Role of plant <i>CBP</i>/<i>p300‐like</i> genes in the regulation of flowering time

Han, Soon Woo; Song, Ju-Dong; Noh, Yoo‐Sun; Noh, Bosl

doi:10.1111/j.1365-313x.2006.02939.x

Cited by 88 publications

(104 citation statements)

References 61 publications

(154 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Arabidopsis BRM gene has been reported to be involved in numerous aspects of plant growth and development (Hurtado et al, 2006;Kwon et al, 2006). Han et al (2007) demonstrated that, in Arabidopsis, several genes encoding histone acetyltransferase play a role in regulating plant growth and flowering time. We have previously shown that the molecular behavior of GIF1 proteins is similar to that of SYT, including their existence as nuclear speckles and transcriptional activation activities (Kim and Kende, 2004).…”

Section: Gif Genes Have Functional Redundancy In Determining Organ Simentioning

confidence: 99%

The ArabidopsisGRF-INTERACTING FACTORGene Family Performs an Overlapping Function in Determining Organ Size as Well as Multiple Developmental Properties

et al. 2009

View full text Add to dashboard Cite

Previously, the GRF-INTERACTING FACTOR1 (GIF1)/ANGUSTIFOLIA3 (AN3) transcription coactivator gene, a member of a small gene family comprising three genes, was characterized as a positive regulator of cell proliferation in lateral organs, such as leaves and flowers, of Arabidopsis (Arabidopsis thaliana). As yet, it remains unclear how GIF1/AN3 affects the cell proliferation process. In this study, we demonstrate that the other members of the GIF gene family, GIF2 and GIF3, are also required for cell proliferation and lateral organ growth, as gif1, gif2, and gif3 mutations cause a synergistic reduction in cell numbers, leading to small lateral organs. Furthermore, GIF1, GIF2, and GIF3 overexpression complemented a cell proliferation defect of the gif1 mutant and significantly increased lateral organ growth of wild-type plants as well, indicating that members of the GIF gene family are functionally redundant. Kinematic analysis on leaf growth revealed that the gif triple mutant as well as other strong gif mutants developed leaf primordia with fewer cells, which was due to the low rate of cell proliferation, eventually resulting in earlier exit from the proliferative phase of organ growth. The low proliferative activity of primordial leaves was accompanied by decreased expression of cell cycle-regulating genes, indicating that GIF genes may act upstream of cell cycle regulators. Analysis of gif double and triple mutants clarified a previously undescribed role of the GIF gene family: gif mutants had small vegetative shoot apical meristems, which was correlated with the development of small leaf primordia. gif triple mutants also displayed defective structures of floral organs. Taken together, our results suggest that the GIF gene family plays important roles in the control of cell proliferation via cell cycle regulation and in other developmental properties that are associated with shoot apical meristem function.

show abstract

Section: Gif Genes Have Functional Redundancy In Determining Organ Simentioning

confidence: 99%

The ArabidopsisGRF-INTERACTING FACTORGene Family Performs an Overlapping Function in Determining Organ Size as Well as Multiple Developmental Properties

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Chromatin immunoprecipitation (ChIP) was performed as described by Han et al (2007) using 14-to 16-day-old seedlings. Seedlings were vacuum infiltrated with 1% formaldehyde for cross-linking and ground in liquid nitrogen after quenching the cross-linking process.…”

Section: Chip Assaymentioning

confidence: 99%

Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci

Song

Noh

2012

Molecules and Cells

Self Cite

View full text Add to dashboard Cite

“…There were 2 reports demonstrated that the HAC family genes promote flower by regulating the expression of the FLC. 9,10 Concurrently with the 2 groups, we found that hac1-involved mutants were significantly lateflowering compared with the WT plant. We measured the flowering time of all the hac mutant combinations grown under the long day condition (16h light/8h dark).…”

Section: W Ith Intrinsic Acetyltransferasementioning

confidence: 82%

“…In addition to lateflowering and ethylene-hypersensitive, hac1-involved mutants displayed multiple morphological and developmental defects, such as short primary root, small plant size, short filament, and petal. [9][10][11] Here we show that all the hac1-involved mutants displayed small, dark green, wrinkly, and indented rosette leaf phenotypes (Fig. 1).…”

Section: W Ith Intrinsic Acetyltransferasementioning

confidence: 99%

Involvement ofArabidopsis HACfamily genes in pleiotropic developmental processes

et al. 2014

Plant Signaling & Behavior

View full text Add to dashboard Cite

W ith intrinsic acetyltransferaseactivities, CREB binding protein (CBP)/p300 proteins mediate a variety of physiological events, such as proliferation, differentiation, and apoptosis, by regulating both histones and non-histone proteins. Arabidopsis CBP-type histone acetyltransferase family proteins, HACs, have been found to influence flower by regulating the expression of Flowering Locus C. We recently reported that HAC family genes involved in the ethylene signaling pathway. Thereafter, we systematically analyzed the morphological and developmental phenotypes of all the hac mutant combinations including plant size, root, flower, leaf defects, and late-flowering. Here we reinforce the ubiquitous regulation mechanism of HAC family genes, in which HAC1 plays a dominant role with the synergistic assist of HAC5 and HAC12, whereas HAC4 slightly alleviates the influence of HAC1 and HAC5.In mammals, CBP and p300 are very versatile proteins with intrinsic acetyltransferase activities, which participate in almost all processes of cell biology and organism development. [1][2][3] On the one hand, CBP/p300 modifies histones by acetylating the lysines in their N-terminal tails, whereby relaxes the chromatin structure and make chromosomal DNA more accessible to the transcription complex. 4 On the other hand, structural and functional studies have shown that CBP/p300 regulates many nonhistone proteins as well, including the important transcription factors, p53 and MEF2. [5][6][7] Both in vitro and in vivo data showed that CBP/p300 acetylates multiple lysine sites in the carboxyl terminus of the p53, which is indispensable for the p53-mediated transcription of p21. 7 Upon DNA damage, the CBP/p300 mediated acetylation of the p53 is greatly enhanced, which led to the stabilization of p53. 8 With a broad spectrum of CBP/ p300s functions, the studies on the HAC family genes in plants just show up a tip of the iceberg. In Arabidopsis, there are 5 HAC family members, namely HAC1, HAC2, HAC4, HAC5, and HAC12. The HAT activity of HAC1 was confirmed, whereas HAC2 was proved to lack of the HAT activity. Therefore, our studies were generated in terms of HAC1, HAC4, HAC5, and HAC12. There were 2 reports demonstrated that the HAC family genes promote flower by regulating the expression of the FLC. 9,10 Concurrently with the 2 groups, we found that hac1-involved mutants were significantly lateflowering compared with the WT plant. We measured the flowering time of all the hac mutant combinations grown under the long day condition (16h light/8h dark). We used the rosette leaf number, first flower bud appear time and first flower open time as the standards. The results were consistent for the 3 sets of data, following the sequence as WT (11.1 ± 1 RL), non-hac1-involved mutants (about 12

show abstract

Role of plant CBP/p300‐like genes in the regulation of flowering time

Cited by 88 publications

References 61 publications

The ArabidopsisGRF-INTERACTING FACTORGene Family Performs an Overlapping Function in Determining Organ Size as Well as Multiple Developmental Properties

The ArabidopsisGRF-INTERACTING FACTORGene Family Performs an Overlapping Function in Determining Organ Size as Well as Multiple Developmental Properties

Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci

Involvement ofArabidopsis HACfamily genes in pleiotropic developmental processes

Contact Info

Product

Resources

About