Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis

Caplan, Michael S.; Sun, Xiaoming; Hsueh, Wei; Hageman, Joseph R

doi:10.1016/s0022-3476(05)80661-4

Cited by 288 publications

(164 citation statements)

References 23 publications

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“…The PAF-AH activity in the plasma, which does not significantly differ from that in the serum (Kosaka et al 2000), varies in such pathological conditions as hyperlipidemia, cardiovascular diseases, stroke, rheumatoid arthritis, sepsis, and asthma. This activity has also been observed to decrease in patients with neonatal necrotizing enterocolitis (Caplan et al 1990). Regarding inflammatory bowel disease (IBD), this activity has been found to decrease in CD patients in comparison to controls in Sweden (Kald et al 1996), but the level showed no difference between UC patients and controls in Japan (Nakamura et al 2002).…”

confidence: 86%

Diagnostic Value of the Serum Platelet-Activating Factor Acetylhydrolase Activity in Inflammatory Bowel Disease

Oshimoto

Okamura

Iida

et al. 2005

Tohoku J. Exp. Med.

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confidence: 86%

Diagnostic Value of the Serum Platelet-Activating Factor Acetylhydrolase Activity in Inflammatory Bowel Disease

Oshimoto

Okamura

Iida

et al. 2005

Tohoku J. Exp. Med.

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“…Studies from our lab and others have shown that PAF plays an important role in the pathophysiology of intestinal inflammation and NEC in adult rats; for example: 1) exogenous PAF given intravenously results in ischemic bowel necrosis [12], 2) endotoxin, hypoxia, or TNFinduced intestinal injury can be prevented by PAF receptor antagonists [13][14][15], 3) endotoxin and hypoxia stress increases intestinal PAF content [13]. Additional experiments have evaluated the importance of PAF in neonatal rats using the typical risk factors of NEC, including asphyxia and formula feeding [16].…”

Section: The Role Of Platelet Activating Factor Homeostasismentioning

confidence: 99%

“…TLR4, the receptor for LPS, has been shown to take part in NEC pathogenesis [73,82], causes enterocyte apoptosis [101] and defective enterocyte migration [82]. Furthermore, TLR4 activation leads to induction of inflammatory molecules such as TNFα [102] and nitric oxide (NO) [103]; both of these molecules have been shown to be involved in NEC pathogenesis [15,81,104] and have been shown to be pro-apoptotic for enterocytes [81,105]. It is notable that other GPCRs that are closely related to PAFR may impart either pro or anti-apoptotic signals on enterocytes as discussed above [41, 99,100] signaling in other cell types that can actively promote inflammation such as PMN [106] and lymphocytes [108].…”

Section: Pro-apoptotic Signaling In Necmentioning

confidence: 99%

Intestinal Epithelial Cell Apoptosis, Immunoregulatory Molecules, and Necrotizing Enterocolitisb

Jilling¹

2012

J Clin Cell Immunol

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Necrotizing enterocolitis is one of the most severe, life-threatening consequences of premature birth, affecting 5-15% of premature neonates with birth weights <1,500 grams. Many lines of evidence suggest a role for the dysregulation of enterocyte apoptosis in NEC pathogenesis. In addition to apoptosis, the roles of several inflammatory mediators such as platelet-activating factor, IL-8, TNFα and endotoxin have been shown to be pathogenic. Receptors for these ligands and downstream cellular signaling pathways, such as mitochondrial injury-induced caspase activation and NFĸB-mediated transcriptional regulation are thought to be involved in the mechanisms of mucosal injury in NEC. In this review, we attempt to summarize the role of enterocyte apoptosis in NEC along with an analysis of the connection between inflammatory signaling and apoptosis in this disease.

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“…76 Elevated concentrations of PAF have been found in newborn babies with NEC, while levels of the enzyme that provokes its hydrolysis (acetylhydrolase) were reduced. 77 Human milk, and not bovine milk, is an important source of enzymes that lead to PAF hydrolysis. Another important datum is that human milk contains elevated levels of EGF, which cannot be found in commercial formulae.…”

Section: Maternal Breastmilkmentioning

confidence: 99%

Avanços em enterocolite necrosante

Oliveira¹,

Miyoshi²

2005

J. Pediatr. (Rio J.)

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Suggested citation: de Oliveira ND, Miyoshi MH. Advances in necrotizing enterocolitis. J Pediatr (Rio J). 2005;81(1 Suppl):S16-S22. AbstractObjective: To evaluate recently reported findings on necrotizing enterocolitis, paying particular attention to pathogenesis, management and preventative strategies.Data sources: The articles covered in this report consist of randomized and quasi-randomized trials, case control studies, meta-analyses and reviews published recently. Certain other articles were also included because of their utmost importance to the subject.Results: Necrotizing enterocolitis remains a major cause of morbidity and mortality in preterm infants. Those who are born with intra-uterine-growth retardation are at a several-fold increased risk. Possible pathophysiologic processes beginning in utero and continuing after birth are discussed in this review. Other factors involved in the process are related to the role of arginine and the production of intestinal nitric oxide and the action of epidermal growth factor in the regulation of cell regeneration. Perforated necrotizing enterocolitis is a complex surgical problem; definitive evidence-based guidelines for the best approach are yet to be determined. After surgery, although residual small bowel length and the presence of the ileo-cecal valve remain important predictors of duration of parenteral nutrition in infants, other factors, such as the early use of breast milk or amino acid-based formula, may also play a role in intestinal re-adaptation. Prevention strategies have centered on feeding practices and emerging experiments such as amino acid supplementation, are also discussed. Conclusion:Significant results in terms of mortality and morbidity will be achieved through better understanding of necrotizing enterocolitis pathogenesis and clinical and surgical management in addition to the employment of preventative strategies.J Pediatr (Rio J). 2005;81(1 Suppl):S16-S22: Necrotizing enterocolitis, prematurity, short bowel syndrome.

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Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis

Cited by 288 publications

References 23 publications

Diagnostic Value of the Serum Platelet-Activating Factor Acetylhydrolase Activity in Inflammatory Bowel Disease

Diagnostic Value of the Serum Platelet-Activating Factor Acetylhydrolase Activity in Inflammatory Bowel Disease

Intestinal Epithelial Cell Apoptosis, Immunoregulatory Molecules, and Necrotizing Enterocolitisb

Avanços em enterocolite necrosante

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