Role of papillary thyroid carcinoma patients with Hashimoto thyroiditis: evaluation of oxidative stress and inflammatory markers

Lopes, Natália Medeiros Dias; Lens, Hannah Hamada Mendonça; Brito, Walison Augusto da Silva; Bianchi, Julya Karen; Marinello, Poliana Camila; Cecchini, Rúbens; Armani, André; Cecchini, Alessandra Lourenço

doi:10.1007/s12094-022-02891-y

Cited by 5 publications

(2 citation statements)

References 60 publications

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“…Under normal conditions, thyroid hormones in the thyroid tissue form an oxidative environment during the synthesis process, and the thyroid itself has a complete antioxidant oxidase system, such as TPO, glutathione peroxidase, thioredoxin, etc., which constitutes an antioxidant barrier to protect the thyroid from oxidative stress [9].If the thyroid gland is injured or the thyroid hormone level is disturbed, the level of free radicals will increase and the oxidation balance in the thyroid gland will be destroyed [10].Excessive free radicals can cause damage to thyroid structural cells, destroy genomic stability, and promote the occurrence and progression of thyroid cancer. In addition, thyroid hormone plays a metabolic regulatory function by in uencing mitochondrial activity, and because its function depends on reactive oxygen species, the thyroid is particularly vulnerable to oxidative damage [11].Superoxide dismutase (SOD) is the most powerful antioxidant and free radical scavenger to defend against oxidative attack in human body, and is considered to be the rst line of defense of the antioxidant system in human body [12].Nitric oxide, a free radical gas synthesized by nitric oxide synthase, is synergistically elevated due to oxidative stress [13].…”

Section: Discussionmentioning

confidence: 99%

Role of oxidative stress and IL-17 induced inflammatory cytokines in thyroid carcinoma with Hashimoto's thyroiditis

xing,

lu,

Liu

et al. 2023

Preprint

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Objective: To investigate the expression changes and mechanism of oxidative stress and IL-17 induced inflammatory factors in thyroid cancer with Hashimoto's thyroiditis. Method: 40 patients with thyroid cancer accompanied by Hashimoto's thyroiditis were selected as the PTC+HT group, 45 patients with simple thyroid cancer as the PTC group, 42 patients with simple Hashimoto's thyroiditis as the HT group, and 40 healthy individuals as the control group (NC). Evaluate the oxidative stress indicators NO, eNOS, superoxide dismutase (SOD), inflammatory indicators IL-17A, IL-1β and IL-6, thyroid hormones and their antibodies TPOAb and TGAb, as well as related biochemical indicators. Result: The inflammatory and oxidative stress indicators such as IL-17A were significantly increased in the PTC and HT groups compared to the control group, while the PTC+HT group further increased; There was a significant difference in thyroid hormone levels between the PTC+HT group and the HT group compared to the control group (P<0.05); TPOAb, TGAb and NO, eNOS, IL-17A, IL-1 β、IL-6 showed a significant positive correlation and a significant negative correlation with SOD (P<0.05); eNOS, SOD, and IL-17A are risk factors for these three different diseases. Conclusion: IL-17 and its induced inflammatory factors and oxidative stress are highly expressed in PTC+HT, and the synergistic effect between inflammation and oxidative stress leads to thyroid hormone levels and antibody abnormalities in PTC+HT patients. eNOS, SOD, and IL-17A can serve as effective indicators for predicting the occurrence and evaluating changes in PTC+HT disease, and also provide a theoretical basis for future treatment of PTC+HT.

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Section: Discussionmentioning

confidence: 99%

Role of oxidative stress and IL-17 induced inflammatory cytokines in thyroid carcinoma with Hashimoto's thyroiditis

xing,

lu,

Liu

et al. 2023

Preprint

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“…An increasing ndings support that the blood immune indicators are recognized as important factors in the development and prognosis of malignant tumors, including PTC [11][12][13]. Some in ammatory indicators, including neutrophils (N), lymphocytes (L), monocytes (M), platelets (Plt), lymphocyte-tomonocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-in ammatory index (SII) are considered effective predictors in many malignant tumors [14][15][16][17].…”

Section: Introductionmentioning

confidence: 96%

A Retrospective Analysis: A Predictive Model Using Platelets and Neutrophil-to- Lymphocyte Ratio for the Number of Lymph Node Metastasis in Papillary Thyroid Carcinoma

