Role of perfusion-weighted imaging at 3 Tesla in the assessment of malignancy of cerebral gliomas

Costanzo, Alfonso Di; Pollice, Saverio; Trojsi, Francesca; Giannatempo, G.M.; Popolizio, Teresa; Canalis, L.; Armillotta, Matteo; Maggialetti, A.; Carriero, Alessandro; Tedeschi, G.; Scarabino, Tommaso

doi:10.1007/s11547-008-0232-2

Cited by 27 publications

(14 citation statements)

References 21 publications

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“…Previous studies have reported that both dynamic susceptibility contrast-PWI and arterial spin-labeling PWI can distinguish histologic grades of gliomas. 29,30 However, PWI had limited usefulness in the differentiation of subgroups of oligodendrogliomas with considerable overlap in rCBV max and maximal cerebral blood flow between low and high grades. 21,29,31 One study reported specific genotypic differences in oligodendrogliomas by use of dynamic susceptibility contrast-PWI, 11 with significantly higher rCBV max in only low-grade oligodendrogliomas with 1p/ 19q LOH.…”

Section: Discussionmentioning

confidence: 99%

Differentiation between Oligodendroglioma Genotypes Using Dynamic Susceptibility Contrast Perfusion-Weighted Imaging and Proton MR Spectroscopy

Chawla¹,

Krejza²,

Vossough³

et al. 2013

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

Differentiation between Oligodendroglioma Genotypes Using Dynamic Susceptibility Contrast Perfusion-Weighted Imaging and Proton MR Spectroscopy

Chawla¹,

Krejza²,

Vossough³

et al. 2013

AJNR Am J Neuroradiol

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“…Recently, the lenticulostriate arteries were visualised by 7 T MR angiography in vivo, and the depiction of microvasculature as small as 100 µm was achieved by ultrahigh-field MR systems [5,18]. At 1.5 T and 3 T other important MR techniques for the evaluation of tissue vascularity like perfusion MRI and dynamic susceptibility contrast-enhanced MRI measure the increased cerebral blood flow and blood volume in tumour areas, but with limited morphological information compared with T2*-w images [19,20]. Neither technique is currently established for 7 T MRI.…”

Section: Discussionmentioning

confidence: 99%

Imaging of adult astrocytic brain tumours with 7 T MRI: preliminary results

et al. 2009

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“…For intracranial tumors, 3.0 T scanners have shown better SNR, spatial and temporal resolution, contrast-to-noise ratio, and spectral resolution than 1.5 T scanners with the same acquisition parameters [76][77][78][79] . However, the applications in other regions of the body, the added value of 3.0 T compared with 1.5 T scanners is still controversial, due to issues such as specific absorption rate and motion and susceptibility artifacts.…”

Section: Clinical and High-field-strength Mri Scannersmentioning

confidence: 99%

Multiparametric MRI biomarkers for measuring vascular disrupting effect on cancer

Marchal¹,

2011

WJR

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Solid malignancies have to develop their own blood supply for their aggressive growth and metastasis; a process known as tumor angiogenesis. Angiogenesis is largely involved in tumor survival, progression and spread, which are known to be significantly attributed to treatment failures. Over the past decades, efforts have been made to understand the difference between normal and tumor vessels. It has been demonstrated that tumor vasculature is structurally immature with chaotic and leaky phenotypes, which provides opportunities for developing novel anticancer strategies. Targeting tumor vasculature is not only a unique therapeutic intervention to starve neoplastic cells, but also enhances the efficacy of conventional cancer treatments. Vascular disrupting agents (VDAs) have been developed to disrupt the already existing neovasculature in actively growing tumors, cause catastrophic vascular shutdown within short time, and induce secondary tumor necrosis. VDAs are cytostatic; they can only inhibit tumor growth, but not eradicate the tumor. This novel drug mechanism has urged us to develop multiparametric imaging biomarkers to monitor early hemodynamic alterations, cellular dysfunctions and metabolic impairments before tumor dimensional changes can be detected. In this article, we review the characteristics of tumor vessels, tubulindestabilizing mechanisms of VDAs, and in vivo effects of the VDAs that have been mostly studied in preclinical studies and clinical trials. We also compare the different tumor models adopted in the preclinical studies on VDAs. Multiparametric imaging biomarkers, mainly diffusion-weighted imaging and dynamic contrast-enhanced imaging from magnetic resonance imaging, are evaluated for their potential as morphological and functional imaging biomarkers for monitoring therapeutic effects of VDAs.

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Role of perfusion-weighted imaging at 3 Tesla in the assessment of malignancy of cerebral gliomas

Abstract: Three-Tesla PWI helps to distinguish necrosis from tumour mass, infiltrating tumour from oedema and high-grade from low-grade gliomas. It enhances the magnetic resonance (MR) assessment of cerebral gliomas and provides useful information for planning surgical and radiation treatment.

Cited by 27 publications

References 21 publications

Differentiation between Oligodendroglioma Genotypes Using Dynamic Susceptibility Contrast Perfusion-Weighted Imaging and Proton MR Spectroscopy

Differentiation between Oligodendroglioma Genotypes Using Dynamic Susceptibility Contrast Perfusion-Weighted Imaging and Proton MR Spectroscopy

Imaging of adult astrocytic brain tumours with 7 T MRI: preliminary results

Multiparametric MRI biomarkers for measuring vascular disrupting effect on cancer

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