Role of Periostin in Uncontrolled Asthma in Children (DADO study)

Abstract

Background: Asthma is the most common chronic disease in children. Cases of severe asthma (SA) are underdiagnosed. Periostin is a biomarker for SA in adults, but its role in children is poorly understood. Objectives: The aims of the study were to estimate the percentage of cases of uncontrolled severe asthma (UcSA) in children with poorly controlled asthma and to evaluate the role of periostin as a biomarker. Materials and Methods: We performed an observational study in children aged 5 to 14 years with poorly controlled asthma. Demographic and clinical data were collected in addition to the results of the lung function test, the fraction of exhaled nitric oxide, the skin prick test, total IgE, specific IgE, blood eosinophil count, serum periostin, treatment, asthma control, and quality of life. Variables were compared between the group with UcSA and the other children. Results: Fifty children with poorly controlled asthma (72% male) were included. Nineteen children (38%) had UcSA. Most children had limitations in their activities of daily living and had visited the emergency department. In addition, 38% were hospitalized. Quality of life was poor. Only 42% of the children received appropriate treatment. The UcSA group was more likely to have a total IgE >500 kU A /mL (52.6% vs 19%, P=.02) and less likely to have serum periostin >1000 ng/mL (31.2% vs 63%, P=.04). Conclusions: In our setting, 38% of children with poorly controlled asthma have UcSA, which is associated with higher levels of total serum IgE and lower levels of serum periostin.

Cytokines in the Respiratory Airway as Biomarkers of Severity and Prognosis for Respiratory Syncytial Virus Infection: An Update

“…Lopez-Guisa and colleagues evaluated periostin levels in bronchial and nasal cells from asthmatic, non-asthmatic, atopic, and healthy children and found a significant increase in periostin levels in asthmatic children (3.7 times), as compared to the other groups (96). These results were confirmed in studies that showed a correlation between high levels of periostin in the serum with persistent or uncontrolled asthma in children (97, 98). In fact, clinical manifestations of asthma are considered to be very similar to bronchiolitis symptoms (123).…”

Can serum periostin, YKL‐40, and osteopontin levels in pre‐school children with recurrent wheezing predict later development of asthma?

“…Therefore, it is considered that determining the level of serum periostin in children aged ≥ 6 years may be helpful in the diagnosis of asthma. Conversely, Habernau Menaet al 21 have shown that children with severe uncontrolled asthma have lower periostin levels than children with severe controlled asthma. Therefore, it is unclear whether periostin measurements in developing children with asthma are useful.…”

Biomarkers in inflammometry pediatric asthma: utility in daily clinical practice

“…They studied 28 children with controlled persistent asthma and 27 healthy children (6–16 years) and assessed utility of serum periostin levels in diagnosing pediatric asthma, as they detected periostin values equivalent to conventional biomarkers, confirming the utility of serum periostin levels in diagnosing asthma in children. [ 73 ] Habernau et al [ 74 ] measured serum periostin in a group of children (5–14 years old) with uncontrolled asthma and without correct treatment, and they found higher periostin levels (average 900 ng dl –1 ) compared to previous studies published in children with controlled asthma and with adequate treatment following clinical guidelines.…”