Role of oral microbiome in oral oncogenesis, tumor progression, and metastasis

Li, Ruohan; Li, Xiao; Gong, Tao; Liu, Jiaxin; Li, Yuqing; Li, Yang; Zheng, Xin

doi:10.1111/omi.12403

Cited by 21 publications

(18 citation statements)

References 185 publications

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“…81 Similarly, the oral cavity also harbours a vast collection of bacteria, viruses, and fungi and any irregularity in the normal oral microbiome has been associated with aggravating oral cancer progression. 82 A few bacterial competitions are identified in HPV-related tumours as well, where the microbial interactions among themselves are not always detrimental to the host and certain specific interactions may also help in the clearance of the infection. Candida vaginitis, a fungal species residing as part of the normal flora in the cervicovaginal region, is a perfect example for this kind of interaction.…”

Section: Beneficial Co-existing Microbes For Human Papillomavirus Cle...mentioning

confidence: 99%

“…A dysregulated expression of the aforementioned facets can indicate BV in cervicovaginal region 81 . Similarly, the oral cavity also harbours a vast collection of bacteria, viruses, and fungi and any irregularity in the normal oral microbiome has been associated with aggravating oral cancer progression 82 …”

Section: Beneficial Co‐existing Microbes For Human Papillomavirus Cle...mentioning

confidence: 99%

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Coinfections in human papillomavirus associated cancers and prophylactic recommendations

Ashok,

Basu,

Priyamvada

et al. 2024

Reviews in Medical Virology

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The Human Papillomavirus (HPV) infection is responsible for more than 80% of reported cervical cancer and other virus‐associated tumours. Although this global threat can be controlled using effective vaccination strategies, a growing perturbation of HPV infection is an emerging coinfection likely to increase the severity of the infection in humans. Moreover, these coinfections prolong the HPV infections, thereby risking the chances for oncogenic progression. The present review consolidated the clinically significant microbial coinfections/co‐presence associated with HPV and their underlying molecular mechanisms. We discussed the gaps and concerns associated with demography, present vaccination strategies, and other prophylactic limitations. We concluded our review by highlighting the potential clinical as well as emerging computational intervention measures to kerb down HPV‐associated severities.

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Section: Beneficial Co-existing Microbes For Human Papillomavirus Cle...mentioning

confidence: 99%

Section: Beneficial Co‐existing Microbes For Human Papillomavirus Cle...mentioning

confidence: 99%

Coinfections in human papillomavirus associated cancers and prophylactic recommendations

Ashok,

Basu,

Priyamvada

et al. 2024

Reviews in Medical Virology

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“…Consequently, there is increasing awareness of the crucial role of periodontopathogenic bacteria in oral squamous cell carcinoma. Li et al reported that P. gingivalis , F. nucleatum , and T. denticola could stimulate oral squamous cell carcinoma (OSCC) by promoting epithelial cell proliferation, inhibiting apoptosis, and modulating the inflammatory microenvironment [ 124 ]. Microbial dysbiosis may serve as a bridge between periodontal diseases and oral cancer [ 125 ], and the next question is whether viruses are involved in the progression.…”

Section: Phage Vaccines: An Option For Oral Cancer Controlmentioning

confidence: 99%

A review and new perspective on oral bacteriophages: manifestations in the ecology of oral diseases

Guo,

Wang,

Shi

et al. 2024

Journal of Oral Microbiology

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Objective To explore the manifestations of bacteriophages in different oral disease ecologies, including periodontal diseases, dental caries, endodontic infections, and oral cancer, as well as to propel phage therapy for safer and more effective clinical application in the field of dentistry. Methods In this literature review, we outlined interactions between bacteriophages, bacteria and even oral cells in the oral ecosystem, especially in disease states. We also analyzed the current status and future prospects of phage therapy in the perspective of different oral diseases. Results Various oral bacteriophages targeting at periodontal pathogens as Porphyromonas gingivalis , Fusobacterium nucleatum , Treponema denticola and Aggregatibacter actinomycetemcomitans , cariogenic pathogen Streptococcus mutans , endodontic pathogen Enterococcus faecalis were predicted or isolated, providing promising options for phage therapy. In the realm of oral cancer, aside from displaying tumor antigens or participating in tumor-targeted therapies, phage-like particle vaccines demonstrated the potential to prevent oral infections caused by human papillomaviruses (HPVs) associated with head-and-neck cancers. Conclusion Due to their intricate interactions with bacteria and oral cells, bacteriophages are closely linked to the progression and regression of diverse oral diseases. And there is an urgent need for research to explore additional possibilities of bacteriophages in the management of oral diseases.

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“…Therefore, a standardized technique is needed in the future to regulate sampling procedures. Chronic infection is considered a risk factor in the development of cancer [ 81 ]. Evidence suggests that periodontal pathogens, such as Porphyromonas gingivalis , Fusobacterium nucleatum , and Treponema denticola , are associated with OSCC [ 81 ].…”

Section: The Role Of Oral and Vaginal Microbiota In Viral Oncogenesismentioning

confidence: 99%

“…Chronic infection is considered a risk factor in the development of cancer [ 81 ]. Evidence suggests that periodontal pathogens, such as Porphyromonas gingivalis , Fusobacterium nucleatum , and Treponema denticola , are associated with OSCC [ 81 ]. They can stimulate tumorigenesis by promoting epithelial cell proliferation while inhibiting apoptosis and regulating the inflammatory microenvironment.…”

Section: The Role Of Oral and Vaginal Microbiota In Viral Oncogenesismentioning

confidence: 99%

Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature

Dellino,

Pinto,

D’Amato

et al. 2024

JCM

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Human genital papilloma virus infection is the most prevalent sexually transmitted infection in the world. It is estimated that more than 75% of sexually active women contract this infection in their lifetime. In 80% of young women, there is the clearance of the virus within 18–24 months. In developed countries, oral squamous cell carcinoma (OSCC) is now the most frequent human papilloma virus (HPV)-related cancer, having surpassed cervical cancer, and it is predicted that by 2030 most squamous cell carcinomas will be the HPV-related rather than non-HPV-related form. However, there are currently no screening programs for oral cavity infection. While the natural history of HPV infection in the cervix is well known, in the oropharynx, it is not entirely clear. Furthermore, the prevalence of HPV in the oropharynx is unknown. Published studies have found wide-ranging prevalence estimates of 2.6% to 50%. There are also conflicting results regarding the percentage of women presenting the same type of HPV at two mucosal sites, ranging from 0 to 60%. Additionally, the question arises as to whether oral infection can develop from genital HPV infection, through oral and genital contact or by self-inoculation, or whether it should be considered an independent event. However, there is still no consensus on these topics, nor on the relationship between genital and oral HPV infections. Therefore, this literature review aims to evaluate whether there is evidence of a connection between oral and cervical HPV, while also endorsing the usefulness of the screening of oral infection in patients with high-risk cervical HPV as a means of facilitating the diagnosis and early management of HPV-related oral lesions. Finally, this review emphasizes the recommendation for the use of the HPV vaccines in primary prevention in the male and female population as the most effective means of successfully counteracting the increasing incidence of OSCC to date.

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Role of oral microbiome in oral oncogenesis, tumor progression, and metastasis

Cited by 21 publications

References 185 publications

Coinfections in human papillomavirus associated cancers and prophylactic recommendations

Coinfections in human papillomavirus associated cancers and prophylactic recommendations

A review and new perspective on oral bacteriophages: manifestations in the ecology of oral diseases

Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature

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