Role of plasma homocysteine levels and MTHFR polymorphisms on IQ scores in children and young adults with epilepsy treated with antiepileptic drugs

Rosa, Gabriella Di; Lenzo, Patrizia; Parisi, E.; Neri, Milena; Guerrera, Silvia; Nicotera, Antonio Gennaro; Alibrandi, Angela; Germanò, Eva; Caccamo, Daniela; Spanò, Maria; Tortorella, Gaetano

doi:10.1016/j.yebeh.2013.09.034

Cited by 12 publications

(8 citation statements)

References 15 publications

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“…In adolescents with epilepsy, there was no relationship between the plasma Hcy levels and cognitive scores, even though the Hcy levels were significantly higher in patients with epilepsy compared to healthy subjects (95). Similarly, there was no association between the plasma Hcy levels and the MMSE or SKT scores in a sample of geriatric patients with multiple co-morbid conditions (96).…”

Section: Other Diseasesmentioning

confidence: 88%

Homocysteine and cognition: A systematic review of 111 studies

Setién-Suero

Suárez-Pinilla

et al. 2016

Neuroscience & Biobehavioral Reviews

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Section: Other Diseasesmentioning

confidence: 88%

Homocysteine and cognition: A systematic review of 111 studies

Setién-Suero

Suárez-Pinilla

et al. 2016

Neuroscience & Biobehavioral Reviews

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“…Vitamin B-12 deficiency has been implicated in an increased occurrence and severity of neurodevelopmental disorders (37) and psychiatric conditions such as Alzheimer disease, schizophrenia (38), autism (39), depression (40,41), and epileptic conditions (42), based on neuroimaging and clinical and epidemiologic studies. Several systematic reviews have been conducted to examine the role of vitamin B-12 and other B vitamins in cognitive decline, dementia, and neuropsychiatric conditions.…”

Section: Introductionmentioning

confidence: 99%

Vitamin B-12 and Cognition in Children

Venkatramanan¹,

Armata²,

Strupp

et al. 2016

Advances in Nutrition

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Vitamin B-12 is essential for brain development, neural myelination, and cognitive function. Inadequate vitamin B-12 status during pregnancy and early childhood has been associated with adverse child health outcomes, including impaired cognitive development. However, the underlying mechanisms have not been elucidated. This review was conducted to examine the evidence that links vitamin B-12 and cognition in children. The search strategy resulted in 17 studies: 3 cross-sectional, 1 case-control, and 12 cohort studies, and 1 randomized trial. Cognitive processes assessed included attention, memory, and perception. Developmental outcomes, academic performance, and intelligence quotient were also considered. Despite the high prevalence of vitamin B-12 insufficiency and associated risk of adverse cognitive outcomes in children, to our knowledge, no studies to date have been conducted to examine the effects of vitamin B-12 supplementation on cognition in children. The role of vitamin B-12 in the etiology of child cognitive outcomes needs to be elucidated to inform public health interventions. Adv Nutr 2016;7:879-88.

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“…However, less is known about the relationship between cognitive function in children and homocysteine levels. In a cohort of children with epilepsy, high homocysteine levels were associated with the 677T allele, but not with IQ (Di Rosa et al, 2013). Short-term supplementation of folate in children with low folate levels decreased homocysteine levels, but did not influence cognitive performance (Rauh-Pfeiffer, et al, 2014).…”

Section: Discussionmentioning

confidence: 98%

Methylation polymorphism influences practice effects in children during attention tasks

Voelker

Sheese

Rothbart

et al. 2016

Cognitive Neuroscience

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Epigenetic mechanisms mediate the influence of experience on gene expression. Methylation is a principal method for inducing epigenetic effects on DNA. In this paper, we examine alleles of the methylenetetrahydrofolate reductase (MTHFR) gene that vary enzyme activity, altering the availability of the methyl donor and thus changing the efficiency of methylation. We hypothesized that alleles of the MTHFR gene would influence behavior in an attention related task in conjunction with genes known to influence attention. We found that 7-year-old children homozygous for the C allele of MTHFR in interaction with the catechol O-methyltransferase (COMT) gene showed greater improvement in overall reaction time (RT) and in conflict resolution with practice on the Attention Network Test (ANT). This finding indicates that methylation may operate on or through genes that influence executive network operation. However, MTHFR T allele carriers showed faster overall RT and conflict resolution. Some children showed an initial improvement in ANT RT followed by a decline in performance, and we found that alleles of the dopamine beta-hydroxylase (DBH) gene were related to this performance decline. These results suggest a genetic dissociation between improvement while learning a skill and reduction in performance with continued practice.

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Role of plasma homocysteine levels and MTHFR polymorphisms on IQ scores in children and young adults with epilepsy treated with antiepileptic drugs

Cited by 12 publications

References 15 publications

Homocysteine and cognition: A systematic review of 111 studies

Homocysteine and cognition: A systematic review of 111 studies

Vitamin B-12 and Cognition in Children

Methylation polymorphism influences practice effects in children during attention tasks

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