Role of octreotide and prednisolone in prophylactic of poshepatectomy liver failure. Experimental study

Rb, Alikhanov; Av, Sorokina; Fg, Zabozlaev; Dn, Panchenkov; Da, Astakhov

doi:10.17116/hirurgia2016266-68

Khir. Z. im. N.I. Pirogova

2016

DOI: 10.17116/hirurgia2016266-68

|View full text |Cite

Role of octreotide and prednisolone in prophylactic of poshepatectomy liver failure. Experimental study

Alikhanov Rb

Sorokina Av

Zabozlaev Fg

et al.

Abstract: Octreotide infusion before the major hepatic resection may have protective effect on hepatocytes and accelerate the regeneration in the remnant liver.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Pathobiochemical Features of Posthepatectomy Liver Failure and Prospects for Its Metabolic Correction

Bykov,

Shevchenko,

Tsymbalyuk

et al. 2024

Innovacionnaâ medicina Kubani

View full text Add to dashboard Cite

We review the current understanding of pathophysiology and pathobiochemistry of conditions following extensive resections of the liver parenchyma and describe potential ways of surgical and metabolic correction, including promising molecular targets for therapy. Reduced residual tissue volume (small-for-size syndrome), parenchymal edema due to hyperperfusion and impaired venous blood outflow, septic complications, organ ischemia-reperfusion, mitochondrial dysfunction, and oxidative stress are considered key pathogenetic factors in liver failure development following extensive resections of the liver parenchyma. Given the above, promising ways of managing posthepatectomy conditions are the use of agents reducing portal pressure (octreotide [somatostatin analogue], terlipressin [vasopressin analogue], and propranolol), energotropic metabolic drugs (combined preparations of succinate and antioxidants, gasotransmitter donors), and antibiotics and synbiotics for prevention of infectious complications. The approaches currently used in clinical practice cannot always effectively manage complications following extensive hepatectomy, so fundamental research should focus on searching and creating effective strategies for prevention and therapy of posthepatectomy liver failure.

show abstract

Pathobiochemical Features of Posthepatectomy Liver Failure and Prospects for Its Metabolic Correction

Bykov,

Shevchenko,

Tsymbalyuk

et al. 2024

Innovacionnaâ medicina Kubani

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Role of octreotide and prednisolone in prophylactic of poshepatectomy liver failure. Experimental study

Abstract: Octreotide infusion before the major hepatic resection may have protective effect on hepatocytes and accelerate the regeneration in the remnant liver.

Cited by 1 publication

References 6 publications

Pathobiochemical Features of Posthepatectomy Liver Failure and Prospects for Its Metabolic Correction

Pathobiochemical Features of Posthepatectomy Liver Failure and Prospects for Its Metabolic Correction

Contact Info

Product

Resources

About