Role of oxidative stress in the development of complications in patients with diabetes mellitus

Bykov, Jury

doi:10.14300/mnnc.2022.17080

Medical news of the North Caucasus

2022

DOI: 10.14300/mnnc.2022.17080

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Role of oxidative stress in the development of complications in patients with diabetes mellitus

Jury Bykov¹

Abstract: reviews ОБЗОРы contractile properties of the human diaphragm following standardized magnetic stimulation. ERJ Open Research.

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2024

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Cited by 3 publications

References 47 publications

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Oxidative stress prevention as an effective preventive strategy in type 2 diabetes mellitus

Bykov

2024

Rus. J. Prev. Med. Pub. Health

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Oxidative stress prevention as an effective preventive strategy in type 2 diabetes mellitus

Bykov

2024

Rus. J. Prev. Med. Pub. Health

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Superoxide dismutase and glutathione peroxidase content in children with type 1 diabetes mellitus

Bykov,

Baturin

2023

Sibirskij nauchnyj medicinskij zhurnal

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Type 1 diabetes mellitus (T1D) is one of the most frequently diagnosed chronic diseases of childhood. Oxidative stress (OS) is considered as one of the possible mechanisms of its development and complications. The aim of the study was to analyze the content of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GP) in children and adolescents with adequately controlled T1D.Material and methods. A total of 58 children were examined, including 34 children with type 1 diabetes (study group) and 24 conditionally healthy children (control group). The content of glycated hemoglobin, blood plasma glucose per day, post-prandial glucose, total protein, creatinine and urea were determined by conventional methods, as well as the level of SOD and GP in the blood serum by ELISA.Results and discussion. A significant decrease in the content of both enzymes was found in type 1 DM patients compared to conditionally healthy children. In patients with the chronic form of the disease, SOD and GP level was significantly lower than in patients with incident T1D. An inverse correlation was revealed between the antioxidant enzymes level on the one hand and age, duration of the disease, and the number of episodes with a poor glucose history on the other hand. The decrease in SOD and GP concentration was associated with an increase in glycated hemoglobin and plasma glucose level over a 24-hour period in patients with chronic type SD 1. The decrease in SOD concentrations was associated with an increase in glycated hemoglobin in patients with T1D chronic type. The discovered abnormalities indicate that decreased antioxidant enzyme level represent a manifestation of OS in patients with adequately controlled type 1 DM.Conclusions. Content of antioxidant enzymes in children with T1D provides an important criterion for the assessment of OS manifestations in this disease.

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Disruption of the dopaminergic system in the pathophysiology of diabetes mellitus

Bykov¹,

Baturin²

2023

jour

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Introduction. Diabetes mellitus (DM) is the most common endocrinopathy with a high incidence and a high number of complications.The aim of this work was to conduct an analytical literature review assessing the state of the problem of dopaminergic dysfunction in diabetes from a pathophysiological perspective.Materials and methods. Searching Cochrane Library, PubMed, eLibrary, Medscape databases and digital libraries using the search words: diabetes mellitus, dopamine, insulin, dopaminergic system, diabetic encephalopathy. A total of 66 sources were selected for the review.Results and discussion. Dopaminergic system dysfunction can be considered an important component of the pathophysiology of diabetes. Hyperactivation of dopamine (DA) production in the setting of diabetes inhibits insulin synthesis, resulting in hyperglycemia. On the other hand, hypoinsulinemia triggers activation of the dopaminergic system, forming a vicious circle. Increased DA production in diabetes plays an important role in the development of secondary central nervous system dysfunction, primarily through the development of cerebral insufficiency. Numerous preclinical studies confirm the dysfunction of the dopaminergic system (its activation) in diabetes. Clinical studies on this issue are scarce and require further investigation.Conclusion. Dysfunction of the dopaminergic system in diabetes is an important area of research into the pathophysiology of symptomatic neurological disorders in this disease. Type 1 and type 2 diabetes are pathogenetically different diseases, and therefore impaired DA production may be due to insulin deficiency in patients with type 1 diabetes, different timing of manifestation, with hyperinsulinemia and insulin resistance in type 2 diabetes. Finding reliable methods to diagnose dysfunction of the dopaminergic system may improve understanding of the ongoing pathological processes in the neuroendocrine system in diabetes, which is important in addressing their correction in addition to pathogenetic therapy.

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Role of oxidative stress in the development of complications in patients with diabetes mellitus

Abstract: reviews ОБЗОРы contractile properties of the human diaphragm following standardized magnetic stimulation. ERJ Open Research.

Cited by 3 publications

References 47 publications

Oxidative stress prevention as an effective preventive strategy in type 2 diabetes mellitus

Oxidative stress prevention as an effective preventive strategy in type 2 diabetes mellitus

Superoxide dismutase and glutathione peroxidase content in children with type 1 diabetes mellitus

Disruption of the dopaminergic system in the pathophysiology of diabetes mellitus

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