Role of phospholipids in destabilization of lysosomal membranes in chronic alcohol poisoning

Tadevosyan, Yu. V.; Karagezyan, K. G.; Gevorkyan, G. A.; Batikyan, T. B.

doi:10.1007/bf00836148

Cited by 1 publication

(1 citation statement)

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“…Con A clearly fulfills this criterion with its multitude of triggered responses, e.g. in lymphoid cells an enhancement of mobility of phosphatidylcholine chains [18]and their deacylation [19]as well as the oxidation of sulfhydryl groups localized on the surface of the cell membrane [20]. As attested by this study, the application of target‐selective inhibitors is conducive to delineating the contribution of individual signaling pathways to the measurable parameter, i.e.…”

Section: Resultsmentioning

confidence: 76%

Differential potency of two crosslinking plant lectins to induce formation of haptenic‐sugar‐resistant aggregates of rat thymocytes by post‐binding signaling

Timoshenko

Gorudko

et al. 1999

FEBS Letters

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To evaluate the significance of post-binding events for stable aggregate formation, the aggregation/dissociation of rat thymocytes initiated by two crosslinking plant lectins, namely concanavalin A (Con A) and Solanum tuberosum agglutinin (STA), were comparatively studied. Despite intimate cell contacts in the aggregates only Con A led to establishment of haptenic-sugar-resistant (HSR) complexes. The presence of inhibitor II of diacylglycerol kinase, a dual calmodulin antagonist/protein kinase C inhibitor (trifluoperazine), and a sulfhydryl group reagent (N-ethylmaleimide) impaired this process. The obtained results indicate that the formation of HSR cellular contacts is not an automatic response to lectindependent cell association. In contrast to STA, Con A binding elicits this reaction with involvement of diacylglycerol kinase, protein kinase C and/or calmodulin as well as thiol level perturbation, as inferred by the application of target-selective inhibitors.z 1999 Federation of European Biochemical Societies.

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Section: Resultsmentioning

confidence: 76%