Role of particle shape on efficient and organ-based drug delivery

Nejati, Sara; Vadeghani, Elham Mohseni; Khorshidi, Sajedeh; Karkhaneh, Akbar

doi:10.1016/j.eurpolymj.2019.109353

Cited by 46 publications

(34 citation statements)

References 113 publications

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“…Previous analysis shows that PsEUL-OVA has a relatively large molecular weight. Studies have confirmed that the size of the drug is related to its systemic bioavailability [ 49 ]. Therefore, it is important to understand the particle size and stability of the PsEUL-OVA in the liquid.…”

Section: Resultsmentioning

confidence: 99%

Eucommia ulmoides Leaf Polysaccharide in Conjugation with Ovalbumin Act as Delivery System Can Improve Immune Response

et al. 2021

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In this investigation, to maximize the desired immunoenhancement effects of PsEUL and stimulate an efficient humoral and cellular immune response against an antigen, PsEUL and the model antigen ovalbumin (OVA) were coupled using the N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC) reaction to yield a novel delivery system (PsEUL-OVA). The physicochemical characteristics and immune regulation effects of this new system were investigated. We found the yield of this EDC method to be 46.25%. In vitro, PsEUL-OVA (200 μg mL−1) could enhance macrophage proliferation and increase their phagocytic efficiency. In vivo, PsEUL-OVA could significantly increase the levels of OVA-specific antibody (IgG, IgG1, IgG2a, and IgG2b) titers and cytokine (IL-2, IL-4, IL-6, IFN-γ) levels. Additionally, it could activate T lymphocytes and facilitate the maturation of dendritic cells (DCs). These findings collectively suggested that PsEUL-OVA induced humoral and cellular immune responses by promoting the phagocytic activity of macrophages and DCs. Taken together, these results revealed that PsEUL-OVA had the potential to improve immune responses and provide a promising theoretical basis for the design of a novel delivery system.

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Section: Resultsmentioning

confidence: 99%

Eucommia ulmoides Leaf Polysaccharide in Conjugation with Ovalbumin Act as Delivery System Can Improve Immune Response

et al. 2021

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“…These physical properties can be controlled by the NP’s chosen synthesis method or design. A theoretical study suggested that the NP shape affects a particle’s circulation half-life in the blood [ 193 ]. This was supported in a study that showed that filamentous polymer micelles have long-circulating lifetimes (>one week) after administration, while spherical counterparts lasted for about 2 to 3 days [ 194 ].…”

Section: Potential Of Ferrites In Biomedical Applicationsmentioning

confidence: 99%

Advances in the Synthesis and Application of Magnetic Ferrite Nanoparticles for Cancer Therapy

et al. 2022

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Cancer is among the leading causes of mortality globally, with nearly 10 million deaths in 2020. The emergence of nanotechnology has revolutionised treatment strategies in medicine, with rigorous research focusing on designing multi-functional nanoparticles (NPs) that are biocompatible, non-toxic, and target-specific. Iron-oxide-based NPs have been successfully employed in theranostics as imaging agents and drug delivery vehicles for anti-cancer treatment. Substituted iron-oxides (MFe2O4) have emerged as potential nanocarriers due to their unique and attractive properties such as size and magnetic tunability, ease of synthesis, and manipulatable properties. Current research explores their potential use in hyperthermia and as drug delivery vehicles for cancer therapy. Significantly, there are considerations in applying iron-oxide-based NPs for enhanced biocompatibility, biodegradability, colloidal stability, lowered toxicity, and more efficient and targeted delivery. This review covers iron-oxide-based NPs in cancer therapy, focusing on recent research advances in the use of ferrites. Methods for the synthesis of cubic spinel ferrites and the requirements for their considerations as potential nanocarriers in cancer therapy are discussed. The review highlights surface modifications, where functionalisation with specific biomolecules can deliver better efficiency. Finally, the challenges and solutions for the use of ferrites in cancer therapy are summarised.

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“…In this respect, polymer coatings serve to stabilize the nanoparticles and increase their dispersion in blood circulation. [18,19] The impact of the shape of nanoparticles on their fate inside the body was shown, for example, by PEGylated gold nanospheres, which had a longer half-life in the blood stream, a lower clearance by the reticuloendothelial system, and a higher overall tumor uptake than the disk-, rod-or cage-shaped ones of the same size. [24] Besides modifying their surface, the functionality of polymer assemblies can be significantly enlarged through the incorporation of inorganic nanoparticles that endow the nanomaterials with multiple therapeutic and/or diagnostic functions.…”

Section: Introductionmentioning

confidence: 99%

Tailoring Polymer‐Based Nanoassemblies for Stimuli‐Responsive Theranostic Applications

Muthwill

Kong

Dinu

et al. 2022

Macromolecular Bioscience

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Polymer assemblies on the nanoscale represent a powerful toolbox for the design of theranostic systems when combined with both therapeutic compounds and diagnostic reporting ones. Here, recent advances in the design of theranostic systems for various diseases, containing—in their architecture—either polymers or polymer assemblies as one of the building blocks are presented. This review encompasses the general principles of polymer self‐assembly, from the production of adequate copolymers up to supramolecular assemblies with theranostic functionality. Such polymer nanoassemblies can be further tailored through the incorporation of inorganic nanoparticles to endow them with multifunctional therapeutic and/or diagnostic features. Systems that change their architecture or properties in the presence of stimuli are selected, as responsivity to changes in the environment is a key factor for enhancing efficiency. Such theranostic systems are based on the intrinsic properties of copolymers or one of the other components. In addition, systems with a more complex architecture, such as multicompartments, are presented. Selected systems indicate the advantages of such theranostic approaches and provide a basis for further developments in the field.

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Role of particle shape on efficient and organ-based drug delivery

Cited by 46 publications

References 113 publications

Eucommia ulmoides Leaf Polysaccharide in Conjugation with Ovalbumin Act as Delivery System Can Improve Immune Response

Eucommia ulmoides Leaf Polysaccharide in Conjugation with Ovalbumin Act as Delivery System Can Improve Immune Response

Advances in the Synthesis and Application of Magnetic Ferrite Nanoparticles for Cancer Therapy

Tailoring Polymer‐Based Nanoassemblies for Stimuli‐Responsive Theranostic Applications

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