Role of Oxytocin in Different Neuropsychiatric, Neurodegenerative, and Neurodevelopmental Disorders

Ghazy, Aya A; Soliman, Omar S.; Elbahnasi, Aya I; Alawy, Aya Y; Mansour, Alaa; Gowayed, Mennatallah A.

doi:10.1007/112_2022_72

Cited by 10 publications

(6 citation statements)

References 183 publications

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“…The potential clinical usefulness of OT as adjunctive drug therapy in PD patients would be therefore based also on the possibility to reduce the dopaminergic therapy side effects, including the impulsivity disorders mainly in patients with addictive behaviors. As a matter of fact, evidence in animal PD models is provided that OT administration may possess neuroprotective effects on dopaminergic neurons related to anti-inflammatory, antioxidant, and anti-apoptotic activities [103], that dopamine levels increased when OT was administrated [104], that the OT levels were decreased in the models, that OT supplementation rescued locomotor disabilities and anxiety-like behaviors [101], and that after intranasal administration OT concentrates in brain regions including the striatum [105]; nevertheless, studies investigating OT in PD clinical settings are still needed [106]. In fact, critical examinations appear fundamental for enabling the utilization of OT mechanisms as a curative tool in psychiatric disorders, in particular when considering that the understanding of how OT impacts social behavior is still insufficient, life experience can change the OT systems function, and the OT effects appear highly context-dependent [107].…”

Section: Potential Relevance Of Striatal Astrocytic D2-otr Heteromersmentioning

confidence: 99%

Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes

Amato

Averna

Guidolin

et al. 2023

IJMS

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The ability of oxytocin (OT) to interact with the dopaminergic system through facilitatory D2-OT receptor (OTR) receptor-receptor interaction in the limbic system is increasingly considered to play roles in social or emotional behavior, and suggested to serve as a potential therapeutic target. Although roles of astrocytes in the modulatory effects of OT and dopamine in the central nervous system are well recognized, the possibility of D2-OTR receptor-receptor interaction in astrocytes has been neglected. In purified astrocyte processes from adult rat striatum, we assessed OTR and dopamine D2 receptor expression by confocal analysis. The effects of activation of these receptors were evaluated in the processes through a neurochemical study of glutamate release evoked by 4-aminopyridine; D2-OTR heteromerization was assessed by co-immunoprecipitation and proximity ligation assay (PLA). The structure of the possible D2-OTR heterodimer was estimated by a bioinformatic approach. We found that both D2 and OTR were expressed on the same astrocyte processes and controlled the release of glutamate, showing a facilitatory receptor-receptor interaction in the D2-OTR heteromers. Biochemical and biophysical evidence confirmed D2-OTR heterodimers on striatal astrocytes. The residues in the transmembrane domains four and five of both receptors are predicted to be mainly involved in the heteromerization. In conclusion, roles for astrocytic D2-OTR in the control of glutamatergic synapse functioning through modulation of astrocytic glutamate release should be taken into consideration when considering interactions between oxytocinergic and dopaminergic systems in striatum.

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Section: Potential Relevance Of Striatal Astrocytic D2-otr Heteromersmentioning

confidence: 99%

Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes

Amato

Averna

Guidolin

et al. 2023

IJMS

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“…Oxytocin neurons in the SCN, SON, and PVN project to the PP gland and secrete oxytocin into the circulating blood [7]. A previous study reported the presence of -synuclein-positive deposits in the PP glands of the majority of elderly patients with Parkinson's disease and Lewy body dementia; however, -synuclein-positive deposits were also present in the PP glands of elderly patients without these diseases [44].…”

Section: Discussionmentioning

confidence: 94%

“…Oxytocin is a pleiotropic peptide hormone with broad implications in general health, adaptation, development, behavior, and reproduction [6]. The cell bodies of oxytocin neurons are located in the suprachiasmatic nucleus (SCN), supraoptic nucleus (SON), and paraventricular hypothalamic nucleus (PVN), and their fibers project to various brain regions (to secrete oxytocin as neurotransmitter) or to the posterior pituitary (PP) gland (to secrete oxytocin as hormone into the blood) [7]. Oxytocin is a potential therapeutic target for brain diseases such as Alzheimer's disease and Parkinson's disease in the elderly [7].…”

