Role of p14ARF alterations in endometrial tumorigenesis a mini-review

Abstract

In the current mini-review, we present a short overview of genetic as well as immunohistochemical p14(ARF) alterations either in primary human endometrial carcinomas (ECs) or in metastatic lesions originated from malignant endometrium. The prognostic utility of p14(ARF) in uterine malignancies has also been briefly discussed.

Role of p53 Pathway Alterations in Uterine Carcinosarcomas (Malignant Mixed Müllerian Tumors)

“…Data concerning the role of alterations in p14 ARF in primary ECs and CSs are strictly limited [114,115,116,117,118,119,120]. A mini-review article concerning the role of p14 ARF alterations during endometrial tumorigenesis has recently been published [114]. More than half of the primary human ECs and corresponding metastatic lesions displayed a p14 ARF expression pattern [119].…”

“…In general, p14 ARF increases MDM and p21 levels and leads to cell cycle arrest in G1 and G2/M phases of the cell cycle [111,112,113]. Data concerning the role of alterations in p14 ARF in primary ECs and CSs are strictly limited [114,115,116,117,118,119,120]. A mini-review article concerning the role of p14 ARF alterations during endometrial tumorigenesis has recently been published [114].…”