 95% CI: 0.937-1.00).Conclusions: This study found a relationship between MPV and PDW values on the severity of COVID-19. There’s no relationship of MPV and PDW to D-dimer concentration.

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Role of platelet biomarkers in inflammatory response

Cited by 85 publications

References 95 publications

Platelet polyphosphate and SARS-Cov-2 mRNA-vaccine-induced inflammatory side effects: a pilot study

Platelet polyphosphate and SARS-Cov-2 mRNA-vaccine-induced inflammatory side effects: a pilot study

Thrombocytosis: a predictor of severity in children with lower respiratory tract infection

The relation between mean platelet volume and platelet distribution width to COVID-19 severity

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