Role of PAI-1 and TAFI in the mediation of fibrinolytic deficit in cancer patients

Florian-Kujawski, M.; Hoppensteadt, Debra; Iqbal, Omar; Demir, Mustafa Kemal; Tobu, M.; Fareed, D.; Fareed, J.

doi:10.1200/jco.2004.22.14_suppl.9727

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2011

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“…Florian-Kujawski et al [15] showed increases in both PAI-1 and TAFI levels in cancer patients, which may cause the fibrinolytic deficiency. Similarly, in a study by Hataji et al [14] , TAFI levels were found to be increased in SCC patients.…”

Section: Discussionmentioning

confidence: 99%

Thrombin-Activatable Fibrinolysis Inhibitor in Breast Cancer Patients

Kaftan¹,

Kasapoğlu²,

Köroğlu³

et al. 2011

Med Princ Pract

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Objective: To evaluate the levels of thrombin-activatable fibrinolysis inhibitor (TAFI) activity and also its relationship with other homeostasis markers in breast cancer patients. Subjects and Methods: Forty-two female patients with breast cancer and 24 healthy women (controls) were enrolled in the study and fasting blood samples of all cases were drawn from a large antecubital vein for assay of TAFI and other homeostasis tests. Results: The TAFI levels were 79.5 ± 15.5 and 39.3 ± 12.1 in patients and controls, respectively, and the difference was statistically significant (p < 0.001). In the patient group, the serum fibrinogen level was 504.9 ± 224.8, while in the control group it was 393.9 ± 100.5, and the difference was also statistically significant (p < 0.001). Conclusion: The data showed that increased levels of TAFI are a contributing factor of thrombotic disorders in breast cancer patients.

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Section: Discussionmentioning

confidence: 99%