Role of offending out-door aero-allergen and CD14 C(-159)T polymorphism in development and severity of asthma in a Kolkata patient population

Dutta, Shampa; Mondal, Priti; Saha, Nimai Chandra; Moitra, Saibal; Podder, Sanjoy; Ghosh, Amlan; Saha, Goutam Kumar

doi:10.4314/ahs.v17i4.18

Cited by 10 publications

(6 citation statements)

References 18 publications

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“…Although skin test results from eastern India are published in part for some dominant aeroallergens [6, 12], we present here for the first time a comprehensive summary of SPT results of common aeroallergens derived from the Allergy and Asthma Research Center, West Bengal, of eastern India. The aim of the present study is to evaluate the sensitivity of an atopic population toward common aeroallergens like airborne pollens, molds and house dust mites.…”

Section: Introductionmentioning

confidence: 99%

Sensitization to Common Aeroallergens in the Atopic Population of West Bengal, India: An Investigation by Skin Prick Test

Dey

Mondal

Laha

et al. 2018

Int Arch Allergy Immunol

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Background: Aeroallergen sensitization is increasing worldwide. The optimal management of allergic disease requires the identification of the allergic sensitivities of the patient. Complete data of offending aeroallergens are scant from West Bengal, India. Hence, we employed a retrospective analysis of an atopic population of West Bengal to investigate the rate of sensitivity toward common aeroallergens including pollens, molds and house dust mites. Objectives: The aim of the present study was to evaluate the profile of skin prick test (SPT) reactivity of an atopic population of eastern India. Methods: The prevalence aeroallergen sensitization was investigated by SPT along with a questionnaire survey of patients who visited the Allergy and Asthma Research Center of West Bengal, India, from June 2016 to May 2018. Patients were categorized according to the demographic (age, gender) and clinical aspects. Statistical tests were applied to differentiate between age and gender of the sufferers. Results: 524 out of 605 patients exhibited a positive SPT response toward one or more aeroallergens tested. One-way ANOVA following Tukey’s post hoc test reveals the age group of 15–40 years was more sensitized than that of < 15 years and no male-female discrimination was found using the paired t test. House dust mites, namely Dermatophagoides pteronyssinus and Dermatophagoides farinae, elicited most significant SPT results (80.34 and 84.92%, respectively) followed by Cocos (73.28%) and Azaridacta (57.25%) pollen. The most sensitive mold was Alternaria alternata (26.9%). Allergic rhinitis, bronchial asthma and atopic dermatitis were recorded as the common symptoms. Other influencing factors were family history, nature and season/time of onset and house conditions. Conclusion: Following the increasing trend, house dust mite sensitization still held the dominance like in any other Indian population reported earlier. This study would pave the way to construct a standard and minimal SPT panel for the atopic patients of eastern India.

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Section: Introductionmentioning

confidence: 99%

Sensitization to Common Aeroallergens in the Atopic Population of West Bengal, India: An Investigation by Skin Prick Test

Dey

Mondal

Laha

et al. 2018

Int Arch Allergy Immunol

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“…The associations of SNPs with allergic disease severity vary across studies. 33 , 45 VAS is a tool to evaluate AR severity using subjective indexes which may depend on individual cognition and sensitivity. Therefore, the correlation with disease severity cannot be fully explained from the perspective of SNPs alone, since the severity of AR is related to many other factors, such as quality of life, sleep status, daily activities, workload, course of disease, and so on.…”

Section: Discussionmentioning

confidence: 99%

TLR Signaling Pathway Gene Polymorphisms, Gene–Gene and Gene–Environment Interactions in Allergic Rhinitis

Chen¹,

Dai²,

Zhang³

et al. 2022

JIR

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Background Allergic rhinitis (AR) is a nasal inflammatory disease resulting from a complex interplay between genetic and environmental factors. The association between Toll-like receptor (TLR) signaling pathway and environmental factors in AR pathogenesis remains to be explored. This study aims to assess the genetic association of AR with single nucleotide polymorphisms (SNPs) in TLR signaling pathway, and investigate the roles of gene–gene and gene–environment interactions in AR. Methods A total of 452 AR patients and 495 healthy controls from eastern China were enrolled in this hospital-based case–control study. We evaluated putatively functional genetic polymorphisms in TLR2, TLR4 and CD14 genes for their association with susceptibility to AR and related clinical phenotypes. Interactions between environmental factors (such as traffic pollution, residence, pet keeping) and polymorphisms with AR were examined using logistic regression. Models were stratified by genotype and interaction terms, and tested for the significance of gene–gene and gene–environment interactions. Results In the single-locus analysis, two SNPs in CD14 , rs2563298 (A/C) and rs2569191 (C/T) were associated with a significantly decreased risk of AR. Compared with the GG genotype, the GT and GT/TT genotypes of TLR2 rs7656411 (G/T) were associated with a significantly increased risk of AR. Gene–gene interactions (eg, TLR2 rs7656411, TLR4 rs1927914, and CD14 rs2563298) was associated with AR. Gene–environment interactions (eg, TLR4 or CD14 polymorphisms and certain environmental exposures) were found in AR cases, but they were not significant after Bonferroni correction. Conclusion The genetic polymorphisms of TLR2 and CD14 and gene–gene interactions in TLR signaling pathway were associated with susceptibility to AR in this Han Chinese population. However, the present results were limited to support the association between gene–environment interactions and AR.

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“…513 Various factors influence the allergic sensitization to HDMs, such as ethnicity, socio-economic conditions, geographical variations etc. 514 HDMs include Dermatophagoiodes pteronyssinus (Dp) and Dermatophagoiodes farina (Df). Storage mites include Lepidoglyphus destructor (Ld), Blomia tropicalis (Bt), Tyrophagus putrescentiae (TP).…”

Section: Q4 What Are the Source/location Risk Factors And Clinical Si...mentioning

confidence: 99%

Indian Guidelines for Diagnosis of Respiratory Allergy

Prasad¹,

Prakash²,

Kumar³

et al. 2022

The Indian Journal of Chest Diseases and Allied Sciences

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Role of offending out-door aero-allergen and CD14 C(-159)T polymorphism in development and severity of asthma in a Kolkata patient population

Cited by 10 publications

References 18 publications

Sensitization to Common Aeroallergens in the Atopic Population of West Bengal, India: An Investigation by Skin Prick Test

Sensitization to Common Aeroallergens in the Atopic Population of West Bengal, India: An Investigation by Skin Prick Test

TLR Signaling Pathway Gene Polymorphisms, Gene–Gene and Gene–Environment Interactions in Allergic Rhinitis

Indian Guidelines for Diagnosis of Respiratory Allergy

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