Role of peripheral blood lymphocytes in experimental allergic (Pertussis) encephalomyelitis

Kanchurin, A. Kh.; Babakhin, A A; Gervazieva, Valentina

doi:10.1007/bf00796663

Cited by 1 publication

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“…EAE changes can be obtained in guinea pigs with pertussis vaccine even in the absence of immunization with CNS antigen [5,6]. In most studies, however, pertus sis vaccine has been used together with CNS antigen in Freund's adjuvant.…”

Section: Introductionmentioning

confidence: 99%

Effect of <i>Bordetella pertussis</i> Vaccine on Experimental Autoimmune Encephalomyelitis in Rats

Källén¹,

Nilsson²

1986

Int Arch Allergy Immunol

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Administration of Bordetella pertussis vaccine simultaneously with the immunization of rats with guinea pig encephalitogenic protein in Freund’s complete adjuvant results in the development of hyperacute encephalomyelitis in the Lewis strain, a strain which reacts with ordinary experimental autoimmune encephalomyelitis (EAE) when immunization is performed without pertussis vaccine. A marked augmentation of the EAE response was seen with pertussis vaccine in the Fischer and PVG strains, both low responders without pertussis, and relapsing EAE developed in some animals. Hyperacute EAE did not develop, however. No effect was seen on the resistant BN strain, but strong EAE developed in the otherwise low-susceptible F₁(BN × F) and the practically resistant F₂(BN × F) hybrids – in the latter hybrids, EAE developed only when Ir-EAE genes linked to AgB 1 were present. In the F₁ hybrids, pertussis vaccine could be given from 4 days before to 5 days after the immunization and an effect was still seen, although a maximal effect was seen when the vaccine was given at 0 or 2 days after immunization.

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Section: Introductionmentioning

confidence: 99%