Role of Oral Enzymes in Post Operative Septoplasty Cases

Nanda, Manpreet Singh; Kaur, Mandeep

doi:10.1007/s12070-014-0814-3

Cited by 7 publications

(6 citation statements)

References 8 publications

(10 reference statements)

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“…The usual use of postoperative packing following septoplasty should be questioned due to a lack of data to demonstrate a favorable benefit and the potential for adverse side effects. Risk factors are:  Toxic shock syndrome [25]  Formation of synechiae [25]  A septal hematoma [25]  Pain [25] Nanda MS and Kaur M's [26] research concluded that in comparison to other current medicines such as NSAIDs, oral enzymes are extremely effective in managing post-operative inflammation and infection. When oral enzymes are given after surgery, patient satisfaction is substantially higher.…”

Section: Post Operationmentioning

confidence: 99%

Study on Septal Correction: Review of Literature and Clinical Findings

Bomanwar

Singh

2021

JPRI

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Septal reconstruction has many needs and usages. Nowadays, people are very concerned about looking and would like to correct them. Septal reconstruction has been immensely used in the field of cosmetics. A successful septoplasty would lead us to know about the pathology of the septum by which we can avoid further complications. It would be further significant in nasal obstruction or difficulty in breathing. Deviation of the nasal septum can also be corrected by septal reconstruction by various techniques used for septoplasty. Complete septal reconstruction is the best method for extreme S-shaped and wave-like deviations or multiple fractures. The septoplasty is performed endonasal for caudal septal deviation. Traction sutures to rectify the caudal septum deviation is another type of surgery. Septoplasty usually opens the way for all other rhinoplasty procedures, as a straight, stable septum reflects the attractiveness and functionality of the nose. The patient's history and the surgeon's expertise play a favorable outcome. In conjunction with other nose procedures, such as cosmetic rhinoplasty and endoscopic sinus surgery, Septoplasty is frequently done to alleviate nasal airway obstruction or headaches induced by rhinology irritation produced by touch. Endoscopic septoplasty requires the same amount of time and delivers equal, if not better, results than previous procedures. Visualization is vastly improved by endoscopic technology. Isolated deviation, spurs, perforations, and contact sites are examples of distinct septal disorders that can be treated individually using this procedure. In this review article, the importance of traction sutures is mentioned. The article gives us an idea about Septoplasty and how it can be achieved, its complications, risk factors, and a few postoperative points.

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Section: Post Operationmentioning

confidence: 99%

Study on Septal Correction: Review of Literature and Clinical Findings

Bomanwar

Singh

2021

JPRI

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“…6 A potential worthwhile option for alleviating postoperative pain and reducing NSAID consumption is the use of oral enzyme combinations (OECs). The effect of OECs constituting proteases, such as bromelain (a proteolytic enzyme) and other ingredients like rutoside (a glycoside combining the flavonol quercetin and the disaccharide rutinose) on reducing pain, oedema and inflammation, has been demonstrated in animal models, 17,18 in experimentally induced skin biopsies 19 or haematomas, 20 after septoplasty, 21,22 orthognathic surgery 23 and dental surgery. [24][25][26] However, there is limited evidence of the effect of systemic enzyme therapy in patients undergoing orthopaedic surgery.…”

Section: Introductionmentioning

confidence: 99%

Oral enzyme combination with bromelain, trypsin and the flavonoid rutoside reduces systemic inflammation and pain when used pre- and post-operatively in elective total hip replacement: a randomized exploratory placebo-controlled trial