Chen,

Wu,

et al. 2024

Preprint

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Objective The aim of this study was to investigate the high-risk clinical factors for large-number lymph node metastases (LNLNM) inthyroid papillary carcinoma (PTC). Methods The clinicopathological data from the 731 PTC patients who underwent thyroid operation between September 2021to October 2022 in the surgical oncology of Affiliated Hangzhou First People’s Hospital, Westlake University School of Medicine were collected. Univariate and multivariate logistic analyses were conducted to identify risk factors for LNLNM in PTC. A predictive model for assessing LNLNM in PTC was established and validated by using receiver operating characteristic curves (ROC), the Hosmer-Lemeshow (HL)test, calibration curves, and decision curve analysis (DCA). Results Age, tumor diameter, platelets and neutrophil-to-lymphocyte ratio (NLR) were identified as independent risk factors for LNLNM in PTC patients. A predictive model was developed to evaluate the risk of LNLNMwith an area under the curve (AUC) of 0.827 (P<0.001, 95%CI: 0.784-0.870) and the specificity and sensitivity were both 75.8%. The AUC of the validation group was 0.824(P<0.001, 95%CI: 0.757-0.890) with a specificity of 79.5% and a sensitivity of 76.0%. Furthermore, themodel demonstrated good calibration through the HL test and favorable diagnostic value by calibration curve and DCA. Conclusion Age, tumor diameter, platelets and NLRare high-risk factors for LNLNM in PTC, and the predictive model established in combination with the above factors couldeffectively predict the occurrence of LNLNM in PTC. This study provides support for surgeons to accurately predict the possibility of LNLNM and develop personalized treatment plans before surgery.

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Predicting tall-cell subtype of papillary thyroid carcinomas independently with preoperative multimodal ultrasound

Ye,

Liu,

Zhang

et al. 2024

British Journal of Radiology

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Objectives This study aimed to explore the differences between tall-cell subtype of papillary thyroid carcinoma (TCPTC) and classical papillary thyroid carcinoma (cPTC) using multimodal ultrasound, and identify independent risk factors for TCPTC to compensate the deficiency of preoperative cytological and molecular diagnosis on PTC subtypes. Methods 46 TCPTC patients and 92 cPTC patients were included. Each patient received grey-scale ultrasound, color Dopplor flow imaging (CDFI) and shear-wave elastography (SWE) preoperatively. Clinicopathologic information, grey-scale ultrasound features, CDFI features and SWE features of 98 lesion were compared using univariate analysis to find out predictors of TCPTC, based on which, a predictive model was built to differentiate TCPTC from cPTC and validated with 40 patients. Results Univariate and multivariate analysis identified that extrathyroidal extension (OR, 15.12; 95% CI, 2.26-115.44), aspect ratio (≥0.91) (OR, 29.34; 95% CI, 1.29-26.23), and maximum diameter ≥ 14.6 mm (OR, 20.79; 95% CI, 3.87-111.47) were the independent risk factors for TCPTC. Logistic regression equation: p = 1/1+ExpΣ[-5.099 + 3.004 × (if size ≥14.6 mm)+2.957 × (if aspect ratio≥0.91)+2.819 × (if extra-thyroidal extension)]. The prediction model had a good discrimination performance for TCPTC: the AUC, sensitivity and specificity were 0.928, 0.848 and 0.954 in cohort 1, and the corresponding values in cohort 2 were 0.943, 0.923 and 0.926. Conclusion Ultrasound has potential for differential diagnosis of TCPTC from cPTC. A prediction model based on ultrasound characteristics (extrathyroidal extension, aspect ratio ≥0.91, and maximum diameter ≥14.6 mm) was useful to predict TCPTC. Advances in knowledge Multimodal ultrasound prediction of TCPTC were supplements to preoperative cytological diagnosis and molecular diagnosis on PTC subtypes.

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Role of papillary thyroid carcinoma patients with Hashimoto thyroiditis: evaluation of oxidative stress and inflammatory markers

Cited by 5 publications

References 60 publications

Role of oxidative stress and IL-17 induced inflammatory cytokines in thyroid carcinoma with Hashimoto's thyroiditis

Role of oxidative stress and IL-17 induced inflammatory cytokines in thyroid carcinoma with Hashimoto's thyroiditis

A Retrospective Analysis: A Predictive Model Using Platelets and Neutrophil-to- Lymphocyte Ratio for the Number of Lymph Node Metastasis in Papillary Thyroid Carcinoma

Predicting tall-cell subtype of papillary thyroid carcinomas independently with preoperative multimodal ultrasound

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