Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress

Qi, Wen; Yi, Heqing; Yang, Ke; Yin, Changtian; Yin, Wenjuan; Xiang, Fang-Yue; Bao, Miao; Jing, Shuai; Song, Yiwei; Ge, Minghua; Zhu, Xin

doi:10.1016/j.mce.2020.111144

Cited by 9 publications

(9 citation statements)

References 27 publications

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“…The human PTC cell line TPC‐1 was kindly provided by Dr. Xin Zhu 17 (Zhejiang Cancer Hospital). To verify the authenticity of TPC‐1 cell lines, DNA short tandem repeat (STR) analysis was performed by Biowing.…”

Section: Methodsmentioning

confidence: 99%

Identification of prognostic biomarkers for papillary thyroid carcinoma by a weighted gene co‐expression network analysis

Meng

Zheng

et al. 2022

Cancer Medicine

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Aim Whole transcriptome analysis was conducted to identify differentially expressed RNAs and regulatory networks associated with papillary thyroid carcinoma (PTC). Methods A weighted gene co‐expression network analysis based on high‐throughput sequencing data for six pairs of PTC and adjacent tissue samples was conducted to understand the biological functions and regulatory networks involving long non‐coding RNAs (lncRNAs), circular RNAs (circRNAs), microRNAs (miRNAs), and messenger RNAs (mRNAs). Results We detected 131, 338, 31, and 556 differentially expressed circRNAs, lncRNAs, miRNAs, and mRNAs, respectively. We identified modules that were significantly positively and negatively related to cancer and lymph node metastasis. Gray and turquoise modules were positively correlated with cancer phenotypes (p < 0.05), whereas yellow, brown, and blue modules were negatively correlated with cancer (p < 0.05). Gray module was positively correlated with lateral lymph node metastasis (p = 0.02). Kaplan–Meier analyses revealed that the levels of transmembrane protein 63C (TMEM63C), lysyl oxidase‐like 1 (LOXL1), collagen type V alpha 1 chain (COL5A1), ADAM metalloproteinase with thrombospondin type I motif 2 (ADAMTS2), and LysM‐domain containing 3 (LYSMD3) were significantly associated with overall survival (p < 0.05). Significant increase in the expression of COL5A1 and LOXL1 in tumor tissues was validated by quantitative real‐time polymerase chain reaction (p < 0.05). COL5A1 and LOXL1 promoted PTC cell growth and invasion in vitro. Conclusions We identified COL5A1 and LOXL1 as potential prognostic biomarkers, providing new insights into the occurrence and progression of PTC.

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Section: Methodsmentioning

confidence: 99%

Identification of prognostic biomarkers for papillary thyroid carcinoma by a weighted gene co‐expression network analysis

Meng

Zheng

et al. 2022

Cancer Medicine

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“…Thus, fine-tuning ROS levels in an already pro-oxidant environment might be critical for cancer cell survival. It has been demonstrated that the PIM-1 kinase increases the protein expression of the antioxidants GPX1 and SOD2 in thyroid cancer cells, whereas its inactivation increases ROS [ 75 ]. Interestingly, the increased expression of GPX1 and SOD2 and augmented GPX and SOD activities have been reported in thyroid cancer when compared with normal tissue [ 48 , 75 , 76 , 77 ].…”

Section: Redox Homeostasis In the Thyroid Glandmentioning

confidence: 99%

“…It has been demonstrated that the PIM-1 kinase increases the protein expression of the antioxidants GPX1 and SOD2 in thyroid cancer cells, whereas its inactivation increases ROS [ 75 ]. Interestingly, the increased expression of GPX1 and SOD2 and augmented GPX and SOD activities have been reported in thyroid cancer when compared with normal tissue [ 48 , 75 , 76 , 77 ]. The expression of PIM-1 is overexpressed in PTCs and positively correlated with NOX4, GPX1, and SOD2 expression [ 75 ].…”

Section: Redox Homeostasis In the Thyroid Glandmentioning

confidence: 99%

“…Interestingly, the increased expression of GPX1 and SOD2 and augmented GPX and SOD activities have been reported in thyroid cancer when compared with normal tissue [ 48 , 75 , 76 , 77 ]. The expression of PIM-1 is overexpressed in PTCs and positively correlated with NOX4, GPX1, and SOD2 expression [ 75 ]. Interestingly, PIM-1, GPX1, and SOD2 protein expression are positively regulated by NOX4 in vitro, suggesting that NOX4 induces compensatory antioxidant responses through PIM-1 [ 75 ].…”

Section: Redox Homeostasis In the Thyroid Glandmentioning

confidence: 99%

“…The expression of PIM-1 is overexpressed in PTCs and positively correlated with NOX4, GPX1, and SOD2 expression [ 75 ]. Interestingly, PIM-1, GPX1, and SOD2 protein expression are positively regulated by NOX4 in vitro, suggesting that NOX4 induces compensatory antioxidant responses through PIM-1 [ 75 ]. It is tempting to speculate that these compensatory antioxidant responses might be essential to maintain elevated ROS in concentration ranges compatible with thyroid cancer cell survival.…”

Section: Redox Homeostasis In the Thyroid Glandmentioning

confidence: 99%

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Redox Homeostasis in Thyroid Cancer: Implications in Na+/I− Symporter (NIS) Regulation

Cazarin

Dupuy

Carvalho

2022

IJMS

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Radioiodine therapy (RAI) is a standard and effective therapeutic approach for differentiated thyroid cancers (DTCs) based on the unique capacity for iodide uptake and accumulation of the thyroid gland through the Na+/I− symporter (NIS). However, around 5–15% of DTC patients may become refractory to radioiodine, which is associated with a worse prognosis. The loss of RAI avidity due to thyroid cancers is attributed to cell dedifferentiation, resulting in NIS repression by transcriptional and post-transcriptional mechanisms. Targeting the signaling pathways potentially involved in this process to induce de novo iodide uptake in refractory tumors is the rationale of “redifferentiation strategies”. Oxidative stress (OS) results from the imbalance between ROS production and depuration that favors a pro-oxidative environment, resulting from increased ROS production, decreased antioxidant defenses, or both. NIS expression and function are regulated by the cellular redox state in cancer and non-cancer contexts. In addition, OS has been implicated in thyroid tumorigenesis and thyroid cancer cell dedifferentiation. Here, we review the main aspects of redox homeostasis in thyrocytes and discuss potential ROS-dependent mechanisms involved in NIS repression in thyroid cancer.

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PIM1 attenuates cisplatin-induced AKI by inhibiting Drp1 activation

Li,

Shi,

Zhao

et al. 2024

Cellular Signalling

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Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress

Cited by 9 publications

References 27 publications

Identification of prognostic biomarkers for papillary thyroid carcinoma by a weighted gene co‐expression network analysis

Identification of prognostic biomarkers for papillary thyroid carcinoma by a weighted gene co‐expression network analysis

Redox Homeostasis in Thyroid Cancer: Implications in Na+/I− Symporter (NIS) Regulation

PIM1 attenuates cisplatin-induced AKI by inhibiting Drp1 activation

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