Vosáhlo,

Salus,

Smolko

et al. 2023

Therapeutic Advances in Musculoskeletal

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Background: Early mobilization after total hip replacement (THR) is key for fast recovery but is often limited by pain. Oral enzyme combinations (OECs) have demonstrated anti-inflammatory and pain-relieving effects. Objectives and design: This prospective, randomized, double-blind, placebo-controlled exploratory trial evaluated the effects of pre- and post-operative use of OEC (90 mg bromelain, 48 mg trypsin, 100 mg rutoside) following elective THR, on post-operative recovery. Methods: Candidates for primary elective cementless THR owing to osteoarthritis were eligible for participation [age ⩾50 years, body mass index 25–35 kg/m2, C-reactive protein (CRP) ⩽6 mg/L]. Following randomization to OEC or placebo, intervention started pre-operatively and continued onwards until day 42. Main outcomes included post-operative CRP levels (days 1–7), self-reported hip pain at rest (by 0–10 cm visual analogue scale on post-operative days 1–42), post-operative analgesic use [by cumulative analgesic consumption score (CACS) days 7–42], tolerability and adverse events. Results: Patients ( N = 34) were recruited from a tertiary orthopaedic hospital in the Czech Republic, of whom 33 completed the study (OEC/placebo: n = 15/18). Baseline characteristics across the groups were comparable. Compared with placebo, the OEC group had numerically lower CRP levels on post-operative days 1–7, including peak level [mean (standard deviation) OEC versus placebo: 81.4 (28.3) versus 106.7 (63.3) mg/L], which translated into a significant 32% lower CRP area under the curve ( p = 0.034). The OEC group reported significantly less pain during post-operative days 1–7 versus placebo (analysis of variance treatment × visit [ F(4) = 3.989]; p = 0.005). Analgesic use was numerically reduced as assessed through an accumulated CACS. No deleterious effects on haemorheological parameters were observed in either group. Conclusions: Pre- and post-operative use of OEC significantly reduced CRP levels and patient self-reported pain. OEC may be an efficacious and safe treatment option to facilitate post-operative recovery following THR. Trial registration: EudraCT number 2016-003078-41

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“…This is based on evidence, gathered over the decades, from multiple 1 M. V. Hospital and Research Centre, Lucknow, Uttar Pradesh, India 2 SIRO Clinpharm Ltd., Thane, Maharashtra, India studies in myriad inflammatory conditions. [2][3][4][5][6][7][8][9][10] This study was conducted to evaluate the efficacy and safety of an enzyme-bioflavonoid combination of trypsin-bromelainrutoside in managing the post-operative inflammation in patients undergoing dental surgeries.…”

Section: Introductionmentioning

confidence: 99%

Management of post-operative wound in dental surgeries using proteolytic enzyme-flavonoid combination of trypsin, bromelain and rutoside: a single-centre experience

Tiwari

Khemnar²,

John³

2022

Int J Res Med Sci

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Background: Appropriate surgical wound management is required to prevent post-operative complications, including delayed wound-healing which may result in increased hospital stay. The present study aimed to evaluate the efficacy and safety of oral administration of a fixed dose combination of trypsin-bromelain-rutoside in the post-operative management after dental surgeries.Methods: The study was a prospective, observational data collection exercise. Hundred subjects undergoing dental surgeries, who were administered trypsin-bromelain-rutoside combination, were observed over a period of 8 days post-surgery. Verbal rating scales were used for grading the pain intensity and extent of swelling, while a 5-point Likert scale was used to evaluate patient- and investigator-reported global assessment of improvement in pain and swelling. Scores at day 3 and day 8 were analysed using paired t test.Results: At day 3 and day 8, the mean scores of pain and swelling were significantly reduced from baseline (all p<0.0001). By day 8, 100% of the patients achieved complete resolution of pain, while mild swelling was reported in only 2 patients. At day 3, 95% patients reported good/ very good global improvement in pain and swelling; while at day 8, 100% reported good/ very good improvement. No adverse event was reported in any of the patients.Conclusions: The study results demonstrate that treatment with trypsin-bromelain-rutoside combination led to significant improvement in the post-operative pain and swelling. The use of this combination is useful for wound recovery and reducing the need for other analgesic and anti-inflammatory drugs.

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Role of Oral Enzymes in Post Operative Septoplasty Cases

Cited by 7 publications

References 8 publications

Study on Septal Correction: Review of Literature and Clinical Findings

Study on Septal Correction: Review of Literature and Clinical Findings

Oral enzyme combination with bromelain, trypsin and the flavonoid rutoside reduces systemic inflammation and pain when used pre- and post-operatively in elective total hip replacement: a randomized exploratory placebo-controlled trial

Management of post-operative wound in dental surgeries using proteolytic enzyme-flavonoid combination of trypsin, bromelain and rutoside: a single-centre experience

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