Role of osteopontin in the pathophysiology of cancer

Shevde, Lalita A.; Samant, Rajeev S.

doi:10.1016/j.matbio.2014.03.001

Cited by 219 publications

(202 citation statements)

References 159 publications

Supporting

Mentioning

181

Contrasting

Unclassified

Order By: Relevance

“…There is increasing knowledge that extracellular OPN (eOPN) binds to its main receptors, integrins and CD44, activating their corresponding signalling pathways and mediating different OPN functions in cancer cells (40). However, other reports have also described iOPN, both in the cytoplasm and in the nucleus, in distinct cell contexts (41,42).…”

Section: Discussionmentioning

confidence: 99%

Osteopontin expression is correlated with differentiation and good prognosis in medullary thyroid carcinoma

Ferreira¹,

Eloy²,

Pestana³

et al. 2016

European Journal of Endocrinology

View full text Add to dashboard Cite

Background: Osteopontin (OPN) or secreted phosphoprotein 1 (SPP1) is a matricellular glycoprotein whose expression is elevated in various types of cancer and has been shown to be involved in tumourigenesis and metastasis in many malignancies, including follicular cell-derived thyroid carcinomas. Its role in C-cell-derived thyroid lesions and tumours remains to be established. Objective: The objective of this study is to clarify the role of OPN expression in the development of medullary thyroid carcinoma (MTC). Methods: OPN expression was analysed in a series of 116 MTCs by immunohistochemistry and by qPCR mRNA quantification of the 3 OPN isoforms (OPNa, OPNb and OPNc) in six cases from which fresh frozen tissue was available. Statistical tests were used to evaluate the relationship of OPN expression and the clinicopathological and molecular characteristics of patients and tumours. Results: OPN expression was detected in 91 of 116 (78.4%) of the MTC. We also observed high OPN expression in C-cell hyperplasia as well as in C-cells scattered in the thyroid parenchyma adjacent to the tumours. OPN expression was significantly associated with smaller tumour size, PTEN nuclear expression and RAS status, and suggestively associated with non-invasive tumours. OPNa isoform was expressed significantly at higher levels in tumours than in non-tumour samples. OPNb and OPNc presented similar levels of expression in all samples. Furthermore, OPNa isoform overexpression was significantly associated with reduced growth and viability in the MTC-derived cell line (TT). Conclusion: The expression of OPN in normal C-cells and C-cell hyperplasia suggests that OPN is a differentiation marker of C-cells, rather than a marker of biological aggressiveness in this setting. At variance with other cancers, OPN expression is associated with good prognostic features in MTC.

show abstract

Section: Discussionmentioning

confidence: 99%

Osteopontin expression is correlated with differentiation and good prognosis in medullary thyroid carcinoma

Ferreira¹,

Eloy²,

Pestana³

et al. 2016

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Dysregulation of matricellular protein expression is also a common feature in cancer and has been linked to risk for carcinogenesis, malignant progression, and metastatic disease (88,174,236,247,250). Although correlations have been clearly established with altered redox signaling, a causal relationship between aberrant matricellular protein expression and impaired redox homeostasis in cancer remains largely unknown.…”

Section: Discussionmentioning

confidence: 99%

Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer

Roberts

Kaur

Isenberg

2017

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

Significance: In contrast to structural elements of the extracellular matrix, matricellular proteins appear transiently during development and injury responses, but their sustained expression can contribute to chronic disease. Through interactions with other matrix components and specific cell surface receptors, matricellular proteins regulate multiple signaling pathways, including those mediated by reactive oxygen and nitrogen species and H 2 S. Dysregulation of matricellular proteins contributes to the pathogenesis of vascular diseases and cancer. Defining the molecular mechanisms and receptors involved is revealing new therapeutic opportunities. Recent Advances: Thrombospondin-1 (TSP1) regulates NO, H 2 S, and superoxide production and signaling in several cell types. The TSP1 receptor CD47 plays a central role in inhibition of NO signaling, but other TSP1 receptors also modulate redox signaling. The matricellular protein CCN1 engages some of the same receptors to regulate redox signaling, and ADAMTS1 regulates NO signaling in Marfan syndrome. In addition to mediating matricellular protein signaling, redox signaling is emerging as an important pathway that controls the expression of several matricellular proteins. Critical Issues: Redox signaling remains unexplored for many matricellular proteins. Their interactions with multiple cellular receptors remains an obstacle to defining signaling mechanisms, but improved transgenic models could overcome this barrier. Future Directions: Therapeutics targeting the TSP1 receptor CD47 may have beneficial effects for treating cardiovascular disease and cancer and have recently entered clinical trials. Biomarkers are needed to assess their effects on redox signaling in patients and to evaluate how these contribute to their therapeutic efficacy and potential side effects. Antioxid. Redox Signal. 27, 874-911.

show abstract

“…Due to the fact that OPN is involved in the regulation of many cellular functions, alteration of OPN function is implicated in cancer pathology [38]. Cancer development results from the transformation of normal cells into cancer cells.…”

Section: Osteopontin and Inflammationmentioning

confidence: 99%

“…Because OPN is an agent exerting pleiotropic properties in the regulation of cellular functions, the protein is also regarded to be involved in the pathophysiology of cancer. OPN abnormalities were discovered in multiple malignancies, both at the stages of initiation, promotion and progression of a tumour [38].…”

Section: Osteopontin and Inflammationmentioning

confidence: 99%

Physiological and pathophysiological implications of osteopontin and the diagnostic utility of the protein in kidney diseases

Dobrek¹

2018

J Pre Clin Clin Res.

View full text Add to dashboard Cite

Introduction and objective. Osteopontin (OPN) is a protein playing many pleiotropic both physiological and pathophysiological roles in various organs. The paper briefly characterizes both the positive and negative roles of OPN, with particular emphasis on the role of the protein in kidney functioning. Brief description of the state of knowledge. As its name suggests, OPN is a protein mainly regulating bone homeostasis, but it also participates in the pathogenesis of inflammation, neoplasm, atherosclerosis and vascular calcification. OPN is also an important protein involved in kidney physiology. Its main physiological function is to act as an inhibitor of the crystallization of urine mineral components and to prevent kidney stones formation. OPN is also overproduced in various kidney pathologies (tubulointerstitial fibrosis, crescending glomerulonephritis, cyclosporine or diabetic nephropathy, renal ischemia reperfusion injury), and both experimental and clinical studies suggest that OPN may exert either a protective or detrimental effect on kidneys. Conclusions. Considering the OPN role in kidneys, the protein is currently proposed as one of novel laboratory biomarkers for renal function. OPN, along with the other proteins found in the urine in various kidney diseases (neutrophil gelatinaseassociated lipocalin-1, kidney injury molecule-1, and fatty acid binding protein) is a part of the laboratory panel that will be gradually introduced into common laboratory practice.

show abstract

Role of osteopontin in the pathophysiology of cancer

Cited by 219 publications

References 159 publications

Osteopontin expression is correlated with differentiation and good prognosis in medullary thyroid carcinoma

Osteopontin expression is correlated with differentiation and good prognosis in medullary thyroid carcinoma

Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer

Physiological and pathophysiological implications of osteopontin and the diagnostic utility of the protein in kidney diseases

Contact Info

Product

Resources

About