Role of oxidative stress in infectious diseases. A review

Pohanka, Miroslav

doi:10.1007/s12223-013-0239-5

Cited by 126 publications

(95 citation statements)

References 122 publications

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“…Experimental rheumatoid arthritis is a typical consequence of an uncontrolled infl ammation initiated by FCA (16). Infl ammation is in a tight link to oxidative stress as a causative process and to depletion of low molecular weight antioxidants as well (17,18). In the results part, we showed both induction of infl ammation because of the TNF α level increase and oxidative stress arising because of the signifi cant augmentation of TBARS value representing malondialdehyde in both the liver and muscle tissue.…”

Section: Discussionmentioning

confidence: 57%

Freund´s complete adjuvant effect on BALB/c mice: an insight into inflammation and oxidative stress after immunity challenge

Pohanka¹,

Vobornikova²,

Fusek³

2016

BLL

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Freund´s complete adjuvant (FCA) is a mean used for improving immunization effi cacy in experiments and veterinary medicine. Despite high effi cacy, it is not used in human vaccination due to number of adverse effects. Arthritis can be an example of a typical adverse consequence. In this work, we decided to investigate the link between oxidative stress and infl ammation in animals exposed to FCA. BALB/c mice received either saline or FCA in doses 10-50 μl and were euthanized from one to three days after infection. Interleukins (IL) IL-2, IL-4 and tumor necrosis factor α (TNF-α) were determined in plasma. Ferric reducing antioxidant power (FRAP), malondialdehyde by thiobarbituric acid reactive substances assay (TBARS), reduced glutathione (GSH) and caspase-3 were measured in livers, muscles and other organs. We determined signifi cant effect of FCA on TBARS and GSH in the livers. Beside this, TBARS were altered in muscles as well. Infl ammation was confi rmed by increased level of TNF-α. Taking the results into account, we infer that the harmful effect of FCA is mediated not only by infl ammation but also by oxidative. This should be considered when pathological consequences of FCA are scored (Fig. 4, Ref. 21). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 57%

Freund´s complete adjuvant effect on BALB/c mice: an insight into inflammation and oxidative stress after immunity challenge

Pohanka¹,

Vobornikova²,

Fusek³

2016

BLL

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“…The rest of the structures present two types of substitution, xanthones 7, 10b and 12b with an extra ring linking rings B and D and xanthones 8b, 9b and 11b with unlinked substituents at carbons C-3 and C-4. The p-tolyl group at carbon C-3 presents the characteristic 1 H-NMR signals of a para substituted aromatic ring and the most distinguishable signals are: (i) the singlet at δ 4.10 ppm, due to the resonance of the benzylic CH 2 protons of 8b; (ii) the doublet at δ 6.02 ppm, due to the H-7" proton resonance proton and the broad singlet at δ 2.98 ppm, due to the 7"-hydroxyl group of xanthone 11b. The main feature of the 13 C-NMR spectrum of xanthone 9b is the carbonyl carbon resonance at δ 194.0 ppm.…”

Section: Nuclear Magnetic Resonance Spectroscopymentioning

confidence: 99%

“…These species are involved in several ailments including cancer, heart diseases and OPEN ACCESS apparently Alzheimer's disease (AD) [1]. Alzheimer's disease remains a mystery and a source of several discussions [2], but there is evidence that it is related with oxidative stress [3], as well as with cholinesterase activity [4].…”

Section: Introductionmentioning

confidence: 99%

Xanthenedione Derivatives, New Promising Antioxidant and Acetylcholinesterase Inhibitor Agents

et al. 2014

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Natural and synthetic xanthone derivatives are well-known for their ability to act as antioxidants and/or enzyme inhibitors. This paper aims to present a successful synthetic methodology towards xanthenedione derivatives and the study of their aromatization to xanthones. Additionally their ability to reduce Fe(III), to scavenge DPPH radicals and to inhibit AChE was evaluated. The results demonstrated that xanthenedione derivative 5e, bearing a catechol unit, showed higher reduction capacity than BHT and similar to quercetin, strong DPPH scavenging activity (EC 50 = 3.79 ± 0.06 µM) and it was also showed to be a potent AChEI (IC 50 = 31.0 ± 0.09 µM) when compared to galantamine (IC 50 = 211.8 ± 9.5 µM).

