“…15,16 The 1-Cys PRDX contains only the peroxidatic cysteine, and not a resolving cysteine. 16 Based on the presence of one conserved redox-active cysteine in the NH2 terminus of PRDX6 (C-47), previously known as antioxidant protein 2 (AOP2) 2,3,[17][18][19][20] in contrast to two conserved cysteine residues in the rest of the PRDX family, the Mouse Genomic Nomenclature Committee (MGNC) and Human Gene Nomenclature Committee (HGNC) put this molecule under subgroup 6, now known as PRDX6. 12 H 2 O 2 , a source of oxidative stress, has gained attention recently due to its role as a cellular signaling factor for various cytokines and growth factors, including platelet-derived growth factor (PDGF), insulin-like growth factor (IGF), endothelial-derived growth factor (EGF), tumor necrosis factor a (TNF-a), and transforming growth factor b (TGFb).…”