Role of paraventricular hypothalamic dopaminergic D1 receptors in food intake regulation of food-deprived rats

Mirmohammadsadeghi, Zahra; Brojeni, Masoud Shareghi; Haghparast, Abbas; Eliassi, Afsaneh

doi:10.1016/j.ejphar.2017.10.028

Cited by 11 publications

(3 citation statements)

References 50 publications

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“…Dopamine has the ability to modulate food consumption by both reward (hedonic) and hypothalamic (homeostatic) pathways 1 . Among the five dopamine receptors (D1R, D2R, D3R, D4R and D5R), dopamine signaling through D1R [2][3][4] and D2R regulates food intake 1,[5][6][7] . The increase in central dopaminergic signaling is often associated to the stimulation of feeding, while its decrease has the opposite effect; however in the hypothalamus, the effects on food intake depend on the hypothalamic area targeted 8 .…”

Section: Introductionmentioning

confidence: 99%

Hypothalamic dopamine signalling regulates brown fat thermogenesis

et al. 2019

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Dopamine signaling is a crucial part of the brain reward system and can affect feeding behavior. Dopamine receptors are also expressed in the hypothalamus, which is known to control energy metabolism in peripheral tissues. Here we show that pharmacological or chemogenetic stimulation of dopamine receptor 2 (D2R) expressing cells in the lateral hypothalamic area (LHA) and the zona incerta (ZI) decreases body weight and stimulates brown fat activity in rodents in a feedingindependent manner. LHA/ZI D2R stimulation requires an intact sympathetic nervous system and orexin system to exert its action and involves inhibition of PI3K in the LHA/ZI. We further demonstrate that, as early as 3 months after onset of treatment, patients treated with the D2R agonist cabergoline experience an increase in energy expenditure that persists for one year, leading to total body weight and fat loss through a prolactin-independent mechanism. Our results may provide a mechanistic explanation for how clinically used D2R agonists act in the CNS to regulate energy balance.

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Section: Introductionmentioning

confidence: 99%

Hypothalamic dopamine signalling regulates brown fat thermogenesis

et al. 2019

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“…To date, at least 5 dopamine receptors have been classified into two families of D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptors (Sunahara et al, 1991;Van Tol et al, 1991). Our previous studies and others have shown that modulation of the hypothalamic D1 and D2 dopamine receptor activity could modulate food intake (Mirmohammadsadeghi, Brojeni, Haghparast, & Eliassi, 2018;Salimi, Eliassi, & Haghparast, 2015). Although D1 and D2 dopamine receptors also exist in the VTA and participate in behavioral rewards (Galaj, Manuszak, Arastehmanesh, & Ranaldi, 2014;White & Wang, 1984), its modulatory action on standard chow behavior has remained unexplored.…”

Section: Discussionmentioning

confidence: 99%

Ventral Tegmental Area Microinjected-SKF38393 Increases Regular Chow Intake in 18 Hours Food-Deprived Rats

Rad

Haghparast

Eliassi

2020

BCN

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Introduction: Ventral Tegmental Area (VTA) dopamine neurons play an important role in reward mechanisms of food intake, and VTA dopamine receptors exist on the terminal of glutamatergic and GABAergic neurons and regulate Gamma-Aminobutyric Acid (GABA) and glutamate release. To our knowledge, no evidence indicates any role for VTA D1 dopamine receptors in regular chow intake. Methods: In this paper, different dose of SKF38393, a D1 receptor agonist, was microinjected in VTA of 18-h food deprived-conscious rats and food intake was measured. Results: Our results revealed that VTAmicroinjected SKF383993 increased regular chow intake in a dose-dependent manner. The SKF3833 stimulatory effect persisted over 2 h post-injection. The results showed that the SKF38393, at doses less than 5 μg, did not affect locomotor activities. Conclusion: VTA D1-like and/or serotonergic receptors may be involved in regulatory pathways. the current study suggests that VTA D1-like and/or serotonergic receptors not only affects food reward but is also involved in regulatory mechanisms of regular feeding.

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“…Therefore, over three continuous hours, the rats were removed from the first test cage and placed into their new test cage after each hour. [3031] The amounts of food left in the first test cage, including crumbs, were measured and the amounts consumed were calculated. Furthermore, the feeding trials were done normally between 9:00 am and 12:00 on rats deprived of food for 16–18 h.…”

Section: Methodsmentioning

confidence: 99%

Effects of Isolation and Social Subchronic Stresses on Food Intake and Levels of Leptin, Ghrelin, and Glucose in Male Rats

et al. 2018

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Background:Exposure to psychological stresses can be a reason for obesity. Therefore, identifying the effective nutritional mechanisms such as feeding markers is of high necessity for the psychological stress conditions. Hence, the present study investigates the effects of subchronic isolation and social stresses on food intake, body weight differences (BWD), and levels of leptin, ghrelin, and glucose in rats.Materials and Methods:Eighteen male rats were randomly allocated into three groups: control (Co), isolation stress (IS), and social stress (SS) groups. Rats were under stresses for 7 days. The food intake (for three continuous hours after 16–18 h of food deprivation), BWD, levels of ghrelin, leptin, and glucose were measured.Results:The results showed that the food intake significantly (P < 0.05) reduced during the 1st h in the SS group compared to the Co group. At the 2nd h, the food intake significantly (P < 0.001 and P < 0.01, respectively) decreased in the IS group compared to the Co and SS groups. The cumulative food intake and body weight were significantly (P < 0.05) reduced in the IS group compared to the Co group. The serum ghrelin level significantly reduced in the IS group compared to the Co group.Conclusions:The subchronic psychological stresses led to a reduction in food intake by the reduction of serum ghrelin levels. It seems that ghrelin might have a more fundamental role in the food intake with respect to the leptin and glucose levels in subchronic stress condition. Furthermore, the decreased body weight justified the reduction of food intake, particularly in subchronic isolation stress.

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Role of paraventricular hypothalamic dopaminergic D1 receptors in food intake regulation of food-deprived rats

Cited by 11 publications

References 50 publications

Hypothalamic dopamine signalling regulates brown fat thermogenesis

Hypothalamic dopamine signalling regulates brown fat thermogenesis

Ventral Tegmental Area Microinjected-SKF38393 Increases Regular Chow Intake in 18 Hours Food-Deprived Rats

Effects of Isolation and Social Subchronic Stresses on Food Intake and Levels of Leptin, Ghrelin, and Glucose in Male Rats

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