Role of p63/p73 in epithelial remodeling and their response to steroid treatment in nasal polyposis

Li, Chun Wei; Li, Shi; Zhang, Ke Ke; Li, Tian Ying; Lin, Zhi; Lim, Mei Kee; McKeon, Frank; Xian, Wa; Wang, De Yun

doi:10.1016/j.jaci.2010.12.011

Cited by 57 publications

(74 citation statements)

References 43 publications

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“…Eosinophilia and airway remodeling are 2 major histological hallmarks that suggest the same pathologic disease process. [289][290][291][292] Epidemiological and clinical studies have consistently shown that CRS and asthma frequently coexist in the same patient. In a recent random sample survey study with over 52,000 adults aged 18 to 75 years in 12 European countries, the prevalence of self-reported current asthma (5.1-16.8%) was found to be strongly associated with CRS appropriate symptoms (adjusted OR, 3.47; 95% CI, 3.20 to 3.76) in all ages, in both men and women, irrespective of smoking behavior.…”

Section: Viib Crssnp: Comorbid Asthmamentioning

confidence: 99%

“…In a recent random sample survey study with over 52,000 adults aged 18 to 75 years in 12 European countries, the prevalence of self-reported current asthma (5.1-16.8%) was found to be strongly associated with CRS appropriate symptoms (adjusted OR, 3.47; 95% CI, 3.20 to 3.76) in all ages, in both men and women, irrespective of smoking behavior. 293 The reported incidence of asthma varies from 2% to 38% in patients with CRS, [294][295][296][297][298][299] 2% to 66% in CRSwNP, 289, and 68% to 91% in refractory CRSwNP. 290,299 Among these reports, the prevalence of asthma in patients with CRSsNP or CRSwNP appears to be lower in Asians than whites.…”

Section: Viib Crssnp: Comorbid Asthmamentioning

confidence: 99%

See 1 more Smart Citation

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

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554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: Viib Crssnp: Comorbid Asthmamentioning

confidence: 99%

Section: Viib Crssnp: Comorbid Asthmamentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

554

888

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show abstract

“…15 The epithelial cell genes p63 and p73 are members of the p53 gene family, but unlike the tumor suppressor gene p53, overexpression of p63 and p73 is associated with cell proliferation. 9 Expression of p63 and p73 was higher in nasal polyp (NP) epithelium than in inferior turbinate epithelium from healthy subjects. Levels of p63 correlated with the degree of epithelial hyperplasia in NPs.…”

Section: Sinusitis Pathogenesismentioning

confidence: 99%

“…We start with the key advances in upper airway diseases, which are summarized in Table I. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] …”

mentioning

confidence: 99%

Advances in upper airway diseases and allergen immunotherapy in 2011

Hsu

Saltoun

Avila

2012

Journal of Allergy and Clinical Immunology

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“…Additionally, p63 could suppress the expression level of miR-193a-5p, while the proapoptotic p73 isoforms in both normal cells and tumor cells could enhance miR-193a-5p expression [102]. Chemotherapy will contribute to p63/ p73-dependent induction of miR-193a-5p.…”

Section: New Prospects Of Mirna In Cancer Clinical Application Mirna mentioning

confidence: 99%