Role of Ozone Therapy and Cancer: Myth or Reality?

Agarwal, Bhaskar

doi:10.18535/jmscr/v7i7.127

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…Ozone therapy has subsequently been used as an adjunctive medical treatment in various medical conditions, including cancer. 10 - 13 …”

Section: Introductionmentioning

confidence: 99%

Ozone Therapy for Breast Cancer: An Integrative Literature Review

Li,

2024

Integr Cancer Ther

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Breast cancer is the most prevalent form of cancer in women. Despite significant advances in conventional treatment, additional safer complementary treatment options are needed. Recently, ozone therapy has been considered as a type of medical adjunctive treatment that could inhibit cancer cell survival and reduce chemoresistance. However, only a few studies have been conducted on its use in breast cancer, and the optimal dosage and time of administration are unknown. Currently, preclinical studies suggest that ozone alone or in combination with chemotherapy is an effective method for inhibiting breast cancer cell growth. However, rather than investigating the effects of ozone as an antitumor therapy, current clinical trials have generally assessed its effect as an adjunctive therapy for reducing chemotherapy-induced side effects, increasing oxygen tension, normalizing blood flow, restoring blood lymphocytes more rapidly, and reducing fatigue symptoms. In this article, the use of ozone as a medical adjunctive treatment for breast cancer and its role in integrative therapy are summarized and discussed.

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“…Ozone therapy has subsequently been used as an adjunctive medical treatment in various medical conditions, including cancer. 10 - 13 …”

Section: Introductionmentioning

confidence: 99%

Ozone Therapy for Breast Cancer: An Integrative Literature Review

Li,

2024

Integr Cancer Ther

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“…Despite substantial advancements in conventional treatments, there is a growing demand for innovative therapeutic strategies that can control neoplastic growth and dissemination along with fewer adverse reactions, especially in patients at advanced stages of the disease [ 2 , 3 ]. In this context, adjuvant therapy using the gas mixture of oxygen–ozone (O 2 –O 3 ) emerges as a promising alternative for the treatment of various types of cancer due to its immunomodulatory, anti-inflammatory, and oxidative stress-inducing properties [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Ozone Therapy in the Integrated Treatment of Female Dogs with Mammary Cancer: Oxidative Profile and Quality of Life

Silva,

Portela,

Machado

et al. 2024

Antioxidants

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Considering the high frequency of malignant breast tumors, there is a growing search for new therapeutic strategies that control neoplastic growth and dissemination, combined with fewer adverse reactions. Therefore, this study evaluated the effects of ozone therapy in female dogs with mammary cancer undergoing chemotherapy treatment. Twenty-five canines diagnosed with malignant mammary neoplasia were divided into two groups: one treated with carboplatin alone (n = 11) and the other with carboplatin associated with ozone therapy (n = 14). Clinical and laboratory evaluations, mastectomy, analysis of the oxidative profile based on total antioxidant capacity (TAC) and serum concentrations of malondialdehyde (MDA), survival rate, and quality of life were performed. Animals in the ozone therapy group had higher concentrations of red blood cells and platelets, significantly improving the survival rate and quality of life. Furthermore, adverse reactions were less intense and frequent in this group, which was associated with an increase in TAC and a reduction in MDA. These results indicate that the combination of carboplatin and ozone therapy represents a promising complementary treatment for female dogs with mammary cancer, as it was associated with fewer adverse reactions and a better oxidative profile.

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“…Additionally, ozone can increase the oxygen concentration in tissues, boost the immune system, and induce antimicrobial effects capable of producing chromosome breakages in human cell cultures (4). As such, ozone therapy has been used to treat a variety of medical conditions, including cancer (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Ozone therapy for high-grade glioma: an overview

Pu²,

Cao

et al. 2023

Front. Oncol.

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High-grade gliomas (grades III and IV) are highly malignant and aggressive brain tumors that present significant treatment challenges. Despite advances in surgery, chemotherapy, and radiation therapy, the prognosis for patients with glioma remains poor, with a median overall survival (mOS) range of 9–12 months. Therefore, exploring new and effective therapeutic strategies to improve glioma prognosis is of utmost importance and ozone therapy is a viable option. Ozone therapy has been used in various cancers, such as colon, breast, and lung, yielding significant results in preclinical studies and clinical trials. Only a few studies have been conducted on gliomas. Furthermore, since the metabolism of brain cells involves aerobic glycolysis, ozone therapy may improve the oxygen condition and enhance glioma radiation treatment. However, understanding the correct ozone dosage and optimal time of administration remains challenging. Herein, we hypothesize that ozone therapy should be more effective in gliomas compared with other tumors. This study provides an overview of the use of ozone therapy in high-grade glioma, including mechanisms of action, preclinical data, and clinical evidence.

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Role of Ozone Therapy and Cancer: Myth or Reality?

Cited by 4 publications

References 20 publications

Ozone Therapy for Breast Cancer: An Integrative Literature Review

Ozone Therapy for Breast Cancer: An Integrative Literature Review

Ozone Therapy in the Integrated Treatment of Female Dogs with Mammary Cancer: Oxidative Profile and Quality of Life

Ozone therapy for high-grade glioma: an overview

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