Role of oxidative stress in preeclampsia and intrauterine growth restriction

Mert, İsmail; Oruç, Ayla Sargın; Yüksel, Serdar; Çakar, Esra; Büyükkağnıcı, Ümran; Karaer, Abdullah; Danışman, Nuri

doi:10.1111/j.1447-0756.2011.01771.x

Cited by 109 publications

(82 citation statements)

References 40 publications

(62 reference statements)

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“…The PE group, however, showed no statistically significant difference from control (Wiktor et al 2004). Other studies on the same subject showed similar conclusions, with oxidative stress levels being higher in the groups that exhibit both pathologies (Fujimaki et al 2011;Mert et al 2012). These findings suggest a correlation be-tween the severity of the deficiency in the interaction between cytotrophoblasts and the maternal spiral arteries, both representative of IUGR and PE, and the levels of oxidative stress (Wiktor et al 2004).…”

Section: Intrauterine Growth Restrictionsupporting

confidence: 71%

Section: Intrauterine Growth Restrictionmentioning

confidence: 99%

“…Despite having distinctive clinical manifestations, there is accumulating evidence that the two pathologies have a common cause: an abnormal placental implantation (Mert et al 2012). Several studies have been conducted in order to understand if the two pathologies are related (Fujimaki et al 2011;Mert et al 2012;Takagi et al 2004;Wiktor et al 2004). One study, using immunohistochemistry and Western blotting in tissue samples from normal and PE placentas, suggested that the oxidative damage was higher in placenta displaying PE together with IUGR when compared with placenta displaying PE alone (Takagi et al 2004).…”

Section: Intrauterine Growth Restrictionmentioning

confidence: 99%

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Oxidative stress in pregnancy and fertility pathologies

Pereira

Martel

2014

Cell Biol Toxicol

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Oxidative stress designates the state of imbalance between reactive oxygen species (ROS) production and antioxidant levels. In a healthy placenta, there is an increase in ROS production, due to formation of new tissues and inherent metabolism, but this is balanced by higher levels of antioxidants. However, this balance is lost in some situations, with a consequent increase in oxidative stress levels. Oxidative stress has been implicated in several placental disorders and pregnancy pathologies. The present review intends to summarize what is known about the relationship between oxidative stress and well-known pregnancy disorders.

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Section: Intrauterine Growth Restrictionsupporting

confidence: 71%

Section: Intrauterine Growth Restrictionmentioning

confidence: 99%

Section: Intrauterine Growth Restrictionmentioning

confidence: 99%

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Oxidative stress in pregnancy and fertility pathologies

Pereira

Martel

2014

Cell Biol Toxicol

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“…However, previous studies reported conflicting results of maternal serum PON and arylesterase levels in preeclampsia [15,21]. Furthermore, the reported total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values were also controversial in different studies [10,22]. Considering the results of the above-mentioned studies, we hypothesized that since preeclampsia and atherosclerotic diseases share a common pathophysiological mechanism, namely endothelial dysfunction, it may cause alterations in the perfusion of the utero-placental-fetal unit and lead to adverse perinatal outcomes.…”

Section: Introductionmentioning

confidence: 89%

“…Endothelial dysfunction results in increased systemic vascular resistance, leading to reduced perfusion in maternal systems, including the placenta [9]. Reduced perfusion aggravates placental ischemia-reperfusion injury, which is a strong stimulus for the production of reactive oxygen species (ROS) [10]. Additionally, increased generation of ROS, increased lipid peroxidation, and/or decreased antioxidant status further exacerbate endothelial dysfunction [11].…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress markers in severe preeclampsia and preeclampsia-related perinatal morbidity — preliminary report

Öztaş

Özler²,

Tokmak³

et al. 2016

Ginekol Pol

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Objectives: The aim of the study was to determine maternal serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase (PON) and arylesterase levels in severe preeclamptic pregnants and also to investigate whether these parameters are implicated in the occurence of perinatal morbidity or not. Material and methods:A case-control study was carried out including 60 pregnant women (30 with severe preeclampsia and 30 healthy controls). The optimal cut off points of oxidative stress markers for the diagnosis of severe preeclampsia and for the prediction of adverse perinatal outcomes were evaluated by receiver operating characteristic (ROC) analyses. Multivariate logistic regression analysis was used to determine if a relationship between adverse perinatal outcomes and serum oxidative stress markers was present or not.Results: TAS (OR = 37.486, 95% CI 3.535-397.519, p = 0.003), TOS (OR = 15.588, 95% CI 2.135-113.818, p = 0.007) and arylesterase (OR = 31.356, 95% CI 2.284-430.548, p = 0.01) were found to be diagnostic for preeclampsia. Statistically significant positive correlation of adverse perinatal outcomes with serum TAS, PON and arylesterase levels were determined. Besides, a significant negative correlation was found between serum TAS levels and gestational week (r = -0.342, p = 0.007) and also between serum PON levels and birthweight (r = -0.262, p = 0.043). Conclusions:Increased maternal serum TAS, TOS and arylesterase levels are significantly associated with the presence of severe preeclampsia. Furthermore, elevated maternal serum TAS, PON and arylesterase levels are significantly and positively correlated with adverse perinatal outcomes. We suggest that in preeclampsia increased oxidative status may cause adverse perinatal outcomes and antioxidants may be increased in order to protect the fetus against oxidative damage.

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The potential therapeutic effects of curcumin on pregnancy complications: Novel insights into reproductive medicine

et al. 2020

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Pregnancy complications including preeclampsia, preterm birth, intrauterine growth restriction, and gestational diabetes are the main adverse reproductive outcomes. Excessive inflammation and oxidative stress play crucial roles in the pathogenesis of pregnancy disorders. Curcumin, the main polyphenolic compound derived from Curcuma longa, is mainly known by its anti-inflammatory and antioxidant properties. There are in vitro and in vivo reports revealing the preventive and ameliorating effects of curcumin against pregnancy complications. Here, we aimed to seek mechanisms underlying the modulatory effects of curcumin on dysregulated inflammatory and oxidative responses in various pregnancy complications.

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Role of oxidative stress in preeclampsia and intrauterine growth restriction

Abstract: Increased oxidative stress and antioxidative defense mechanisms may contribute to disease processes both in preeclampsia and IUGR.

Cited by 109 publications

References 40 publications

Oxidative stress in pregnancy and fertility pathologies

Oxidative stress in pregnancy and fertility pathologies

Oxidative stress markers in severe preeclampsia and preeclampsia-related perinatal morbidity — preliminary report

The potential therapeutic effects of curcumin on pregnancy complications: Novel insights into reproductive medicine

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