Biochemical Pharmacology volume 82, issue 3, P269-277 2011 DOI: 10.1016/j.bcp.2011.04.015 View full text
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Mariane A. Silva, Jonatas Z. Klafke, Mateus F. Rossato, Camila Gewehr, Gustavo P. Guerra, Maribel A. Rubin, Juliano Ferreira

Abstract: Polyamines (putrescine, spermidine and spermine) are aliphatic amines that are produced by the action of ornithine decarboxylase (ODC) in a rate-limiting and protein kinase C (PKC)-regulated step. Because high levels of polyamines are found in the synovial fluid of arthritic patients, the aim of the present study was to identify the role of peripherally produced polyamines in a model of inflammatory pain induced by adjuvant. The subcutaneous injection of Complete Freund's adjuvant (CFA, 50 μL/paw) caused the d…

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