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“…This condition has been implicated in the pathogenesis of many diseases [12][13][14][15][16]. The current study evaluates the relationship between DNA damage, in terms of strand breaks, and antioxidant mechanisms, in terms of GSH, GPx and SOD, in patients with Graves' disease.…”

Section: Open Accessmentioning

confidence: 99%

Evaluation of Leukocyte DNA Damage and Antioxidant Defense in Graves’ Disease; Effect of Medical Treatment

Akçay¹,

Erdem²,

S³

2017

IJCPT

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IntroductionGraves' disease is the most common cause of hyperthyroidism [1]. It is characterized by palpitations, fatigue, heat intolerance, weight loss, and sometimes dermopathy and ophthalmopathy manifests through the progression of the disease [2]. Thyroid hormones increase oxidative metabolism by affecting basal metabolic rate and several mitochondrial enzymes [3,4], and hyperthyroidism causes changes in the antioxidant systems in various tissues by increasing the production of free radicals [5]. These radicals induce a variety of lesions in DNA, including DNA strand breaks, oxidized bases, and formation of cross-links between DNA and proteins [6]. DNA damage is constantly fixed by repair mechanisms in aerobic organisms; however, if cell division occurs before repairs are completed, the DNA damage becomes permanent [7]. A major site of radical attack is at the 8th position of guanine to yield 8-hydroxy-2-deoxyguanosine (8-OHdG). This modification might cause severe mutations [8], and sites within DNA which contain these alterations are more susceptible to strand breaks. These lesions can be detected by employing single cell gel electrophoresis, also known as comet assay. Furthermore, utilizing formamidopyrimidine DNA glycosylase (FPG), a damage specificrepair endonuclease, during this assay will cause additional strand breaks at sites with oxidized bases [9].Several antioxidant defense mechanisms exist in order to counter the harmful effects of free radicals. One of these defense agents is glutathione [10]. Glutathione, in its reduced form (GSH), is a physiological component of the intracellular antioxidant mechanisms. It acts against the effects of free radicals through serving as a cofactor for the enzyme glutathione peroxidase (GPx) [11]. Beside GPx, superoxide dismutase (SOD) is another enzyme deAbstract Background: Oxidative stress has been implicated in many pathological conditions, including hyperthyroidism. In this study, our aim was to investigate the effect of medical treatment on oxidative/antioxidative status and subsequent DNA damage in Graves' disease, in terms of reduced glutathione (GSH) levels, superoxide dismutase (SOD), glutathione peroxidase (GPx) activity and DNA strand breaks. Methods: Fifty female patients suffering from Graves' disease and thirty-seven healthy female controls were recruited in the study. Blood samples were taken from the patients before and after treatment. Free T3, free T4 and thyroid stimulating hormone (TSH) levels were determined using chemiluminescent particle assay, GSH, SOD and GPx activity using photometric techniques, and comet assay was utilized to analyze strand breaks with formamidopyrimidine DNA glycosylase (FPG) sensitive sites. Results: Free T3, free T4, GPx activity, DNA strand breaks and FPG sensitive sites were significantly higher, and TSH and GSH levels were significantly lower in patients prior to treatment compared to healthy controls. Following treatment, the levels of free T3, free T4 and TSH were restored to those of healthy controls, but the ...

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Role of oxidative stress in infectious diseases. A review

Cited by 126 publications

References 122 publications

Freund´s complete adjuvant effect on BALB/c mice: an insight into inflammation and oxidative stress after immunity challenge

Freund´s complete adjuvant effect on BALB/c mice: an insight into inflammation and oxidative stress after immunity challenge

Xanthenedione Derivatives, New Promising Antioxidant and Acetylcholinesterase Inhibitor Agents

Evaluation of Leukocyte DNA Damage and Antioxidant Defense in Graves’ Disease; Effect of Medical Treatment

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