Role of oxidative stress in advanced glycation end product-induced mesangial cell activation

Lal, Mark; Brismar, Hjalmar; Eklöf, Ann-Christine; Aperia, Anita

doi:10.1046/j.1523-1755.2002.00367.x

Cited by 124 publications

(89 citation statements)

References 37 publications

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“…The degree of ECM accumulation has been found to correlate with the extent of renal insufficiency and proteinuria (16), and MCs are recognized as being the major cells in the secretion ECM (11,12). Therefore, the inhibition of MC proliferation and ECM accumulation should be beneficial in DN.…”

Section: Discussionmentioning

confidence: 99%

“…Among these factors, transforming growth factor (TGF)-β 1 and its downstream mediator connective tissue growth factor (CTGF) are recognized as fibrogenic cytokines and play a critical role in the kidney pathophysiology of DN (9,10). Mesangial cells (MCs) are recognized as the major ECM-secreting cells (11,12). The inhibition of MC proliferation and ECM accumulation should be beneficial in DN.…”

Section: Introductionmentioning

confidence: 99%

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Effects of astragalosides from Radix Astragali on high glucose-induced proliferation and extracellular matrix accumulation in glomerular mesangial cells

Chen

Wang

Tong

et al. 2016

Experimental and Therapeutic Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of astragalosides from Radix Astragali on high glucose-induced proliferation and extracellular matrix accumulation in glomerular mesangial cells

Chen

Wang

Tong

et al. 2016

Experimental and Therapeutic Medicine

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“…The Pro198Leu polymorphisms can significantly influence the levels and activity of most common antioxidant enzymes, which can lead to reduced protection against oxidative stress [17,18,19,20,21].…”

Section: Introductionmentioning

confidence: 99%

The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

Malinowska¹,

Kowalski²,

Szaflik³

et al. 2016

pjp

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The development of glaucoma may be connected with a long-term exposure to oxidative stress caused by free radical (ROS). The main aim of this work was an analysis of associations of Cat-262C/T, GPX1 Pro198Leu and SOD1 35 A/C gene polymorphisms of antioxidant enzymes with a risk of open-angle glaucoma (POAG) in a Polish population. DNA samples collected from 209 patients with POAG and 191 healthy controls were used in this study. Polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). We found that the +35A/C polymorphisms of SOD1 were not associated with a risk of POAG. We found that C/T genotype (1-GPX1Pro198Leu, 2-Cat C262T) is associated with increased risk of open angle glaucoma (1-OR = 2.24; 95% CI: 1.46-3.44; p = 0.0001, 2-OR = 2.16; 95% CI: 1.35-3.34; p = 0.001). We also found that T/T genotype is a risk factor for progression of POAG (1-OR = 3.86; 95% Cl: 1.36-10.96; p = 0.007, 2-OR = 6.37; 95% CI: 1.39-29.28; p = 0.007). Finally our data suggest that gene polymorphisms of GPX1 Pro198Leu and CAT C262T may have a protective role in the development of primary open-angle glaucoma in a Polish population.

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“…First, immunological studies using an anti-AGE antibody demonstrated the accumulation of AGE in glomerular mesangial lesions of diabetic nephropathy [8,9]. Second, AGE proteins prepared by the modification of BSA with ribose, induced TGF-β synthesis at an mRNA level in rat mesangial cells [10]. Third, AGE proteins prepared by incubating BSA with glucose-6-phosphate increased the levels of growth factors such as TGF-β and IGF-I and extracellular matrix proteins such as fibronectin, laminin and type IV collagen at the protein level in rat mesangial cells [11,12].…”

Section: Introductionmentioning

confidence: 99%

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

et al. 2005

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Aims/hypothesis: Glomerular mesangial expansion is a characteristic feature of diabetic nephropathy, and the accumulation of AGE in the mesangial lesion has been implicated as one of its potential causes. However, the route for the AGE accumulation in mesangial lesions in diabetic patients is poorly established. Methods: Glycolaldehyde-modified BSA (GA-BSA) and methylglyoxalmodified BSA (MG-BSA) were prepared as model AGE proteins, and their in vivo plasma clearance was examined in mice, and renal uptake by in vitro studies with isolated renal mesangial cells. Results: Both 111 In-GA-BSA and 111

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Role of oxidative stress in advanced glycation end product-induced mesangial cell activation

Abstract: The results support a central role for oxidative stress in AGE-dependent mesangial cell signaling and emphasize the importance of ROS in determining cell responsiveness.

Cited by 124 publications

References 37 publications

Effects of astragalosides from Radix Astragali on high glucose-induced proliferation and extracellular matrix accumulation in glomerular mesangial cells

Effects of astragalosides from Radix Astragali on high glucose-induced proliferation and extracellular matrix accumulation in glomerular mesangial cells

The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

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