Role of para-hydroxylation in phensuximide-induced urotoxicity in the Fischer 344 rat

Rankin, Gary O.; Beers, K. W.; Nicoll, Derek W.; Anestis, Dianne K.; Shih, Hsiencheng; Brown, Patrick I.; Hubbard, John L.

doi:10.1016/0300-483x(92)90045-g

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…The exact nature of the urotoxic metabolite(s) of phensuximide has not been clearly established. Several studies with meta-or parasubstituted phenyl derivatives of phensuximide have suggested that arene oxide metabolites of phensuximide do not contribute to phensuximide-induced urotoxicity (Jaklinski & Bryc, 1975;Rankin et al, 1990aRankin et al, , 1992a. The only difference between methsuximide and phensuximide is the presence of the 2-methyl group in methsuximide ( Figure 4).…”

Section: Nephrotoxicity In Animal Modelsmentioning

confidence: 99%

Mobile Telephones and Cancer—a Review of Epidemiological Evidence

Kundi

Mild²,

Hardell

et al. 2004

Journal of Toxicology and Environmental Health, Part B

135

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There is considerable public concern about possible long-term adverse health effects of mobile phones. While there is scientific controversy about long-term health effects of high-frequency electromagnetic fields lasting for at least 50 yr, the rise and success of mobile telecommunication made it necessary to investigate the problem more comprehensively and assess the possible risk cautiously because never before in history has a substantial proportion of the population been exposed to microwaves in the near field and at comparably high levels. Because the mostly localized exposure target region is the head, most epidemiological studies focus on brain tumors. Overall nine epidemiological studies have been published, four from the United States, two from Sweden, and one each from Denmark, Finland, and Germany. Seven studies were mainly on brain tumors, with one investigating in addition to brain tumors salivary gland cancer and another cancer of the hematopoietic and lymphatic tissues, and one examining intraocular melanoma. All studies have some methodological deficiencies: (1) too short duration of mobile phone use to be helpful in risk assessment, (2) exposure was not rigorously determined, and (3) there is a possibility of recall and response error in some studies. Nevertheless, all studies approaching reasonable latencies found an increased cancer risk associated with mobile phone use. Estimates of relative risk in these studies vary between 1.3 and 4.6 with highest overall risk for acoustic neuroma (3.5) and uveal melanoma (4.2), and there is evidence for enhanced cancer risk with increasing latency and duration of mobile phone use.

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Section: Nephrotoxicity In Animal Modelsmentioning

confidence: 99%

Mobile Telephones and Cancer—a Review of Epidemiological Evidence

Kundi

Mild²,

Hardell

et al. 2004

Journal of Toxicology and Environmental Health, Part B

135

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Older Anticonvulsants Continuing in Use but with Limited Advance in Knowledge

Eadie¹,

Vajda²

1999

Antiepileptic Drugs

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Nephrotoxicity Induced by C- And N-Arylsuccinimides

Rankin¹

2004

Journal of Toxicology and Environmental Health, Part B

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The succinimide ring is incorporated into hundreds of compounds that are widely used as agricultural, industrial, and pharmaceutical agents. Some succinimide derivatives that contain an aryl group on the ethylene bridge of the succinimide ring (C-arylsuccinimides) or on the nitrogen atom (N-arylsuccinimides) induce nephrotoxicity in humans and/or laboratory animals. Acute toxicity induced by this general class of compounds is typically characterized as polyuric renal failure, while chronic nephrotoxicity is seen as chronic interstitial nephritis. In this review, the structure-nephrotoxicity relationships, biotransformation, and mechanisms of nephrotoxicity for the C- and N-arylsuccinimides are examined.

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Role of para-hydroxylation in phensuximide-induced urotoxicity in the Fischer 344 rat

Cited by 3 publications

References 14 publications

Mobile Telephones and Cancer—a Review of Epidemiological Evidence

Mobile Telephones and Cancer—a Review of Epidemiological Evidence

Older Anticonvulsants Continuing in Use but with Limited Advance in Knowledge

Nephrotoxicity Induced by C- And N-Arylsuccinimides

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