Role of phIGFBP-1 and ultrasound cervical length in predicting pre-term labour

Azlin, M I Nor; Bang, Heejin; An, Leathem; Mohamad, Saeed; Mansor, N. A.; Yee, B. See; Zulkifli, N. H.; Tamil, Azmi Mohd

doi:10.3109/01443615.2010.489162

Cited by 12 publications

(10 citation statements)

References 16 publications

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“…45,48,55,58,60,61,68 Twelve studies (35%) did not include cervical changes in the diagnosis of preterm labor; 17,46,50,51,59,65,66,72-76 ; one study included women with or without cervical changes; 18 and 14 studies did not report clearly on the definition of preterm labor. 47,49,52-54,56,57,62-64,67,69-71 All studies were limited to women with intact membranes. Two studies included exclusively twin gestations, both in asymptomatic women.…”

Section: Resultsmentioning

confidence: 99%

Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis

Conde-Agudelo

Romero

2016

American Journal of Obstetrics and Gynecology

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OBJECTIVE To assess the accuracy of the cervical phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) test to predict preterm birth in women with and without symptoms of preterm labor through use of formal methods for systematic reviews and meta-analytic techniques. DATA SOURCES PubMed, Embase, Cinahl, Lilacs, and Medion (all from inception to June 20, 2015), reference lists, conference proceedings, and Google scholar. STUDY ELIGIBILITY CRITERIA Cohort or cross-sectional studies that reported on the predictive accuracy of cervical phIGFBP-1 test for preterm birth. STUDY APPRAISAL AND SYNTHESIS METHODS Two reviewers independently selected studies, assessed risk of bias, and extracted data. Summary receiver operating characteristic curves, pooled sensitivities and specificities, and summary likelihood ratios were generated. RESULTS Forty-three studies met the inclusion criteria of which 15 provided data on asymptomatic women (n=6583) and 34 on women with an episode of preterm labor (N=3620). Among asymptomatic women, the predictive accuracy of cervical phIGFBP-1 test for preterm birth at <37, <34 and <32 weeks of gestation was minimal with pooled sensitivities and specificities, and summary positive and negative likelihood ratios ranging from 14-47%, 76-93%, 1.5-4.4, and 0.6-1.0, respectively. Among women with an episode of preterm labor, the test had a low predictive performance for delivery within 7 and 14 days of testing, and preterm birth at <34 and <37 weeks of gestation with pooled sensitivities and specificities, and summary positive and negative likelihood ratios that varied between 60 and 68%, 77 and 81%, 2.7 and 3.5, and 0.4 and 0.5, respectively. A negative test result in women with an episode of preterm labor had a low to moderate accuracy to identify women who are not at risk for delivering within the next 48 hours (summary negative likelihood ratio of 0.28 in all women and 0.23 in women with singleton gestations). CONCLUSION Cervical phIGFBP-1 has potential utility to identify patients with an episode of preterm labor who will not deliver within 48 hours. However, its overall predictive ability for the identification of symptomatic and asymptomatic women at risk for preterm birth is limited.

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Section: Resultsmentioning

confidence: 99%

Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis

Conde-Agudelo

Romero

2016

American Journal of Obstetrics and Gynecology

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“…In addition, detection of vaginal infections such as BV, trichomoniasis, candida, or Chlamydia trachomatis during the current pregnancy, cervical length as measured at the first recorded ultrasound, and treatment with drugs for preterm labor were evaluated during the medical chart review. All variables were included in the analysis to assess for confounding because prior studies have indicated that these factors have been related to the occurrence of preterm birth …”

Section: Methodsmentioning

confidence: 99%

“…All variables were included in the analysis to assess for confounding because prior studies have indicated that these factors have been related to the occurrence of preterm birth. [16][17][18][19] Risk Factor of Interest…”

Section: Potential Confoundersmentioning

confidence: 99%

Role of Perceived Stress in the Occurrence of Preterm Labor and Preterm Birth Among Urban Women

Seravalli¹,

Patterson²,

Nelson³

2014

J Midwife Womens Health

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Introduction This study examined whether prenatal perceived stress levels during pregnancy were associated with preterm labor (PTL) or preterm birth (PTB). Methods Perceived stress levels were measured at 16 weeks gestation or less and between 20 and 24 weeks gestation in a sample of 1,069 low-income pregnant women attending Temple University prenatal care clinics. Scores were averaged to create a single measure of prenatal stress. PTB was defined as the occurrence of a spontaneous birth prior to 37 weeks gestation. PTL was defined as the occurrence of regular contractions between 20 and 37 weeks of pregnancy that were associated with changes in the cervix. Results Independent of potential confounding factors, prenatal perceived stress was not associated with PTL (OR 1.10; 95% CI 0.69-1.78, P = .66); however, prenatal stress trended toward an association with PTB (OR 1.49; 95% CI: 1.00-2.23, P =.05). The strongest predictor of preterm labor was a history of preterm labor in a prior pregnancy. Women with a history of PTL were two times more likely to experience PTL in the current pregnancy than women who did not have a PTL history (OR 2.16; 95% CI 1.05-4.41, P =.04). Historical risk factors of PTB, such as African American race, a history of abortion or a history of PTB were not related to PTL. The strongest predictor of PTB was having a history of PTB in a prior pregnancy (OR 2.55; 95% CI 1.54-4.24, P <.001). Discussion Prenatal perceived stress levels may be a risk factor for PTB independent of PTL; however, prenatal stress was not associated with PTL. Risk factors for PTL may be different from those of PTB.

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“…Overall, 14 studies (n = 2278 women) 15,17,20,21,30,40-48 reporting on PAMG-1, 40 (n = 7431 women) 14,15,18,20,22,28,29,[40][41][42] on fFN and 22 (n = 3192 women) 16,18,19,28,30,48,54,73,[79][80][81][82][83][84][85][86][87][88][89][90][91][92] on phIGFBP-1 were included in the final analysis. Of these, 11 studies included performance metrics for more than one biomarker.…”

Section: Study Characteristics and Risk Of Biasmentioning

confidence: 99%

Prediction of preterm delivery in symptomatic women using PAMG‐1, fetal fibronectin and phIGFBP‐1 tests: systematic review and meta‐analysis

Melchor

Khalil

Wing

et al. 2018

Ultrasound in Obstet & Gyne

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In the prediction of sPTB within 7 days of testing in women with signs and symptoms of preterm labor, the PPV of PAMG-1 was significantly higher than that of phIGFBP-1 or fFN. Other diagnostic accuracy measures did not differ between the three biomarker tests. As prevalence affects the predictive performance of a diagnostic test, use of a highly specific assay for a lower-prevalence syndrome such as sPTB may optimize management. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

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Role of phIGFBP-1 and ultrasound cervical length in predicting pre-term labour

Cited by 12 publications

References 16 publications

Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis

Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis

Role of Perceived Stress in the Occurrence of Preterm Labor and Preterm Birth Among Urban Women

Prediction of preterm delivery in symptomatic women using PAMG‐1, fetal fibronectin and phIGFBP‐1 tests: systematic review and meta‐analysis

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