Role of oxidative stress in melasma: a prospective study on serum and blood markers of oxidative stress in melasma patients

Choubey, Vikrant; Sarkar, Rashmi; Garg, Vijay Kumar; Kaushik, Smita; Ghunawat, Sneha; Sonthalia, Sidharth

doi:10.1111/ijd.13695

Cited by 36 publications

(41 citation statements)

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“…The mean age of patients at the time of presentation was 32.81 ± 6.83 years, whereas the mean age of onset based on history was 28.68 ± 6.28 years. These findings were in accordance with various previous studies . The most common pattern in our study was mixed (40%), specifically a combination of centrofacial and malar patterns, followed by centrofacial pattern (30.7%).…”

Section: Discussionsupporting

confidence: 94%

“…Furthermore, a study conducted by Choubey et al , involving 50 cases and 50 controls, showed that the serum levels of malondialdehyde, SOD, and blood GSH‐Px were significantly higher among the cases compared to controls. Additionally, the authors also found a statistically significant positive correlation between serum malondialdehyde and severity of melasma.…”

Section: Introductionmentioning

confidence: 96%

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Melatonin and oxidative stress in melasma ‒ an unexplored territory; a prospective study

et al. 2020

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Background Melasma, an acquired disorder of hyperpigmentation, is the most common pigmentary disorder in India. Many factors are implicated in the pathogenesis, and recently the role of oxidative damage including melatonin has been postulated. This study was undertaken to evaluate the role of oxidative stress and serum melatonin in pathogenesis of melasma.Methods Seventy-five patients with melasma and an equal number of age and sexmatched controls were included in the study. Clinical characteristics were noted, and baseline severity assessment using modified Melasma Area and Severity Index (MASI) was done in all patients. Serum melatonin, catalase, protein carbonyl, and nitric oxide levels were measured and compared between cases and controls. ResultsThe serum levels of melatonin and catalase were significantly lower among the cases as compared to controls, while the serum levels of protein carbonyl and nitric oxide were significantly higher in cases compared to controls. There was no statistically significant correlation between these markers of oxidative stress and severity of the disease. ConclusionsOxidative stress is increased in patients with melasma compared to the control group in this study. A state of melatonin deficit also exists in patients with melasma.No correlation between the oxidative stress and severity of the disease was found. Further and larger studies including therapeutic trials with powerful antioxidants are warranted. * P < 0.05 is statistically significant.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 96%

Melatonin and oxidative stress in melasma ‒ an unexplored territory; a prospective study

et al. 2020

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“…The melanoma models also showed that activated Akt is implicated in MM and its invasiveness, accompanied with the elevation of mTOR, peroxides and angiogenesis [54]. In addition, an available experiment on chloasma suggested that UV-induced ROS greatly elevated the activity of tyrosinase by stimulating PI3K/Akt signaling pathway, thereby facilitating the increase of melanin [55]. Hence, blockage of this pathway to some extent would be a favourable approach for above dermatoses therapy.…”

Section: Os and Pi3k/akt Signaling Pathwaymentioning

confidence: 99%

Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses

Xian

Guo

et al. 2021

Redox Report

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Background: Skin, as a crucial external defense organ, is more vulnerable to oxidative stress (OS) insult, reactive oxygen species (ROS)-mediated OS in particular. OS results from a redox imbalance caused by various extrinsic stimuli and occurs once the oxidants production overwhelming the antioxidants capacity, through mediating in DNA damage, lipid peroxidation (LPO), protein oxidation and a serial of signaling pathways activation/inactivation, thereby offering favorable conditions for the occurrence and development of numerous diseases especially some dermatoses, e.g. psoriasis, vitiligo, skin photodamage, skin cancer, systemic sclerosis (SSc), chloasma, atopic dermatitis (AD), pemphigus, etc. Targeting OS molecular mechanism, a variety of anti-OS agents emerge, in which flavonoids, natural plant extracts, stand out. Objectives: To discuss the possible mechanisms of OS mediating in dermatoses and summarize the properties of flavonoids as well as their applications in OS-related skin disorders. Methods: Published papers on flavonoids and OS-related skin diseases were collected and reviewed via database searching on PubMed, MEDLINE and Embase, etc. Results: It has been confirmed that flavonoids, belonging to polyphenols, are a class of plant secondary metabolites widely distributed in various plants and possess diverse bioactivities especially their potent antioxidant capacity. Moreover, flavonoids benefit to suppress OS via eliminating free radicals and mediating the corresponding signals, further excellently working in the prevention and management of OS-related skin diseases. Conclusion: Flavonoids have the potential therapeutic effects on oxidative stress-related dermatoses. However, more studies on specific mechanism as well as the dosage of flavonoids are needed in future.

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“…Malondialdehyde, the end-product of lipid peroxidase, can also be used to assess tissue damage due to ROS. Previous research tested the levels of these enzymes on patients with facial melasma and concluded that the levels of superoxide dismutase, catalase, glutathione peroxidase were significantly higher in melasma patients as compared to control patients (p<0.001), concluding that oxidative stress plays a role in the pathogenesis of melasma [ 11 , 12 ].…”

Section: Reviewmentioning

confidence: 99%

Melasma: A Condition of Asian Skin

Wu¹,

R²,

Mayrovitz³

2021

Cureus

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Role of oxidative stress in melasma: a prospective study on serum and blood markers of oxidative stress in melasma patients

Abstract: Oxidative stress was found to be increased in cases of melasma compared to the control group in this study. This substantiates the role of oxidative stress in etiopathogenesis of melasma; however, further studies are required to reach a definitive conclusion.

Cited by 36 publications

References 30 publications

Melatonin and oxidative stress in melasma ‒ an unexplored territory; a prospective study

Melatonin and oxidative stress in melasma ‒ an unexplored territory; a prospective study

Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses

Melasma: A Condition of Asian Skin

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