Role of phospholipase A in multiorgan failure with special reference to ARDS and acute renal failure (ARF)

Baur, Michael; Schmid, T.; Landauer, B

doi:10.1007/bf01711353

Cited by 31 publications

(10 citation statements)

References 5 publications

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“…Acute pancreatitis is an autodigestive disease in which digestive enzymes synthesized in the pancreatic acinar cells destroy the gland. Schmidt and Creutzfeldt came to the conclusion that pancreatic PLA 2 might be responsible for the glandular and periglandular tissue necrosis (12,13). These findings have been confirmed by others (14,15).…”

Section: Discussionmentioning

confidence: 59%

Pancreatic Phospholipase A2 Activity in Acute Pancreatitis: a Prognostic Marker for Early Identification of Patients at Risk

Aufenanger

Samman²,

Quintel³

et al. 2002

Clinical Chemistry and Laboratory Medicine

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Remarkably elevated levels of phospholipase A 2 (PLA 2 ) are measurable in human blood samples in cases of acute pancreatitis. The source of the enzyme was first thought to be exclusively the pancreas, but now it is generally accepted that two isoenzymes − the pancreatic PLA 2 , group I, and the extrapancreatic PLA 2 , group II − contribute to the raised activity. In contrast to the group II-PLA 2 , the pancreatic PLA 2 is heat-resistant for 1 hour at 60 °C. The catalytically inactive proenzyme of the pancreatic PLA 2 can be activated by trypsin. The aim of our study was to evaluate the diagnostic value of PLA 2 isoenzyme activity measurements to identify patients with severe complications in acute pancreatitis. Blood samples from patients suffering from acute pancreatitis were analyzed for catalytically active pancreatic PLA 2 on day 1 and 2 of hospitalization with a modified radiometric Escherichia coli-based PLA 2 assay. In 10 of 41 patients clearly elevated values of catalytically active, heat-resistant pancreatic PLA 2 (7.2 to 81.2 U/l) were observed. This group of patients was characterized by severe complications (necrotizing pancreatitis, shock, sepsis, respiratory problems) of which two patients subsequently died. Patients with low or undetectable activity (<7 U/l) of pancreatic PLA 2 recovered rapidly. According to these results the presence of catalytically active pancreatic PLA 2 in serum is associated with severe complications of acute pancreatitis. In contrast to total serum-PLA 2 , the catalytic concentration of pancreatic PLA 2 can serve as a prognostic marker in acute pancreatitis. Clin Chem Lab Med 2002; 40(3):293-297

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Section: Discussionmentioning

confidence: 59%

Pancreatic Phospholipase A2 Activity in Acute Pancreatitis: a Prognostic Marker for Early Identification of Patients at Risk

Aufenanger

Samman²,

Quintel³

et al. 2002

Clinical Chemistry and Laboratory Medicine

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“…As such, prompt introduction of antibiotics should only be considered in the relevant patient groups and this precludes unnecessary use of antibiotics which gives rise to antimicrobial resistance. Apart from that, the degree of elevation of serum sPLA2-IIA was found to correlate with the severity of sepsis and may prove to be useful in predicting its outcomes [44, 45]. Patients who developed septic shock had been shown to depict higher levels of sPLA2-IIA than those who did not [46].…”

Section: Discussionmentioning

confidence: 99%

The role of group IIA secretory phospholipase A2 (sPLA2-IIA) as a biomarker for the diagnosis of sepsis and bacterial infection in adults—A systematic review

Tan

Goh

2017

PLoS ONE

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IntroductionThis paper investigates the role of Group II Secretory Phospholipase A2 (sPLA2-IIA) as a biomarker for the diagnosis of sepsis and bacterial infection in adults. Sepsis and bacterial infection are common problems encountered by patients in the hospital and often carry adverse outcomes if not managed early.MethodsTwo independent reviewers conducted a comprehensive search using Ovid MEDLINE published from years 1993 to 2016 and SCOPUS published from year 1985 to 2017 to screen for relevant studies. The main inclusion criteria included adult subjects, patients with suspected or confirmed signs of infection and relevant outcomes which looked into the role of sPLA2-IIA in detecting the presence of sepsis and bacterial infection in the subjects.Results and discussionFour studies met the inclusion criteria. SPLA2-IIA was found to be effective in detecting the presence of sepsis and bacterial infection in adults. The levels of serum sPLA2-IIA also correlated well with the presence of sepsis and bacterial infection.ConclusionThis systematic review highlights the role of sPLA2-IIA as a reliable tool to diagnose sepsis and bacterial infection in adult patients. Nonetheless, further studies should be done in the future to provide more compelling evidence on its application in the clinical setting.

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“…Alveolar ventilation and perfusion and gas exchange should be checked in the future studies. PLA, is known to produce arachidonic acid and lysophospholipid, which are widely involved in the production of potent inflammatory mediators such as prostaglandins, leukotrienes, and platelet-activating factor (PAF) (22)(23)(24)(25)(26). These products have a crucial role in the exacerbation of systemic complications such as shock, sepsis, or multiple organ failure (MOF).…”

Section: Discussionmentioning

confidence: 99%

Effect of New Inhibitor of Type II Phospholipase A2 on Experimental Acute Pancreatitis in Rats

Yoshikawa¹,

Naruse²,

Kitagawa³

et al. 1999

Pancreas

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The catalytic activity of type I1 phospholipase A, (PLA,) in blood has been reported to increase in acute pancreatitis and to reflect the severity of pancreatitis. In this study, we evaluated the effects of a new inhibitor of type I1 PLA,, S5920/ LY3 15920Na, on trypsin-taurocholate-induced pancreatitis in rats. Hemorrhagic pancreatitis was induced by an infusion of a mixture of trypsin and taurocholate into the pancreatic duct. S5920LY3 15920Na was administered subcutaneously at 0 h and 3 h after the induction of pancreatitis. Survival rates for 24 h in rats treated with 0.1 and 1 mg/kg of S5920/ LY3 15920Na were significantly higher than that in untreated rats (71 and 86% vs. 14%). Serum levels of amylase and lipase in rats treated with 1 mgkg of S5920ILY315920Na were significantly lower than those in untreated rats (amylase, 6,903 vs. 32,516 U L ; and lipase, 514 vs. 6,710 U L ) at the time of death or 24 h after the induction of pancreatitis. Plasma levels of S5920LY3 15920Na were enough to inhibit catalytic activity of PLA, in plasma for 9 h. A new inhibitor of type I1 PLA,, S5920LY3 15920Na, inhibited catalytic activity of PLA, and improved the survival rate in experimental hemorrhagic pancreatitis in rats.

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Role of phospholipase A in multiorgan failure with special reference to ARDS and acute renal failure (ARF)

Cited by 31 publications

References 5 publications

Pancreatic Phospholipase A2 Activity in Acute Pancreatitis: a Prognostic Marker for Early Identification of Patients at Risk

Pancreatic Phospholipase A2 Activity in Acute Pancreatitis: a Prognostic Marker for Early Identification of Patients at Risk

The role of group IIA secretory phospholipase A2 (sPLA2-IIA) as a biomarker for the diagnosis of sepsis and bacterial infection in adults—A systematic review

Effect of New Inhibitor of Type II Phospholipase A2 on Experimental Acute Pancreatitis in Rats

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