Role of Phenylethanolamine‐N‐methyltransferase on Nicotine‐Induced Vasodilation in Rat Cerebral Arteries
Ming‐Wei Li,
Shang‐Jen Chang,
Hsi‐Hsien Chang
et al.
Abstract:ObjectiveThe sympathetic–parasympathetic (or axo–axonal) interaction mechanism mediated that neurogenic relaxation, which was dependent on norepinephrine (NE) releases from sympathetic nerve terminal and acts on β2‐adrenoceptor of parasympathetic nerve terminal, has been reported. As NE is a weak β2‐adrenoceptor agonist, there is a possibility that synaptic NE is converted to epinephrine by phenylethanolamine‐N‐methyltransferase (PNMT) and then acts on the β2‐adrenoceptors to induce neurogenic vasodilation.Met… Show more
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