Role of Physical Activity and Cardiac Rehabilitation in Patients Undergoing Hematopoietic Stem Cell Transplantation

Mohananey, Divyanshu; Sarau, Alexandra; Kumar, Rohit; Lewandowski, David; Abreu-Sosa, Sol M.; Nathan, Sunita; Okwuosa, Tochukwu

doi:10.1016/j.jaccao.2021.01.008

Cited by 25 publications

(16 citation statements)

References 96 publications

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“…Связано это с пространственными ограничениями изоляционного бокса, большую часть которого занимают предметы первой необходимости, мебель и кровать [1]. В ряде исследований отмечена необходимость предтрансплантационной подготовки пациентов в целях профилактики развития двигательных осложнений после ТГСК [2][3][4], а также роль кардиореабилитации в посттранcплантационном периоде [5,6] и влияние физических нагрузок на разных этапах проведения ТГСК [7,8].…”

Section: онтогенетически обусловленная вертикализация детей и подрост...unclassified

The practice of ontogenetically determined movements of standing up among children and adolescents at the Department of Hematopoietic Stem Cell Transplantation as a preventive measure for orthostatic hypotension

Zhukov

Митраков

Laysheva

2022

Voprosy gematologii/onkologii i immunopatologii v pediatrii

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Hematopoietic stem cell transplantation (HSCT) requires a long hospitalization during which patients have to stay in transplantation wards, mainly in their single isolation rooms. One of the main goals of rehabilitation for HSCT patients is to prevent physical activity deficit by the introduction of an appropriate exercise programme and the monitoring of exercise adherence. The aim of our study was to evaluate the effectiveness of the prescribed exercise programme based on basic locomotor patterns to prevent physical activity deficit. The interim results of the prospective randomized controlled study included data from 20 patients. The study was approved by the Independent Ethics Committee and the Scientific Council of the 1Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation. An experimental group included 11 patients aged 8–16 years old (the median age was 12 years old); a control group included 9 patients aged 5–11 years old (the median age was 8 years old). Patients from the experimental group were preliminarily taught a set of exercises aimed at practicing ontogenically determined standing up which they should further perform during a day in their isolation rooms. The control group patients received recommendations on how to maintain physical activity in their isolation rooms. Their physical activity during a day was then monitored by the researchers. All study subjects underwent an orthoclinostatic test (i.e., transition from lying to standing and back) for the evaluation of the autonomic nervous system function on Day 1 of pre-transplant conditioning therapy and at the time of discharge from the HSCT Department. During the entire stay at the HSCT Department, the patients from both groups were daily assessed using the ADL (activities of daily living) scale. At the time of discharge from the HSCT Department, the experimental group patients showed more adaptive autonomic nervous system responses than the control group patients. Our interim analysis showed that the patients from the experimental group had higher scores of activities of daily living than the control patients. Orthoclinostatic test results confirmed that patients undergoing HSCT for acute leukemia were predisposed to develop maladaptive conditions or even orthostatic hypotension. A set of exercises including those for the training of ontogenetically determined process of standing up was shown to be an effective tool for the prevention of insufficient autonomic nervous system responses. Even a short (30 min) face-to-face session with a physical therapist significantly increased a patient's daily physical activity.

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Section: онтогенетически обусловленная вертикализация детей и подрост...unclassified

The practice of ontogenetically determined movements of standing up among children and adolescents at the Department of Hematopoietic Stem Cell Transplantation as a preventive measure for orthostatic hypotension

Zhukov

Митраков

Laysheva

2022

Voprosy gematologii/onkologii i immunopatologii v pediatrii

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“…Side effects of the CNIs are damage to the vessel endothelia, which leads to hypertension, and vascular diseases of the heart and brain. These impairments should be diagnosed and handled again mainly through exercise during follow-up care [ 61 ].…”

Section: Rehabilitation With Chronic Gvhdmentioning

confidence: 99%

Rehabilitation after Allogeneic Haematopoietic Stem Cell Transplantation: A Special Challenge

Bertz

2021

Cancers

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The general population is getting older and suffer more haematological malignancies despite being physically fit. These malignancies are mainly only curable via an alloHCT, and they are now carried out more frequently. Patients benefit from intensive rehabilitation earlier and may need it repeatedly in cases of severe side effects (e.g., graft-versus-host disease). They can suffer many problems that other cancer patients do not experience, such as severe infections, continued immunosuppression, nutritional restrictions, acute or chronic GvHD, or organ impairments (e.g., lung, eyes). They may also encounter various associated psychological problems, e.g., feeling like a chimera. Rehabilitation centres willing to care for patients after alloHCT should have an experienced multidisciplinary team and should work in close co-operation with the primary transplant centre.

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“…Post-hospitalization, GvHD symptoms, blood count fluctuations, or even psychosocial factors may affect the feasibility of rehabilitative interventions. Researchers have long been aware of the importance of the feasibility of rehabilitative interventions among allogeneic HSCT patients [ 9 ] and they argue that feasibility and safety should be assessed prior to the development of rehabilitative programs [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

A Scoping Review on Outcomes and Outcome Measurement Instruments in Rehabilitative Interventions for Patients with Haematological Malignancies Treated with Allogeneic Stem Cell Transplantation

et al. 2022

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Rationale: Allogeneic hematopoietic stem cell transplantation (HSCT) is associated with increased treatment-related mortality, loss of physical vitality, and impaired quality of life. Future research will investigate the effects of multidisciplinary rehabilitative interventions in alleviating these problems. Nevertheless, published studies in this field show considerable heterogeneity in selected outcomes and the outcome measurement instruments used. The purpose of this scoping review is to provide an overview of the outcomes and outcome measurement instruments used in studies examining the effects of rehabilitative interventions for patients treated with allogeneic HSCT. Methods: We conducted a scoping review that included randomized controlled trials, pilot studies, and feasibility studies published up to 28 February 2022. Results: We included n= 39 studies, in which n = 84 different outcomes were used 227 times and n = 125 different instruments were used for the measurements. Conclusions: Research in the field of rehabilitation for patients with haematological malignancies treated with allogeneic HSCT is hampered by the excess outcomes used, the inconsistent outcome terminology, and the inconsistent use of measurement instruments in terms of setting and timing. Researchers in this field should reach a consensus with regard to the use of a common terminology for the outcomes of interest and a homogeneity when selecting measurement instruments and measurement timing methods.

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Role of Physical Activity and Cardiac Rehabilitation in Patients Undergoing Hematopoietic Stem Cell Transplantation

Cited by 25 publications

References 96 publications

The practice of ontogenetically determined movements of standing up among children and adolescents at the Department of Hematopoietic Stem Cell Transplantation as a preventive measure for orthostatic hypotension

The practice of ontogenetically determined movements of standing up among children and adolescents at the Department of Hematopoietic Stem Cell Transplantation as a preventive measure for orthostatic hypotension

Rehabilitation after Allogeneic Haematopoietic Stem Cell Transplantation: A Special Challenge

A Scoping Review on Outcomes and Outcome Measurement Instruments in Rehabilitative Interventions for Patients with Haematological Malignancies Treated with Allogeneic Stem Cell Transplantation

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