Role of Papain-Like Cysteine Proteases in Plant Development

Liu, Huijuan; Hu, Menghui; Wang, Qi; Cheng, Lin; Zhang, Zaibao

doi:10.3389/fpls.2018.01717

Cited by 102 publications

(83 citation statements)

References 92 publications

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Section: Involvement Of Papain-like Kdel-cys-eps In Seed Lifementioning

confidence: 99%

“…Papain-like Cys-EPs (PLCPs; often called cathepsins in animals) are essential and central hubs of plant immunity, germination, development, and senescence [45,46]. Thus, when activated, PLCPs induce a broad spectrum of defense responses, including PCD [46]. On the other hand, PLCPs constitute one of the most abundant groups of the proteases responsible for the degradation and mobilization of SPs in seeds [47].…”

Section: Involvement Of Papain-like Kdel-cys-eps In Seed Lifementioning

confidence: 99%

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Programmed Cell Death in Seeds: An Adaptive Mechanism Required for Life

Matilla¹

2020

Seed Dormancy and Germination

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The regeneration of the mother plant through germinative process is the main reason that evolutionarily justifies the existence of a viable seed. Current knowledge indicates that the control of germination is a sophisticated process mainly controlled by hormones and reactive oxygen species (ROS), among other endogenous factors. One of the events that directly participate in the germination is the degradation of storage proteins (SPs). Thus, vacuolar processing enzymes (VPEs) contribute to SPs' degradation and mobilization due to direct proteolysis or through the activation of other peptidases. In parallel, the relationship between VPEs and programmed cell death (PCD) is beyond doubt. As an alternative to VPEs, the formation of vesicles called ricinosomes containing papain-like Cys-proteases (PLCPs) and located in the reserve tissues of some germinating seeds also collaborates to protein degradation. Finally, there are increasing evidences linking nucleases to PCD in different tissues of seed. However, its state of the art is still little developed. Together, this current overview illustrates a part of the complexity of PCD in seeds, a puzzle far from being solved.

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Section: Involvement Of Papain-like Kdel-cys-eps In Seed Lifementioning

confidence: 99%

Section: Involvement Of Papain-like Kdel-cys-eps In Seed Lifementioning

confidence: 99%

Programmed Cell Death in Seeds: An Adaptive Mechanism Required for Life

Matilla¹

2020

Seed Dormancy and Germination

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“…Papain-like cysteine proteases (PLCPs), featuring a nucleophilic cysteine thiol at the active site, are coded by a multigene family (with at least 31 members in Arabidopsis). These genes contribute to a plethora of physiological procedures, such as seed germination, anther development, programmed cell death, senescence, abiotic stress responses and plant innate immunity system [54]. In the apoplast, the vast majority of proteases, recognizing different pathogen types and transmitting the respective messages, belongs to PLCPs.…”

Section: Papain-like Cysteine Proteasesmentioning

confidence: 99%

The Role of Proteases in Determining Stomatal Development and Tuning Pore Aperture: A Review

Fanourakis

Nikoloudakis

Pappi³

et al. 2020

Plants

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Plant proteases, the proteolytic enzymes that catalyze protein breakdown and recycling, play an essential role in a variety of biological processes including stomatal development and distribution, as well as, systemic stress responses. In this review, we summarize what is known about the participation of proteases in both stomatal organogenesis and on the stomatal pore aperture tuning, with particular emphasis on their involvement in numerous signaling pathways triggered by abiotic and biotic stressors. There is a compelling body of evidence demonstrating that several proteases are directly or indirectly implicated in the process of stomatal development, affecting stomatal index, density, spacing, as well as, size. In addition, proteases are reported to be involved in a transient adjustment of stomatal aperture, thus orchestrating gas exchange. Consequently, the proteases-mediated regulation of stomatal movements considerably affects plants’ ability to cope not only with abiotic stressors, but also to perceive and respond to biotic stimuli. Even though the determining role of proteases on stomatal development and functioning is just beginning to unfold, our understanding of the underlying processes and cellular mechanisms still remains far from being completed.

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“…They have structures similar to papain from Carica papaya and possess cysteine, histidine, and asparagine in the catalytic center [ 6 ]. They have been found in most living organisms and conduct multiple functions, such as matrix turnover and antigen presentation in animals [ 7 ] and senescence and regulated cell death in plants [ 8 , 9 ]. This made them perspective targets for inhibition and induced intensive study of PLCPs over the last years.…”

Section: Introductionmentioning

confidence: 99%

Papain-Like Proteases as Coronaviral Drug Targets: Current Inhibitors, Opportunities, and Limitations

Petushkova

Zamyatnin

2020

Pharmaceuticals

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Papain-like proteases (PLpro) of coronaviruses (CoVs) support viral reproduction and suppress the immune response of the host, which makes CoV PLpro perspective pharmaceutical targets. Their inhibition could both prevent viral replication and boost the immune system of the host, leading to the speedy recovery of the patient. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the third CoV outbreak in the last 20 years. Frequent mutations of the viral genome likely lead to the emergence of more CoVs. Inhibitors for CoV PLpro can be broad-spectrum and can diminish present and prevent future CoV outbreaks as PLpro from different CoVs have conservative structures. Several inhibitors have been developed to withstand SARS-CoV and Middle East respiratory syndrome CoV (MERS-CoV). This review summarizes the structural features of CoV PLpro, the inhibitors that have been identified over the last 20 years, and the compounds that have the potential to become novel effective therapeutics against CoVs in the near future.

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Role of Papain-Like Cysteine Proteases in Plant Development

Cited by 102 publications

References 92 publications

Programmed Cell Death in Seeds: An Adaptive Mechanism Required for Life

Programmed Cell Death in Seeds: An Adaptive Mechanism Required for Life

The Role of Proteases in Determining Stomatal Development and Tuning Pore Aperture: A Review

Papain-Like Proteases as Coronaviral Drug Targets: Current Inhibitors, Opportunities, and Limitations

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