Section: Introductionmentioning

confidence: 99%

Alpha-synuclein expression in oxytocin neurons of young and old bovine brains

NIYONZIMA,

ASATO,

KADOKAWA

2024

J. Reprod. Dev.

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Understanding of central nervous system mechanisms underlying age-related infertility remains limited. Fibril -synuclein, distinct from its monomeric form, is implicated in age-related diseases.Notably, fibril -synuclein spreads among neurons, similar to prions, from damaged old neurons in cortex and hippocampus to healthy neurons. However, less is known whether -synuclein propagates into oxytocin neurons, which play crucial roles in reproduction. We compared -synuclein expression in the oxytocin neurons in suprachiasmatic nucleus (SCN), supraoptic nucleus (SON), paraventricular hypothalamic nucleus (PVN), and posterior pituitary (PP) gland of healthy heifers and aged cows to determine its role in age-related infertility. We analyzed mRNA and protein expression, along with Congo red histochemistry and fluorescent immunohistochemistry for oxytocin and -synuclein, followed by confocal microscopy with Congo red staining. Both mRNA and protein expressions of synuclein were confirmed in the bovine cortex, hippocampus, SCN, SON, PVN, and PP tissues.Significant differences in -synuclein mRNA expressions were observed in the cortex and hippocampus between young heifers and old cows. Western blots showed five bands of -synuclein, probably reflecting monomers, dimers, and oligomers, in the cortex, hippocampus, SCN, SON, PVN, and PP tissues, and there were significant differences in some bands between the young heifers and old cows.Bright-field and polarized light microscopy did not detect obvious amyloid deposition in the aged hypothalami; however, higher-sensitive confocal microscopy unveiled strong positive signals for Congo red and -synuclein in oxytocin neurons in the aged hypothalami. -synuclein was expressed in oxytocin neurons, and some differences were observed between young and old hypothalami.

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“…The halflife of the drug is 1 -6 min, and the effect of oxytocin depends on the number of oxytocin receptors in the body. When the receptor is saturated, increasing the dose does not enhance uterine contraction, but gives rise to various adverse reactions which limit the clinical application of oxytocin [16].…”

Section: Discussionmentioning

confidence: 99%

Effect of carboprost tromethamine and carbetocin on coagulation factors and prognosis in puerpera with postpartum hemorrhage due to uterine inertia

Chen,

Xiong,

Chen

et al. 2023

Trop. J. Pharm Res

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Purpose: To determine the effect of carboprost tromethamine and carbetocin on coagulation factors and prognosis in puerpera with postpartum hemorrhage due to uterine inertia.Methods: A total of 80 high-risk pregnant women with postpartum hemorrhage due to uterine inertia admitted to Longyan First Hospital Affiliated of Fujian Medical University, Longyan, China from June 2021 to June 2022 were randomly divided into control group (oxytocin + carboprost tromethamine, n = 40) and study group (oxytocin + carboprost tromethamine + carbetocin, n = 40). Vaginal bleeding volume was recorded for both groups at delivery, and 2 and 24 h after delivery. Decrease in hemoglobin level 24 h after delivery, as well as levels of coagulation factors, and adverse drug reactions before and after treatment were assessed.Results: The third stage of labor, postpartum hemorrhage at 2 and 24 h, and decrease in hemoglobin 24 h after delivery in the study group were lower (p < 0.05). Compared with that before treatment, PLT and FIB levels also fell, while APTT and PT levels rose in both groups after treatment for 24 h (p < 0.05). Platelet count and fibrinogen levels in the study group were lower after treatment for 24 h, but APTT and PT levels were higher (p < 0.05). There was no statistically significant difference in the incidence of adverse drug reactions between both groups (15.00 vs 12.50 %; p > 0.05).Conclusion: Co-administration of carboprost tromethamine with carbetocin prevents high-risk postpartum hemorrhage in pregnant women due to uterine inertia. It also reduces the level of bleeding, and promotes recovery of coagulation function. However, further clinical trials on a larger scale are recommended prior to the application of this treatment strategy in clinical practice.

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Role of Oxytocin in Different Neuropsychiatric, Neurodegenerative, and Neurodevelopmental Disorders

Cited by 10 publications

References 183 publications

Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes

Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes

Alpha-synuclein expression in oxytocin neurons of young and old bovine brains

Effect of carboprost tromethamine and carbetocin on coagulation factors and prognosis in puerpera with postpartum hemorrhage due to uterine inertia

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