Role of partial splenic arterial embolization for hypersplenism in patients with liver cirrhosis and thrombocytopenia

Abdella, Heba M.; Abdelmoez, Amal Tohamy; El-Maaty, Mohammed E. Abu; Helmy, Ali Z.

doi:10.1007/s12664-010-0013-4

Cited by 17 publications

(11 citation statements)

References 18 publications

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“…All patients developed post-embolization syndrome. Left-sided pleural effusion and increase in amount or developing new ascites occurred in six and five patients, respectively [13].…”

Section: Discussionmentioning

confidence: 94%

Resolution of Hypersplenism and Pancytopenia in Common Variable Immunodeficiency Patient After Partial Splenic Artery Embolization: A Case Report and Review of Literature

Sumayli¹,

Shekaili²,

Gazlan³

et al. 2015

J Hematol

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Common variable immunodeficiency (CVID) is the second most prevalent primary immunodeficiency disorder following selective immunoglobulin A (IgA) deficiency but it is more complicated clinically. It causes a wide spectrum of symptoms and signs affecting several systems of the body. CVID is mostly a humoral immunodeficiency with cell-mediated immunity being affected in some patients leading to both autoimmunity and malignancy adding to the immunodeficiency, which makes the management of these patients very complicated. Gastrointestinal tract (GIT) and bone marrow are commonly affected organs by both autoimmunity and malignancy in the context of CVID. In this paper, we present a case of CVID who presented with pancytopenia secondary to hypersplenism and failed both intravenous immunoglobulins (IVIG) and steroids treatment. She underwent partial splenic artery embolization as an alternative procedure to total splenectomy to preserve some splenic function and avoid surgical total splenectomy. Partial splenic artery embolization leads to dramatic improvement in platelets, hemoglobin and white cell count after the procedure without further compromising her immune system.

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“…All patients developed post-embolization syndrome. Left-sided pleural effusion and increase in amount or developing new ascites occurred in six and five patients, respectively [13].…”

Section: Discussionmentioning

confidence: 94%

Resolution of Hypersplenism and Pancytopenia in Common Variable Immunodeficiency Patient After Partial Splenic Artery Embolization: A Case Report and Review of Literature

Sumayli¹,

Shekaili²,

Gazlan³

et al. 2015

J Hematol

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“…Hematologic response correlates with the amount of the infarcted splenic tissue after partial splenic embolization. Almost all of the interventionists attempt to achieve infarction between 50% and 70% of the splenic mass to get good therapeutic hematologic response and alleviate hypersplenism [3].…”

Section: Introductionmentioning

confidence: 99%

Radiofrequency Ablation versus Partial Splenic Artery Embolization in Hypersplenism

Aboelezz¹,

Hemmat

Eladl³

et al. 2019

The Medical Journal of Cairo University

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Background: Radiofrequency Ablation (RFA) has undergone tremendous progress with the advances in modern technologies because of its minimal invasiveness, good tolerance, and rapid recovery more than Partial Splenic Artery embolization (PSE) in treatment of hypersplenism.Aim: The aim of the study was to correlate results from RFA and PSE with clinical and laboratory findings in patients with hypersplenism.

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“…Additionally, splenectomy can lead to serious emotional and neurological deterioration in WD patients [7]. Partial splenic embolization (PSE) has been widely used as an alternative to splenectomy for the treatment of hypersplenism because it is minimally invasive and associated with fewer complications [5,6,8,9].…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Hypersplenism in Wilson's Disease by Partial Splenic Embolization

Chen

Yuan-cheng

et al. 2017

Journal of Investigative Surgery

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Aim: Hypersplenism can occur in patients with Wilson's disease (WD). Surgical splenectomy is a conventional treatment for this condition; however, emotional and neurological deterioration may follow splenectomy. In recent years, partial splenic embolization (PSE) has been increasingly performed as a nonsurgical alternative treatment for hypersplenism. The aim of this study was to evaluate the effectiveness and safety of PSE compared with splenectomy in the treatment of hypersplenism in WD patients. Methods: Fifty WD patients with hypersplenism were randomly divided into two groups (group A and group B), each including 25 patients. Patients in groups A and B were treated with PSE and splenectomy, respectively. Data were collected on the clinical efficacy of each procedure, adverse reactions, hematologic and blood chemistry test results, and abdominal computed tomography (CT) scan findings (group A only). Results: Marked improvements in the platelet and leukocyte counts after PSE and splenectomy were observed in all patients. PSE was associated with improved liver function without severe complications, and no significant changes in emotional and neurological symptoms were observed. In contrast, seven WD patients suffered neurological deterioration after splenectomy. Conclusions: Hypersplenism in WD patients was successfully treated by PSE, which appears to be a safe and effective alternative treatment for WD-induced hypersplenism.

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Role of partial splenic arterial embolization for hypersplenism in patients with liver cirrhosis and thrombocytopenia

Abstract: Our data suggest that partial splenic arterial embolization leads to an increase in platelet count in patients with thrombocytopenia due to chronic liver disease and hypersplenism. However, it is often associated with complications.

Cited by 17 publications

References 18 publications

Resolution of Hypersplenism and Pancytopenia in Common Variable Immunodeficiency Patient After Partial Splenic Artery Embolization: A Case Report and Review of Literature

Resolution of Hypersplenism and Pancytopenia in Common Variable Immunodeficiency Patient After Partial Splenic Artery Embolization: A Case Report and Review of Literature

Radiofrequency Ablation versus Partial Splenic Artery Embolization in Hypersplenism

Successful Treatment of Hypersplenism in Wilson's Disease by Partial Splenic Embolization

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